Chromosomal aberrations of blood lymphocytes induced in vitro by radon- 222 daughter α-irradiation

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 449, Issue 1-2, 2000, Pages 7-19

  Pohl Ruling J ^a   Lettner, H ^a   Hofmann, W ^a   Eckl, P ^a   Haas, O A ^b   Obe, G ⁱ   Grell Buchtmann I ^c   Van Buul, P P W ^d   Schroeder Kurth, T ^e   Atzmüller, Ch ^a   Sasaki, M S ^f   Fischer, P ^g   Kubiak, R ^h   Natarajan, A T ^d  

^a UNIVERSITY OF SALZBURG   (Austria)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

^c UNIVERSITY OF BREMEN   (Germany)

^d LEIDEN UNIVERSITY   (Netherlands)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f KYOTO UNIVERSITY   (Japan)

^g ANIMAL HEALTH TRUST   (United Kingdom)

^h JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

ⁱ Collegium Medicum Jagiellonian U ^*

Author keywords

Chromosomal aberrations; Nonlinear low dose response; Radon daughter 214Po low level irradiation

Indexed keywords

RADON 222; RADON DAUGHTER;

ALPHA RADIATION; ARTICLE; CHERNOBYL ACCIDENT; CHROMOSOME ABERRATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; LYMPHOCYTOTOXICITY; METAPHASE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION MUTAGENESIS; RADIATION RESPONSE;

ACCIDENTS, RADIATION; ALPHA PARTICLES; CHROMOSOME ABERRATIONS; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; LIPID PEROXIDATION; LYMPHOCYTES; POWER PLANTS; RADON; TIME FACTORS; UKRAINE;

EID: 0342657114     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00009-9     Document Type: Article

References (41)

1. Pohl E., Pohl-Rüling J. Dose calculations due to the inhalation of Rn222, Rn220 and their daughters. Health Phys. 32:1977;552-555.
2. Pohl-Rüling J., Fischer P. The dose-effect relationship of chromosome aberrations to alpha- and gamma-irradiation in a population subjected to an increased burden of natural radioactivity. Radiat. Res. 80:1979;61-81.
3. Pohl-Rüling J., Fischer P. Chromosome aberrations in inhabitants of areas with elevated natural radioactivity. Ishihara T., Sasaki M.S. Radiation-Induced Chromosome Damage in Man. 1983;527-560 A.R. Liss, New York.
4. Pohl-Rüling J., Fischer P., Pohl E. The effect of radon decay products on peripheral blood chromosomes. Hopke K. Proceedings of the 191st Meeting of the American Chemical Society, Symposium on Radon and its Decay Products, New York:1986;487-501.
5. Pohl-Rüling J. Chromosome aberrations in man in areas with elevated natural radioactivity. Tryckeri N. Proceedings of the XVth Berzelius Symposium on Somatic and Genetic Effects of Ionizing Radiation, Umea, Sweden, November:1988;103-111.
6. Pohl-Rüling J. Chromosome aberrations of blood lymphocytes induced by low-level doses of ionizing radiation. Obe G. Advances in Mutagenesis Research. Vol. 2:1990;155-190 Springer, Berlin.
7. 7Li reaction. Mutat. Res. 18:1973;103-111.
8. 241Am. Health Phys. 37:1979;279-289.
9. Purrot R.J., Edwards A.A., Lloyd D.C., Stather J.W. The induction of chromosomes aberrations by in vitro α-particles from plutonium-239. Int. J. Radiat. Biol. 80:1980;277-284.
10. Edwards A.A., Purrott R.J., Prosser J.S., Lloyd D.C. The induction of chromosome aberrations in human lymphocytes by alpha-radiation. Int. J. Radiat. Biol. 38:1980;83-91.
11. Schmid E., Hieber L., Heinzmann U., Roos H., Kellerer A.M. Analysis of chromosome aberrations in human peripheral lymphocytes induced by in vitro α-particle irradiation. Radiat. Environ. Biophys. 35:1996;179-184.
12. Pohl-Rüling J., Fischer P., Haas O., Obe G., Natarajan A.T., van Buul P.P., Buckton K.E., Bianchi N.O., Larramendy M., Kucerová M., Poliková Z., Lèonard A., Fabri L., Sharma T., Binder W., Mukherjee R.N., Mukherjee U. Effect of low-dose acute X-irradiation on the frequencies of chromosomal aberrations in human peripheral lymphocytes in vitro. Mutat. Res. 110:1983;71-82.
13. Lloyd D.C., Edwards A.A., Léonard A., Deknut G., Natarajan A., Obe G., Palitti F., Tanzarella A., Tawn E.J. Frequencies of chromosomal aberrations induced in human blood lymphocytes by low doses of X-rays. Int. J. Radiat. Biol. 53:1988;49-55.
14. Lloyd D.C., Edwards A.A., Lèonard A., Deknudt G.L., Verschaeve L., Natarajan A., Darrudi F., Obe G., Palitti F., Tanzarella C., Tawn E.J. Chromosomal aberrations in human lymphocytes induced in vitro by very low doses of X-rays. Int. J. Radiat. Biol. 61:1992;335-343.
15. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Annals of the ICRP. 21:1991;1-3.
16. Pohl-Rüling J. Low-dose effect on blood chromosomes. Sugahara T., Sagan L.A., Aoyama T. Low-Dose Irradiation and Biological Defense Mechanisms. 1992;121-124 Excerpta Medica, Amsterdam.
17. Pohl-Rüling J. Low-level dose-induced chromosome aberrations in human blood lymphocytes. Radiat. Prot. Dosim. 45:1992;623-628.
18. Eckl P.M., Anderson-Carnahan L., Jirtle R.L. Aquatic genotoxicity testing with rat hepatocytes in primary culture: I. SCE induction. Sci. Total Environ. 135:1993;111-119.
19. Nagasawa H., Little J.B. Induction of sister chromatid exchanges by extremely low doses of α-particles. Cancer Res. 52:1992;6394-6396.
20. Rossi H., Zaider M. Radiogenic lung cancer. Radiat. Environ. Biophys. 36:1997;85-88.
21. Tuschl H., Altmann H., Kovac R., Topaloglou A., Egg D., Günther R. Effects of low-dose radiation on repair processes in human lymphocytes. Radiat. Res. 81:1980;1-9.
22. Elkind M.M. Repair processes in radiation biology. Radiat. Res. 100:1984;425-449.
23. Elkind M.M. Cellular transformation. Int. J. Radiat. Biol. 57:1990;407-423.
24. Crawford-Brown D.J., Hofmann W. Extension of a generalized state vector model of radiation carcinogenesis to consideration of dose rate. Math. Biosci. 115:1993;123-144.
25. Katz R., Hofmann W. Biological effects of low doses of ionizing radiations: particle tracks in radiobiology. Nucl. Instrum. Methods. 203:1982;433-442.
26. Hohn-Elkarim K., Mühlensiepen H., Altman K.I., Feinendegen L.E. Modification of effects of radiation on thymidine kinase. Int. J. Radiat. Biol. 58:1990;97-110.
27. Oftedal P. Biological low-dose radiation effects. Mutat. Res. 258:1991;191-205.
28. Pohl-Rüling J., Pohl E. Method for α-irradiation of blood cultures with short-lived radon-222 decay products. Mutat. Res. 234:1990;43-45.
29. Jostes R.F., Hui T.E., James A.C., Cross F.T., Schwartz J.L., Rotmensch J., Atcher R.W., Evans H.H., Mencl J., Bacale G., Rao P.S. In vitro exposure of mammalian cells to radon: dosimetric considerations. Radiat. Res. 127:1991;211-219.
30. Meyer St., Schweidler E. Radioaktivität: 2. Auflage. 1927;359-360 Verlag B.G. Teubner, Berlin.
31. Israel H. Barth Radioaktivität. 1940;20. Leipzig.
32. Buckton K.E., Evans H.J. Method for the analysis of human chromosome aberrations. Buckton K.E., Evans H.J. WHO International Reference, Centre for Chromosome Aberrations: Evaluation in Population. 1973;1-66 World Health Organization, Geneva.
33. E. Pohl, F. Steinhäusler, W. Hofmann. Die natürliche Strahlenexposition der Bevölkerung der Stadt Salzburg. Ergebnisse einer vierjährigen Untersuchung des Institutes für Physik für Bio-und Geowissenschaften, in: Universitätsdruckerei Pustet (Ed.), Jahrbuch 1975-77 der Universität Salzburg, Salzburg, 1978, pp. 105-116.
34. Steinhäusler F., Hofmann W., Daschil F., Reubel B. Chernobyl and its radiological consequences for the Province of Salzburg, Austria. Environ. Int. 14:1988;91-111. Special issue.
35. Lettner H., Bossew P., Hubner A.K. Kontamination durch radioaktiven Fallout im Bundesland Salzburg und in angrenzenden Teilen von Oberösterreich. Umweltsbundesamt Reports UBA 94. 101:1994;1-63. Wien.
36. Pohl-Rüling J., Haas O.A., Brøgger A., Obe G., Lettner H., Daschil F., Atzmüller C., Lloyd D., Kubiak R., Natarajan A.T. The effect on lymphocyte chromosomes of additional radiation burden due to fallout in Salzburg (Austria) from the Chernobyl accident. Mutat. Res. 262:1991;209-217.
37. Gastberger M., Lettner H., Hofmann W., Pohl-Rüling J., Steinhäusler F., Hubner A. Impact of the Chernobyl fallout in the alpine environment. IAEA TECDOC-9. 2:1997;158-165. Poster presentation in "One decade after Chernobyl: summing of the consequences of the accident"
38. Eckl P.M., Ortner A., Esterbauer H. Genotoxic properties of 4-hydroxy-alkenals and analogous aldehydes. Mutat. Res. 290:1993;183-192.
39. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. 1989;Oxford Univ. Press.
40. Keyse S.M., Tyrrell R.M. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide and sodium arsenite. Proc. Natl. Acad. Sci. USA. 86:1989;99-103.
41. Keyse S.M., Applegate L.A., Tromvoukis Y., Tyrrell R.M. Oxidant stress leads to transcriptional activation of the human heme oxygenase gene in cultured skin fibroblasts. Mol. Cell Biol. 10:1990;4967-4969.