Folic Acid Prevents and Partially Reverses Glucocorticoid-Induced Hypertension in the Rat

American Journal of Hypertension

Volumn 20, Issue 3, 2007, Pages 304-310

  Miao, Yuchun ^a   Zhang, Yi ^a   Lim, Pek S ^a   Kanjanapan, Yada ^a   Mori, Trevor A ^b   Croft, Kevin D ^b   Earl, John ^c   Lee, Sze Y ^a   McKenzie, Katja U S ^a   Hu, Lexian ^a   Whitworth, Judith A ^a  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Blood pressure; folic acid; glucocorticoid; rat; tetrahydrobiopterin

Indexed keywords

ASCORBIC ACID; BIOPTERIN; CORTICOTROPIN; DEXAMETHASONE; FOLIC ACID; GLUCOCORTICOID; HOMOCYSTEINE; ISOPROSTANE DERIVATIVE; NITRIC OXIDE; TETRACOSACTIDE ZINC PHOSPHATE; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; FOLIC ACID BLOOD LEVEL; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RAT; SYSTOLIC BLOOD PRESSURE;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOPTERIN; BLOOD PRESSURE; BODY WEIGHT; DEXAMETHASONE; DISEASE MODELS, ANIMAL; F2-ISOPROSTANES; FOLIC ACID; GLUCOCORTICOIDS; HOMOCYSTEINE; HYPERTENSION; MALE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; THYMUS GLAND; TIME FACTORS;

EID: 33847104141     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2006.08.007     Document Type: Article

References (31)

1. Mangos G.J., Turner S.W., Fraser T.B., and Whitworth J.A. The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat. J Hypertens 18 (2000) 1849-1855
2. Wen C., Li M., Fraser T., Wang J., Turner S.W., and Whitworth J.A. L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. Blood Press 9 (2000) 298-304
3. Turner S.W., Wen C., Li M., and Whitworth J.A. L-arginine prevents corticotropin-induced increases in blood pressure in the rat. Hypertension 27 (1996) 184-189
4. Wen C., Li M., and Whitworth J.A. Role of nitric oxide in adrenocorticotrophin-induced hypertension: L-arginine effects reversed by N-nitro-L-arginine. Clin Exp Pharmacol Physiol 27 (2000) 887-890
5. Simmons W.W., Ungureanu-Longrois D., Smith G.K., Smith T.W., and Kelly R.A. Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and L-arginine transport. J Biol Chem 271 (1996) 23928-23937
6. Li M., Fraser T., Wang J., and Whitworth J.A. Dexamethasone-induced hypertension in the rat: effects of L-arginine. Clin Exp Pharmacol Physiol 24 (1997) 730-732
7. Hu L., Zhang Y., Lim P.S., Miao Y., Tan C., McKenzie K.U.S., Schyvens C.G., and Whitworth J.A. Apocynin but not L-arginine prevents and reverses dexamethasone-induced hypertension in the rat. Am J Hypertens 19 (2006) 413-418
8. Landmesser U., Dikalov S., Price S.R., McCann L., Fukai T., Holland S.M., Mitch W.E., and Harrison D.G. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111 (2003) 1201-1209
9. Zhang Y., Jang R., Mori T.A., Croft K.D., Schyvens C.G., McKenzie K.U.S., and Whitworth J.A. The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat. J Hypertens 21 (2003) 1613-1618
10. Zhang Y., Croft K.D., Mori T.A., Schyvens C.G., McKenzie K.U.S., and Whitworth J.A. The anti-oxidant Tempol prevents and partially reverses dexamethasone-induced hypertension in the rat. Am J Hypertens 17 (2004) 260-265
11. Zhang Y., Chan M.M.K., Andrews M.C., Mori T.A., Croft K.D., McKenzie K.U.S., Schyvens C.G., and Whitworth J.A. Apocynin but not allopurinol prevents and reverses ACTH-induced hypertension in the rat. Am J Hypertens 18 (2005) 910-916
12. Mondo C.K., Zhang Y., Possamai V., Miao Y., Schyvens C.G., McKenzie K.U.S., Hu L., Guo Z., and Whitworth J.A. N-Acetylcysteine partially prevents but does not reverse acth-induced hypertension in the rat. Clin Exp Hypertens 28 (2006) 73-84
13. Hong H.J., Hsiao G., Cheng T.H., and Yen M.H. Supplementation with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 38 (2001) 1044-1048
14. Zhang Y., Pang T., Earl J., Schyvens C.G., McKenzie K.U.S., and Whitworth J.A. Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat. Clin Exp Hypertens 26 (2004) 231-241
15. Das U.N. Folic acid says NO to vascular diseases. Nutrition 19 (2003) 686-692
16. Topal G., Brunet A., Millanvoye E., Boucher J.L., Rendu F., Devynck M.A., and David-Dufilho M. Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin. Free Radic Biol Med 36 (2004) 1532-1541
17. Terzolo M., Allasino B., Bosio S., Brusa E., Daffara F., Ventura M., Aroasio E., Sacchetto G., Reimondo G., Angeli A., and Camaschella C. Hyperhomocysteinemia in patients with Cushing's syndrome. J Clin Endocrinol Metab 89 (2004) 3745-3751
18. Fraser T.B., Turner S.W., Mangos G.J., Ludbrook J., and Whitworth J.A. Comparison of telemetric and tail-cuff blood pressure monitoring in adrenocorticotrophic hormone-treated rats. Clin Exp Pharmacol Physiol 28 (2001) 831-835
19. Moat S.J., Lang D., McDowell I.F., Clarke Z.L., Madhavan A.K., Lewis M.J., and Goodfellow J. Folate, homocysteine, endothelial function and cardiovascular disease. J Nutr Biochem 15 (2004) 64-79
20. Rodrigo R., Passalacqua W., Araya J., Orellana M., and Rivera G. Homocysteine and essential hypertension. J Clin Pharmacol 43 (2003) 1299-1306
21. Mangoni A.A., Sherwood R.A., Swift C.G., and Jackson S.H. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Intern Med 252 (2002) 497-503
22. Whitworth J.A., Williamson P.M., Mangos G., and Kelly J.J. Cardiovascular consequences of cortisol excess. Vascular Health and Risk Management 1 (2005) 291-299
23. Wallerath T., Godecke A., Molojavyi A., Li H., Schrader J., and Forstermann U. Dexamethasone lacks effect on blood pressure in mice with a disrupted endothelial NO synthase gene. Nitric Oxide 10 (2004) 36-41
24. Lou Y.K., Wen C., Li M., Adams D.J., Wang M.X., Yang F., Morris B.J., and Whitworth J.A. Decreased renal expression of nitric oxide synthase isoforms in adrenocorticotropin-induced and corticosterone-induced hypertension. Hypertension 37 (2001) 1164-1170
25. Li M., Dusting G.J., and Whitworth J.A. Inhibition of NO synthesis has an additive effect on hypertension induced by ACTH in conscious rats. Clin Exp Pharmacol Physiol 19 (1992) 675-681
26. Vasquez-Vivar J., Martasek P., Whitsett J., Joseph J., and Kalyanaraman B. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. Biochem J 362 (2002) 733-739
27. Joshi R., Adhikari S., Patro B.S., Chattopadhyay S., and Mukherjee T. Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radic Biol Med 30 (2001) 1390-1399
28. Verhaar M.C., Wever R.M., Kastelein J.J., van Dam T., Koomans H.A., and Rabelink T.J. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97 (1998) 237-241
29. Doshi S.N., McDowell I.F., Moat S.J., Lang D., Newcombe R.G., Kredan M.B., Lewis M.J., and Goodfellow J. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arterioscler Thromb Vasc Biol 21 (2001) 1196-1202
30. Diez N., Perez R., Hurtado V., and Santidrian S. Hyperhomocysteinaemia induced by dietary folate restriction causes kidney oxidative stress in rats. Br J Nutr 94 (2005) 204-210
31. Stiefel P., Arguelles S., Garcia S., Jimenez L., Aparicio R., Carneado J., Machado A., and Ayala A. Effects of short-term supplementation with folic acid on different oxidative stress parameters in patients with hypertension. Biochim Biophys Acta 1726 (2005) 152-159