The influence of neuropathology on the fMRI Signal: A measurement of brain or vein?

Clinical Neuropsychologist

Volumn 21, Issue 1, 2007, Pages 58-72

  Hillary, F G ^a   Biswal, B ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Blood flow; CBF; fMRI; Functional imaging; Lesions; TBI

Indexed keywords

AGING; BEHAVIOR DISORDER; BIOPHYSICAL EQUIPMENT; BLOOD FLOW; BRAIN CIRCULATION; BRAIN DAMAGE; BRAIN DISEASE; BREATH HOLDING; CLINICAL EXAMINATION; CORRELATION ANALYSIS; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMICS; HUMAN; MEASUREMENT; NEUROIMAGING; NEUROLOGIC EXAMINATION; NEUROPATHOLOGY; NONHUMAN; PHYSIOLOGY; REVIEW; TRAUMATIC BRAIN INJURY;

ADOLESCENT; ADULT; BLOOD FLOW VELOCITY; BRAIN; BRAIN INJURIES; BRAIN INJURY, CHRONIC; CEREBRAL VEINS; DOMINANCE, CEREBRAL; FEMALE; GLASGOW COMA SCALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PILOT PROJECTS; REFERENCE VALUES; REGIONAL BLOOD FLOW;

EID: 33847107942     PISSN: 13854046     EISSN: 17444144     Source Type: Journal    
DOI: 10.1080/13854040601064542     Document Type: Review

References (65)

1. An, H., Lin, W., Celik, A., & Lee, Y. Z. (2001). Quantitative measurements of cerebral metabolic rate of oxygen utilization using MRI: A volunteer study. NMR in Biomedicine, 14(7-8), 441-447.
2. Au Duong, M. V., Boulanouar, K., Audoin, B., Treseras, S., Ibarrola, D., Malikova, I. et al. (2005). Modulation of effective connectivity inside the working memory network in patients at the earliest stage of multiple sclerosis. Neuroimage, 24(2), 533-538.
3. Audoin, B., Ibarrola, D., Ranjeva, J. P., Confort-Gouny, S., Malikova, I., Ali-Cherif, A. et al. (2003). Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of ms. Human Brain Mapping, 20(2), 51-58.
4. Audoin, B., Van Au Duong, M., Ranjeva, J. P., Ibarrola, D., Malikova, I., Confort-Gouny, S. et al. (2005). Magnetic resonance study of the influence of tissue damage and cortical reorganization on PASAT performance at the earliest stage of multiple sclerosis. Human Brain Mapping, 24(3), 216-228.
5. Barbier, E. L., Lamalle, L., & Decorps, M. (2001). Methodology of brain perfusion imaging. Journal of Magnetic Resonance Imaging, 13(4), 496-520.
6. Biagas, K. V., Grundl, P. D., Kochanek, P. M., Schiding, J. K., & Nemoto, E. M. (1996). Posttraumatic hyperemia in immature, mature, and aged rats: Autoradiographic determination of cerebral blood flow. Journal of Neurotrauma, 13(4), 189-200.
7. Biswal, B., DeYoe, A. E., & Hyde, J. S. (1996). Reduction of physiological fluctuations in fMRI using digital filters. Magnetic Resonance in Medicine, 35(1), 107-113.
8. Biswal, B. B. & Hyde, J. S. (1997). Contour-based registration technique to differentiate between task-activated and head motion-induced signal variations in fMRI. Magnetic Resonance in Medicine, 38(3), 470-476.
9. Biswal, B. B., Pathak, A. P., Ulmer, J. L., & Hudetz, A. G. (2003). Decoupling of the hemodynamic and activation-induced delays in functional magnetic resonance imaging. Journal of Computer Assisted Tomography, 27(2), 219-225.
10. Bouma, G. J., Muizelaar, J. P., Choi, S. C., Newlon, P. G., & Young, H. F. (1991). Cerebral circulation and metabolism after severe traumatic brain injury: The elusive role of ischemia. Journal of Neurosurgery, 75(5), 685-693.
11. Chang, L., Ernst, T., Leonido-Yee, M., & Speck, O. (2000). Perfusion mri detects rCBF abnormalities in early stages of HIV-cognitive motor complex. Neurology, 54(2), 389-396.
12. Chang, L., Speck, O., Miller, E. N., Braun, J., Jovicich, J., Koch, C. et al. (2001). Neural correlates of attention and working memory deficits in HIV patients. Neurology, 57(6), 1001-1007.
13. Chen, J. K., Johnston, K. M., Frey, S., Petrides, M., Worsley, K., & Ptito, A. (2004). Functional abnormalities in symptomatic concussed athletes: An fMRI study. Neuroimage, 22(1), 68-82.
14. Christodoulou, C., DeLuca, J., Ricker, J. H., Madigan, N. K., Bly, B. M., Lange, G. et al. (2001). Functional magnetic resonance imaging of working memory impairment after traumatic brain injury. Journal of Neurology, Neurosurgery and Psychiatry, 71(2), 161-168.
15. D'Esposito, M., Deouell, L. Y., & Gazzaley, A. (2003). Alterations in the bold fMRI signal with ageing and disease: A challenge for neuroimaging. Nature Reviews Neuroscience, 4(11), 863-872.
16. D'Esposito, M., Zarahn, E., Aguirre, G. K., & Rypma, B. (1999). The effect of normal aging on the coupling of neural activity to the bold hemodynamic response. Neuroimage, 10(1), 6-14.
17. Desmond, J. E. & Annabel Chen, S. H. (2002). Ethical issues in the clinical application of fMRI: Factors affecting the validity and interpretation of activations. Brain and Cognition, 50(3), 482-497.
18. Ernst, T., Chang, L., & Arnold, S. (2003). Increased glial metabolites predict increased working memory network activation in HIV brain injury. Neuroimage, 19(4), 1686-1693.
19. Ernst, T., Chang, L., Jovicich, J., Ames, N., & Arnold, S. (2002). Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients. Neurology, 59(9), 1343-1349.
20. 2 reactivity after controlled cortical impact by perfusion magnetic resonance imaging using arterial spinlabeling in rats. Journal of Cerebral Blood Flow and Metabolism, 17(8), 865-874.
21. Golding, E. M. (2002). Sequelae following traumatic brain injury. The cerebrovascular perspective. Brain Research and Brain Research Review, 38(3), 377-388.
22. Grossman, M., Koenig, P., DeVita, C., Glosser, G., Moore, P., Gee, J. et al. (2003a). Neural basis for verb processing in Alzheimer's disease: An fMRI study. Neuropsychology, 17(4), 658-674.
23. Grossman, M., Koenig, P., Glosser, G., DeVita, C., Moore, P., Rhee, J. et al. (2003b). Neural basis for semantic memory difficulty in Alzheimer's disease: An fMRI study. Brain, 126(Pt 2), 292-311.
24. Harrison-Felix, C., Newton, N., Hall, K. M., & Kreutzer, J. S. (1996). Descriptive findings from the traumatic brain injury model systems national database. Journal of Head Trauma Rehabilitation, 11(5), 1-14.
25. Hattori, N., Huang, S. C., Wu, H. M., Liao, W., Glenn, T. C., Vespa, P. M. et al. (2003). Pet investigation of post-traumatic cerebral blood volume and blood flow. Acta Neurochirurgica Supplement, 86, 49-52.
26. Hattori, N., Huang, S. C., Wu, H. M., Liao, W., Glenn, T. C., Vespa, P. M. et al. (2004). Acute changes in regional cerebral (18)f-FDG kinetics in patients with traumatic brain injury. Journal of Nuclear Medicine, 45(5), 775-783.
27. Hennig, J., Speck, O., Koch, M. A., & Weiller, C. (2003). Functional magnetic resonance imaging: A review of methodological aspects and clinical applications. Journal of Magnetic Resonance Imaging, 18(1), 1-15.
28. Hillary, F. G., Chiaravalloti, N. D., Ricker, J. H., Steffener, J., Bly, B. M., Lange, G. et al. (2003). An investigation of working memory rehearsal in multiple sclerosis using fMRI. Journal of Clinical and Experimental Neuropsychology, 25(7), 965-978.
29. Kamper, A. M., Spilt, A., de Craen, A. J., van Buchem, M. A., Westendorp, R. G., & Blauw, G. J. (2004). Basal cerebral blood flow is dependent on the nitric oxide pathway in elderly but not in young healthy men. Experimental Gerontology, 39(8), 1245-1248.
30. Kannurpatti, S. S., Biswal, B. B., & Hudetz, A. G., (2003). Regional dynamics of the fMRI-BOLD signal response to hypoxia-hypercapnia in the rat brain. Journal of Magnetic Resonance Imaging, 17(6), 641-647.
31. Kastrup, A., Kruger, G., Neumann-Haefelin, T., & Moseley, M. E. (2001). Assessment of cerebrovascular reactivity with functional magnetic resonance imaging: Comparison of co(2) and breath holding. Magnetic Resonance Imaging, 19(1), 13-20.
32. Kastrup, A., Li, T. Q., Glover, G. H., & Moseley, M. E. (1999). Cerebral blood flow-related signal changes during breath-holding. AJNR American Journal of Neuroradiology, 20(7), 1233-1238.
33. Kastrup, A., Li, T. Q., Takahashi, A., Glover, G. H., & Moseley, M. E. (1998). Functional magnetic resonance imaging of regional cerebral blood oxygenation changes during breath holding. Stroke, 29(12), 2641-2645.
34. Kochanek, P. M., Hendrich, K. S., Dixon, C. E., Schiding, J. K., Williams, D. S., & Ho, C. (2002). Cerebral blood flow at one year after controlled cortical impact in rats: Assessment by magnetic resonance imaging. Journal of Neurotrauma, 19(9), 1029-1037.
35. Kochanek, P. M., Marion, D. W., Zhang, W., Schiding, J. K., White, M., Palmer, A. M. et al. (1995). Severe controlled cortical impact in rats: Assessment of cerebral edema, blood flow, and contusion volume. Journal of Neurotrauma, 12(6), 1015-1025.
36. Law, M., Saindane, A. M., Ge, Y., Babb, J. S., Johnson, G., Mannon, L. J. et al. (2004). Microvascular abnormality in relapsing-remitting multiple sclerosis: Perfusion MR imaging findings in normal-appearing white matter. Radiology, 231(3), 645-652.
37. Levin, H. S. (1995). Prediction of recovery from traumatic brain injury. Journal of Neurotrauma, 12(5), 913-922.
38. Li, T. Q., Kastrup, A., Takahashi, A. M., & Moseley, M. E. (1999). Functional MRI of human brain during breath holding by BOLD and FAIR techniques. Neuroimage, 9(2), 243-249.
39. Mainero, C., Caramia, F., Pozzilli, C., Pisani, A., Pestalozza, I., Borriello, G. et al. (2004). fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosis. Neuroimage, 21(3), 858-867.
40. Maini, C. L., Pigorini, F., Pau, F. M., Volpini, V., Galgani, S., Rosci, M. A. et al. (1990). Cortical cerebral blood flow in HIV-1-related dementia complex. Nuclear Medicine Communications, 11(9), 639-648.
41. Mandeville, J. B., Marota, J. J., Kosofsky, B. E., Keltner, J. R., Weissleder, R., Rosen, B. R. et al. (1998). Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magnetic Resonance in Medicine, 39(4), 615-624.
42. Mandzia, J., Black, S., Grady, C., McAndrews, M. P., & Graham, S. (2002). Encoding and retrieval in aging and memory loss, a fMRI study. Brain and Cognition, 49(2), 225-228.
43. Manoach, D. S., Gollub, R. L., Benson, E. S., Searl, M. M., Goff, D. C., Halpern, E. et al. (2000). Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry, 48(2), 99-109.
44. Martin, N. A., Patwardhan, R. V., Alexander, M. J., Africk, C. Z., Lee, J. H., Shalmon, E. et al. (1997). Characterization of cerebral hemodynamic phases following severe head trauma: Hypoperfusion, hyperemia, and vasospasm. Journal of Neurosurgery, 87(1), 9-19.
45. McAllister, T. W., Saykin, A. J., Flashman, L. A., Sparling, M. B., Johnson, S. C., Guerin, S. J. et al. (1999). Brain activation during working memory 1 month after mild traumatic brain injury: A functional MRI study. Neurology, 53(6), 1300-1308.
46. McAllister, T. W., Sparling, M. B., Flashman, L. A., Guerin, S. J., Mamourian, A. C., & Saykin, A. J. (2001). Differential working memory load effects after mild traumatic brain injury. Neuroimage, 14(5), 1004-1012.
47. Meltzer, C. C., Cantwell, M. N., Greer, P. J., Ben-Eliezer, D., Smith, G., Frank, G. et al. (2000). Does cerebral blood flow decline in healthy aging? A pet study with partial-volume correction. Journal of Nuclear Medicine, 41(11), 1842-1848.
48. Perlstein, W. M., Carter, C. S., Noll, D. C., & Cohen, J. D. (2001). Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry, 158(7), 1105-1113.
49. Perlstein, W. M., Cole, M. A., Demery, J. A., Seignourel, P. J., Dixit, N. K., Larson, M. J. et al. (2004). Parametric manipulation of working memory load in traumatic brain injury: Behavioral and neural correlates. Journal of the International Neuropsychological Society, 10(5), 724-741.
50. Perlstein, W. M., Dixit, N. K., Carter, C. S., Noll, D. C., & Cohen, J. D. (2003). Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophrenia. Biological Psychiatry, 53(1), 25-38.
51. Prigatano, G. P., Johnson, S. C., & Gale, S. D. (2004). Neuroimaging correlates of the Halstead finger tapping test several years post-traumatic brain injury. Brain Injury, 18(7), 661-669.
52. Ricker, J. H., Hillary, F. G., & DeLuca, J. (2001). Functionally activated brain imaging (o-15 PET and fMRI) in the study of learning and memory after traumatic brain injury. Journal of Head Trauma Rehabilitation, 16(2), 191-205.
53. Rosenthal, M., & Ricker, J. H. (2000). Traumatic brain injury. In R. G. Frank & T. R. Elliot (Eds.), Handbook of rehabilitation psychology (pp. 56-57). Washington DC: American Psychological Association.
54. Schroder, M. L., Muizelaar, J. P., Kuta, A. J., & Choi, S. C. (1996). Thresholds for cerebral ischemia after severe head injury: Relationship with late CT findings and outcome. Journal of Neurotrauma, 13(1), 17-23.
55. Segatore, M., & Way, C. (1992). The Glasgow Coma Scale: Time for a change. Heart & Lung, 21, 548-557.
56. Sierra, C., de la Sierra, A., Chamorro, A., Larrousse, M., Domenech, M., & Coca, A. (2004). Cerebral hemodynamics and silent cerebral white matter lesions in middle-aged essential hypertensive patients. Blood Pressure, 13(5), 304-309.
57. Staffen, W., Mair, A., Zauner, H., Unterrainer, J., Niederhofer, H., Kutzelnigg, A. et al. (2002). Cognitive function and fMRI in patients with multiple sclerosis: Evidence for compensatory cortical activation during an attention task. Brain, 125(Pt 6), 1275-1282.
58. Sutton, R. L., Hovda, D. A., Adelson, P. D., Benzel, E. C., & Becker, D. P. (1994). Metabolic changes following cortical contusion: Relationships to edema and morphological changes. Acta Neurochirurgica Supplement (Wien), 60, 446-448.
59. Swank, R. L., Roth, J. G., & Woody, D. C. Jr. (1983). Cerebral blood flow and red cell delivery in normal subjects and in multiple sclerosis. Neurological Research, 5(1), 37-59.
60. Tran Dinh, Y. R., Mamo, H., Cervoni, J., Caulin, C., & Saimot, A. C. (1990). Disturbances in the cerebral perfusion of human immune deficiency virus-1 seropositive asymptomatic subjects: A quantitative tomography study of 18 cases. Journal of Nuclear Medicine, 31(10), 1601-1607.
61. Turner, R., Le Bihan, D., Moonen, C. T., Despres, D., & Frank, J. (1991). Echo-planar time course MRI of cat brain oxygenation changes. Magnetic Resonance in Medicine, 22(1), 159-166.
62. Wishart, H. A., Saykin, A. J., McDonald, B. C., Mamourian, A. C., Flashman, L. A., Schuschu, K. R. et al. (2004). Brain activation patterns associated with working memory in relapsing-remitting MS. Neurology, 62(2), 234-238.
63. Yamaki, T., Imahori, Y., Ohmori, Y., Yoshino, E., Hohri, T., Ebisu, T. et al. (1996a). Cerebral hemodynamics and metabolism of severe diffuse brain injury measured by pet. Journal of Nuclear Medicine, 37(7), 1166-1170.
64. Yamaki, T., Yoshino, E., Fujimoto, M., Ohmori, Y., Imahori, Y., & Ueda, S. (1996b). Chronological positron emission tomographic study of severe diffuse brain injury in the chronic stage. Journal of Trauma, 40(1), 50-56.
65. Zaharchuk, G., Mandeville, J. B., Bogdanov, A. A. Jr., Weissleder, R., Rosen, B. R., & Marota, J. J. (1999). Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension. Stroke, 30(10), 2197-2204; discussion, 2204-2195.