Adaptive response and human benefit: Part I. A microdosimetry dose-dependent model

International Journal of Radiation Biology

Volumn 83, Issue 2, 2007, Pages 115-131

  Leonard, Bobby E ^a  

^a International Academy   (United States)

Author keywords

Adaptive response; Microdosimetry model; Radioprotection

Indexed keywords

RADON;

ADAPTATION; ARTICLE; BIOPHYSICS; CELL NUCLEUS; CHROMOSOME ABERRATION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; LINEAR ENERGY TRANSFER; LYMPHOCYTE; MATHEMATICAL MODEL; MICRODOSIMETRY; MOLECULAR MECHANICS; POISSON DISTRIBUTION; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION INJURY;

ADAPTATION, PHYSIOLOGICAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MODELS, BIOLOGICAL; NANOTECHNOLOGY; POISSON DISTRIBUTION; RADIATION TOLERANCE; RADIOMETRY;

EID: 33847095911     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000601123047     Document Type: Article

References (50)

1. Attix FH. 1986. Introduction to radiological physics and radiation dosimetry. New York: John Wiley and Sons.
2. Azzam SM, Detoledo GP, Raaphorst GP, Mitchell RE. 1996. Low-dose ionizing radiation decreases the frequency of neoplastic transformation to a low level below the spontaneous rate in C3H 10T1/2 cells. Radiation Research 146:369-373.
3. Beir VI, National Research Council. 1998. Committee on the biological effects of ionizing radiation. Health effects of exposure to radon. Washington, DC: National Academy Press.
4. 3H thymidine: dosimetric, radiobiological and radiation protection aspects. Health Physics 12:1007-1020.
5. Bond VP, Varma MN, Sondhaus CA, Feinendegen LE. 1985. An alternative to absorbed dose, quality and RBE at low exposures. Radiation Research 104:S52-57.
6. Brenner DJ, Elliston CD. 2001. The potential impact of bystander effects on radiation risks in aMars mission. Radiation Research 156:612-617.
7. Brenner DJ, et al. 2001. The bystander effect in radiation oncogenesis. II. A quantitative model. Radiation Research 155:102-108.
8. Brooks AL, Newton GJ, Shyr LJ, Seiler FA, Scott BR. 1990. The combined effects of α-particle and x-rays on cell killing and micronuclei induction in lung epithelial cells. International Journal of Radiation Biology 58:799-811.
9. 60Co γ-rays for induction of micronuclei in vitro and in vivo. International Journal of Radiation Biology 66:801-808.
10. Chilakamarti VR, Boldogh I, Izumi T, Mitra S. 1998. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proceedings of the National Academy of Science USA 95:5061-5066.
11. Cohen BL. 1997. Lung cancer rate vs. mean radon level in U.S. counties of various characteristics. Health Physics Journal 72:114-119.
12. Covelli V, Dimajo V, Coppola M, Rabessi S. 1989. The dose response relationships for myeloid leukaemia and malignant lymphoma in BC3F mice. Radiation Research, 119:553-561.
13. Dasu A, Denekamp J. 2000. Inducible repair and intrinsic radiosensitivity: a complex but predictable relationship? Radiation Research 153:279-288.
14. 60 gamma rays and tritium beta particles. Radiation Research 51:229-243.
15. Feinendegen LE. 2003. Relative implications of protective responses versus damage induction at low dose and low-dose-rate exposures using microdose approach. Radiation Protection Dosimetry 104:337-346.
16. Feinendegen LE, Bond VP, Sondhaus CA. 2000. The dual response to low-dose irradiation: induction vs. prevention of DNA damage. In: Yamada T, editor. Biological effects of low dose radiation. Amsterdam: Elsevier Sciences B.V. pp 3-17.
17. Geard CR, Randers-Pehrson G, Hei TK, Jenkins GJ, Miller RC, Wu LJ, Brenner DJ, Hall EJ. 1997. In: Goodhead DT, O'Neill P, Menzel HG, editors. Microdosimetry, an interdisciplinary approach. Cambridge, UK: Royal Society Chemistry. pp 327-330.
18. Grosh S, Fritz G, Kaina B. 1998. Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Research 58:4410-4416.
19. Hall EJ. 2000. Radiobiology for the radiologist. New York: Lippincott Williams & Wilkins.
20. Hei TK, Wu LJ, Liu XZ, Vannais D, Waldren CA, Randers-Pehrson G. 1997. Mutagenic effects of a single and an exact number of α particles in mammalian cells. Proceedings of the National Academy of Science USA 94:3765-3770.
21. International Commission on Radiation Units and Measurements (ICRU). 1983. Microdosimetry ICRU Report 36, Bethesda, Maryland.
22. Kellerer AM, Chen J. 2003. Comparative microdosimetry of photoelectrons and compton electrons: an analysis in terms of generalized proximity functions. Radiation Research 160:324-333.
23. Kellerer AM. 1985. Fundamentals of microdosimetry. In: Ebert HG, editor. The dosimetry of ionizing radiation, Vol. I. San Diego, CA: Academic Press, Inc.
24. Kellerer AM. 1984. Chord-length distributions and related quantities for spheroids. Radiation Research 98:425-437.
25. Kellerer AM, Rossi HH. 1972. The theory of dual radiation action. In: Ebert M, Howard A, editors. Current Topics in Radiation Research Quarterly, Index Medicus. Amsterdam: North-Holland Publishers 8:85-158.
26. Leonard BE. 2000. Repair of multiple break chromosomal damage - its impact on the use of the linear-quadratic model for low dose and dose rates. In: University of Versailles, editor. The effects of low and very low doses of ionizing radiation on human health. Amsterdam: Elsevier Science B.V. pp 449-462.
27. Leonard BE. 2001a. Negative dose response to low level radiation: a quasi-threshold from initiation of radioresistance mechanisms for both spontaneous and radiation damage. Transactions American Nuclear Society 77:432-435.
28. Leonard BE. 2001b. Cell sensory and reaction to ionizing radiation - initiation and transition of repair mechanisms. Proceedings of the 2nd International Conference on the Effects of Low and Very Low Doses of Ionizing Radiation on Human Health, Dublin Institute of Technology, Dublin, Ireland, 02-4.
29. Leonard BE. 2006. Adaptive response: Part II. Modeling for dose rate and time influences. International Journal of Radiation Biology, In review.
30. Little MP, Wakeford R. 2001. The bystander effect in C3H 10T1/2 cells and radon induced lung cancer. Radiation Research 156:695-699.
31. Luchnik NV, Sevankaev AV. 1976. Radiation-induced chromosome aberrations in hyman lymphocytes. I. Dependence on the dose of gamma-rays and an anomaly at low doses. Mutation Research 36:363-378.
32. 2-phase cells. Radiation Research 161:247-255.
33. Miller RC, Hall EJ, Rossi HH. 1979. Oncogenic transformation of mammalian in vitro with split doses of x-rays. Proceedings of the National Academy of Science USA 76:5755-5758.
34. Miller RC, Randers-Pehren G, Geard CR, Hall EJ, Brenner DJ. 1999. The oncogenic transforming potential of the passage of single a particles through mammalian cell nuclei. Proceedings of the National Academy of Science 96:19-22.
35. National Council on Radiation Protection and Measurements. 1993. Limitation of exposure to ionizing radiation. NCRP Report No. 116. Bethesda, Maryland USA: National Council on Radiation Protection and Measurements.
36. Pohl-Rüling J. 1988. Chromosome aberrations in man in areas with elevated natural radioactivity. In: Proceedings XVth Bezelius Symposium on Somatic and Genetic Effects of Ionizing Radiation. Umea, Sweden. Bezelius Symposium XV, 103-111.
37. Pohl-Rüling J, Fischer P. 1979. The dose-effect relationship of chromosome aberrations to α and γ irradiation in a population subjected to an increased burden of natural radioactivity. Radiation Research 80:61-81.
38. Pohl-Rüling J, Fischer P, Haas O, Obe G, Natarajan AT, Van Buul PPW, Buckton KE, Bianchi NO, Larramendy M, Kucherova M, Polikova Z, Leonard A, Fabry L, Palitti F, Sharma T, Binder W, Mukherjee RN, Mikherjee U. 1983. Effect of low-dose acute x-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro. Mutation Research 110:71-82.
39. Pohl-Ruling J, Lettner H, Hofmann W, Eckl P, Haas OA, Obe G, Grell-Buchtmann I, Van Buul PPW, Schroeder-Kurth T, Atzmuller CH, Sasaki MS, Fischer P, Kublak R, Nataralan AT. 2000. Chromosome aberrations of blood lymphocytes induced in vitro by radon-222 daughter α-irradiation. Mutatation Research 449:7-19.
40. Randers-Pehrson G. 2002. Microbeams, microdosimetry and specific dose. Radiation Protection Dosimetry 99:471-472.
41. Redpath JL, Antonio RJ. 1998. Induction of an adaptive response against spontaneous neoplastic transformation in vitro by low-dose gamma radiation. Radiation Research 149:517-520.
42. Redpath JL, Liang D, Taylor TH, Christie C, Elmore B. 2001. The shape of the dose-response curve for radiation-induced neoplastic transformation in vitro, evidence for an adaptive response against neoplastic transformation at low doses of low-LET radiation. Radiation Research 156:700-707.
43. Redpath JL, Lu Q, Lao X, Molloi S, Elmore E. 2003. Low doses of diagnostic energy X-rays protect against neoplastic transformation in vitro. International Journal of Radiation Biology 79:235-240.
44. Rossi HH, Zaider M. 1997. Radiogenic lung cancer, the effects of low doses of low linear energy transfer (LET) radiation. Radiation and Environmental Biophysics 36/2:85-88.
45. Rossi HH. 1999. Risks from less than 1.0 millisievert. Radiation Protection Dosimetry 83:277-279.
46. Shadley JH, Wolff S. 1987. Very low doses of x-rays can cause human lymphocytes to become less susceptible to ionizing radiation. Mutagenesis 2:95-96.
47. Shimizu Y, Kato H, Schull WJ, Mabuchi K. 1992. Dose response analysis among atomic bomb survivors exposed to low level radiation. In: Low level irradiation and biological defense mechanisms. Amsterdam: Excerpta Medica. pp 71-74.
48. 3H] thymidine-induced adaptive response of human lymphocytes to subsequent doses of x-ray involves the induction of a chromosomal repair mechanism. Mutagenesis 1:375-380.
49. Van Pelt WR. 2003. Epidemiological associations among lung cancer, radon exposure and elevation above sea level - a reassessment of Cohen's county level radon study. Health Physics 85:397-403.
50. Zhou H, Randers-Pherson G, Geard CR, Brenner DJ, Hall EJ, Hei T. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research 160:512-516.