Immunostimulatory activities of yam tuber mucilages

Botanical Studies

Volumn 48, Issue 1, 2007, Pages 63-70

  Shang, Huey Fang ^a   Cheng, Huey Chuan ^b,c   Liang, Hong Jen ^d   Liu, Hao Yu ^a   Liu, Sin Yie ^e   Hou, Wen Chi ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^d Department of Food Science   (Taiwan)

^e FISHERIES RESEARCH INSTITUTE   (Taiwan)

Author keywords

Dioscorea; Immunostimulatory; Lentinan; Mucilage; Nk cell; Phagocytic activity; Yam

Indexed keywords

DIOSCOREA; DIOSCOREA ALATA; MURINAE; MUS;

EID: 33847144885     PISSN: 1817406X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Akoruda, M.O. 1984. Genetic improvement of vegetable crops: yam (Dioscorea spp.). In M. Kasloo (ed.), Genetic Improvement of Vegetable Crops. Pergamon Press, pp. 717-733.
2. Bailey, C.J. and C. Day. 1989. Traitional plant medicines as treatments for diabetes. Diabetes Care 12: 553-564.
3. Brown, G.D. and S. Gordon. 2003. Fungal β-glucans and mammalian immunity. Immunity 19: 311-315.
4. Butcher, S.K., H. Chahal, L. Nayak, A. Sinclair, N.V. Henriquez, E. Sapey, D. O'Mahony, and J.M. Lord. 2001. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly human. J. Leuk. Biol. 70: 881-886.
5. Chang, Y.W. and T.J. Lu. 2004. Molecular characterization of polysaccharides in hot-water extracts of Ganoderma lucidum fruiting bodies. J. Food Drug Anal. 12: 59-67.
6. Chang, S.J., Y.C. Lee, S.Y. Liu, and T.W. Chang. 2004. Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidant effects in hyperhomocysteinemia rats. J. Agric. Food Chem. 52: 1720-1725.
7. Choi, E.M. and J.K. Hwang. 2002. Enhancement of oxidative response and cytokine production by yam mucopolysaccharide in murine peritoneal macrophage. Fitoterapia 73: 629-637.
8. Choi, E.M., S.J. Koo, and J.K. Hwang. 2004. Immune cell stimulating activity of mucopolysaccharide isolated from yam (Dioscorea batatas). J. Ethnopharmacol. 91: 1-6.
9. Council of Agriculture, Executive Yuan. 2004. A guidebook for the care and use of laboratory Animals, Council of Agriculture, Executive Yuan, Taipei, Taiwan, Republic of China.
10. Diefenbach, A. and D.H. Raulet. 2001. Strategies for target cell recognition by natural killer cells. Immunol. Rev. 181: 170-184.
11. Feizi, T. 2000. Carbohydrate-mediated recognition systems in innate immunity. Immuno. Rev. 173: 79-88.
12. Gaforio, J.J., M.J. Serrano, E. Ortega, L. Algarra, and G.A. de Cienfuegos. 2002. Use of SYTOX green dye in the flow cytometric analysis of bacterial phagocytosis. Cytometry 48: 93-96.
13. Hikino, H., C. Konno, M. Takahashi, M. Murakami, Y. Kato, M. Karikura, and T. Hayashi. 1986. Isolation and hypoglycemic activity of dioscoran A, B, C, D, E, and F; glycans of Dioscorea japonica rhizophors. Planta Med. 52: 168-171.
14. Hoshi, H., Y. Yagi, H. Iijima, K. Matsunaga, Y. Ishihara, and T. Yasuhara. 2005. Isolation and characterization of a novel immunomodulatory α-glucan-protein complex from the mycelium of Tricholoma matsutake in Basidiomycetes. J. Agric. Food Chem. 53: 8948-8956.
15. Hou, W.C., F.L. Hsu, and M.H. Lee. 2002. Yam (Dioscorea batatas Decne) tuber mucilage exhibited antioxidant activities in vitro. Planta Med. 68: 1072-1076.
16. Hsu, S.Y., K. F. Hua, C.C. Lin, C.H. Lin, J. Hsu, and C.H. Wong. 2004. Extract of Reishi polysaccharides induces cytokine expression via TRL4-modulated protein kinase signaling pathways. J. Immunol. 173: 5989-599.
17. Lee, M.H., Y. S. Lin, Y. H. Lin, F.L. Hsu, and W.C. Hou. 2003. The mucilage of yam (Dioscorea batatas Decne) tuber exhibited angiotensin converting enzyme inhibitory activities. Bot. Bull. Acad. Sin. 44: 267-273.
18. Lin, S.Y., H.Y. Liu, Y.L. Lu, and W.C. Hou. 2005. Antioxidant activities of mucilages from different Taiwanese yam cultivars. Bot. Bull. Acad. Sin. 46: 183-188.
19. Liu, S.Y., J.Y. Wang, Y.T. Shyu, and L.M. Song. 1995. Studies on yam (Dioscorea spp.) in Taiwan. J. Chin. Med. 6: 111-126.
20. Misaki, A., T. Ito, and T. Harada. 1972. Constitutional studies on the mucilage of yamanoimo, Dioscorea batatas Decne, forma Tsukune. Isolation and structure of a mannan. Agri. Biol. Chem. 36: 761-771.
21. Mlčková, P., D. Čechová, P. Chalupná, O. Novotná, and L. Prokešová. 2001. Ehanced systemic and mucosal antibody responses to a model protein antigen after intranasal and intratracheal immunization using Bacillus firmus as an adjuvant. Immunol. Lett. 77: 39-45.
22. Mosmann, T.R. and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17: 138-146.
23. Okamoto, I., Y. Taniguchi, T. Kunikata, K. Kohno, K. Iwaki, M. Ikeda, and M. Kurimoto. 2003. Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sci. 73: 2029-2045.
24. Ou, H.T., C.J. Shieh, J.Y.J. Chen, and H.M. Chang. 2005. The antiproliferative and differentiating effects of human leukemic U937 cells are mediated by cytokines from activated mononuclear cells by dietary mushrooms. J. Agric. Food Chem. 53: 300-305.
25. Pugh, N., S.A. Ross, H.N. ElSohly, M.A. ElSohly, and D.S. Pasco. 2001. Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, Aphanizomenon flos-aquae, and Chlorella pyrenoidosa. Plant Medica 67: 737-742.
26. Sinclair, N.D. 1998. Chinese herbs: a clinical review of Astragalus, Ligusticum, and Schizandrae. Altern. Med. Rev. 3: 338-344.
27. Son, E.H., E.Y. Moon, D.K. Rhee, and S. Pyo. 2001. Stimulation of various functions in murine peritoneal macrophages by high mannuronic acid-containiong alginate (HMA) exposure in vivo. Internat. Immunopharmacol. 1: 147-154.
28. Sosroseno, W., P.S. Bird, and G.J. Seymour. 2003. Intracellular proteins involved in Porphyromonas gingivalis-induced opsonophagocytic activities of a murine macrophage cell line (RAW264.7 cells). J. Microbiol. Immunol. Infect. 36: 229-235.
29. Stuart, L.M. and R.A.B. Ezekowitz. 2005. Phagocytosis: Elegant complexity. Immunity 22: 539-550.
30. Tsai, S.S. and F.J. Tai. 1984. Studies on the mucilage from tuber of yam (Dioscorea alata Linn.) I. Isolation and purification of the mucilage. J. Chin. Agri. Chem. Soc. 22: 88-94.
31. Van den Berg, T.K., E.A. Döpp, and C.D. Dijkstra. 2001. Rat macrophages: membrane glycoproteins in differentiation and function. Immunol. Rev. 184: 45-57.
32. Vetvicka, V. and J.C. Yvin. 2004. Effects of marine β-1,3 glucan on immune reactions. Internat. Immunopharmacol. 4: 721-730.
33. Viau, M., N.S. Longo, P.E. Lipsky, and M. Zouali. 2005. Staphylococcal protein A deletes B-1a and marginal zone B lymphocytes expressing human immunoglobulins: an immune evasion mechanism. J. Immunol. 175: 7719-7727.
34. Wasser, S.P. 2002. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl. Microbiol. Biotechnol. 60: 258-274.
35. Yeh, S.L., Y.N. Lai, F.F. Shang, M.T. Lin, and W.J. Chen. 2004. Effects of glutamine supplementation on innate immune response in rats with gut-derived sepsis. Brit. J. Nutri. 91: 423-429.
36. Zhang, L., X. Li, X. Xu, and F. Zeng. 2005. Correlation between antitumor activity, molecular weight, and conformation of lentinan. Carbohydr. Res. 340: 1515-1521.
37. Zhu, X.L. and Z.B. Lin. 2005. Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells. Acta Pharmacol. Sin. 26: 1130-1137.