메뉴 건너뛰기




Volumn 6, Issue 2, 2006, Pages 131-144

Manipulating glutathione-S-transferases may prevent the development of tolerance to nitroglycerin

Author keywords

Drug tolerance; Endothelium; Glutathione S transferase (GST); Nitroglycerin (NTG); Vascular smooth muscle cell, oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; COMPLEMENTARY DNA; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTATHIONE TRANSFERASE A4; GLYCERYL TRINITRATE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE;

EID: 33847095011     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:6:2:131     Document Type: Article
Times cited : (10)

References (43)
  • 1
    • 26244465889 scopus 로고    scopus 로고
    • Explaining the phenomenon of nitrate tolerance
    • Munzel, T., Daiber, A., and Mulsch, A. (2005). Explaining the phenomenon of nitrate tolerance. Circ. Res. 97(7):618-628.
    • (2005) Circ. Res , vol.97 , Issue.7 , pp. 618-628
    • Munzel, T.1    Daiber, A.2    Mulsch, A.3
  • 2
    • 0347758408 scopus 로고    scopus 로고
    • Roles of superoxide, peroxynitrite, and protein kinase C in the development of tolerance to nitroglycerin
    • bou-Mohamed, G., Johnson, J.A., Jin, L., et al. (2004). Roles of superoxide, peroxynitrite, and protein kinase C in the development of tolerance to nitroglycerin. J. Pharmacol. Exp. Ther. 308(1):289-299.
    • (2004) J. Pharmacol. Exp. Ther , vol.308 , Issue.1 , pp. 289-299
    • bou-Mohamed, G.1    Johnson, J.A.2    Jin, L.3
  • 3
    • 0037027487 scopus 로고    scopus 로고
    • Nitrate tolerance: A unifying hypothesis
    • Gori, T. and Parker, J.D.(2002) Nitrate tolerance: a unifying hypothesis. Circulation 106(19):2510-2513.
    • (2002) Circulation , vol.106 , Issue.19 , pp. 2510-2513
    • Gori, T.1    Parker, J.D.2
  • 4
    • 0034061802 scopus 로고    scopus 로고
    • Role of L-arginine in the vascular actions and development of tolerance to nitroglycerin
    • bou-Mohamed, G., Kaesemeyer, W.H., Caldwell, R.B., and Caldwell, R.W. (2000). Role of L-arginine in the vascular actions and development of tolerance to nitroglycerin. Br. J. Pharmacol. 130(2):211-218.
    • (2000) Br. J. Pharmacol , vol.130 , Issue.2 , pp. 211-218
    • bou-Mohamed, G.1    Kaesemeyer, W.H.2    Caldwell, R.B.3    Caldwell, R.W.4
  • 5
    • 0037334138 scopus 로고    scopus 로고
    • Mechanism-based partial inactivation of glutathione S-transferases by nitroglycerin: Tyrosine nitration vs sulfhydryl oxidation
    • Lee, W.I. and Fung, H.L. (2003). Mechanism-based partial inactivation of glutathione S-transferases by nitroglycerin: tyrosine nitration vs sulfhydryl oxidation. Nitric Oxide 8(2):103-110.
    • (2003) Nitric Oxide , vol.8 , Issue.2 , pp. 103-110
    • Lee, W.I.1    Fung, H.L.2
  • 6
    • 0035887291 scopus 로고    scopus 로고
    • Inactivation of glutathione S-transferases by nitric oxide-derived oxidants: Exploring a role for tyrosine nitration
    • Wong, P.S., Eiserich, J.P., Reddy, S., Lopez C.L., Cross C.E., van der Vilet, A. (2001). Inactivation of glutathione S-transferases by nitric oxide-derived oxidants: exploring a role for tyrosine nitration. Arch. Biochem. Biophys. 394(2):216-228.
    • (2001) Arch. Biochem. Biophys , vol.394 , Issue.2 , pp. 216-228
    • Wong, P.S.1    Eiserich, J.P.2    Reddy, S.3    Lopez, C.L.4    Cross, C.E.5    van der Vilet, A.6
  • 7
    • 0030273403 scopus 로고    scopus 로고
    • Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin
    • Singhal, S.S., Piper, J.T., Srivastava, S.K., et al. (1996) Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin. Toxicol. Appl. Pharmacol. 140(2):378-386.
    • (1996) Toxicol. Appl. Pharmacol , vol.140 , Issue.2 , pp. 378-386
    • Singhal, S.S.1    Piper, J.T.2    Srivastava, S.K.3
  • 8
    • 0028864861 scopus 로고
    • Tolerance to nitroglycerin in vascular smooth muscle cells is not affected by the level of intracellular glutathione or L-cysteine
    • Newman, W.H., Zhang, L.M., McDonald, M.H., Jollow, D.J., and Castresana, M.R. (1995). Tolerance to nitroglycerin in vascular smooth muscle cells is not affected by the level of intracellular glutathione or L-cysteine. Anesth. Analg. 81(6):1229-1234.
    • (1995) Anesth. Analg , vol.81 , Issue.6 , pp. 1229-1234
    • Newman, W.H.1    Zhang, L.M.2    McDonald, M.H.3    Jollow, D.J.4    Castresana, M.R.5
  • 9
    • 1342281276 scopus 로고    scopus 로고
    • Biochemical mechanism of nitroglycerin action and tolerance: Is this old mystery solved?
    • Fung, H.L. (2004). Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved? Annu. Rev. Pharmacol. Toxicol. 44:67-85.
    • (2004) Annu. Rev. Pharmacol. Toxicol , vol.44 , pp. 67-85
    • Fung, H.L.1
  • 10
    • 0141839064 scopus 로고    scopus 로고
    • Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina
    • Hirai, N., Kawano, H., Yasue, H., et al. (2003). Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina. Circulation 108(12):1446-1450.
    • (2003) Circulation , vol.108 , Issue.12 , pp. 1446-1450
    • Hirai, N.1    Kawano, H.2    Yasue, H.3
  • 11
    • 1842636201 scopus 로고    scopus 로고
    • Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: Possible role in human atherosclerosis
    • Yang, Y., Yang, Y., Trent, M.B., et al. (2004). Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis. Atherosclerosis 173(2):211-221.
    • (2004) Atherosclerosis , vol.173 , Issue.2 , pp. 211-221
    • Yang, Y.1    Yang, Y.2    Trent, M.B.3
  • 12
    • 0034811649 scopus 로고    scopus 로고
    • Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues
    • Cheng, J.Z., Yang, Y., Singh, S.P., et al. (2001). Two distinct 4-hydroxynonenal metabolizing glutathione S-transferase isozymes are differentially expressed in human tissues. Biochem. Biophys. Res. Commun. 282(5):1268-1274.
    • (2001) Biochem. Biophys. Res. Commun , vol.282 , Issue.5 , pp. 1268-1274
    • Cheng, J.Z.1    Yang, Y.2    Singh, S.P.3
  • 13
    • 0031104709 scopus 로고    scopus 로고
    • Increased resistance to oxidative stress in transfected cultured cells overexpressing glutathione S-transferase mGSTA4-4
    • Zimniak, L., Awasthi, S., Srivastava, S.K., and Zimniak, P. (1997). Increased resistance to oxidative stress in transfected cultured cells overexpressing glutathione S-transferase mGSTA4-4. Toxicol. Appl. Pharmacol. 143(1):221-229.
    • (1997) Toxicol. Appl. Pharmacol , vol.143 , Issue.1 , pp. 221-229
    • Zimniak, L.1    Awasthi, S.2    Srivastava, S.K.3    Zimniak, P.4
  • 14
    • 0007996162 scopus 로고    scopus 로고
    • The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall
    • He, N.G., Awasthi, S., Singhal, S.S., Trent, M.B., and Boor, P.J. (1998). The role of glutathione S-transferases as a defense against reactive electrophiles in the blood vessel wall. Toxicol. Appl. Pharmacol. 152(1):83-89.
    • (1998) Toxicol. Appl. Pharmacol , vol.152 , Issue.1 , pp. 83-89
    • He, N.G.1    Awasthi, S.2    Singhal, S.S.3    Trent, M.B.4    Boor, P.J.5
  • 15
    • 0033566203 scopus 로고    scopus 로고
    • Role of glutathione S-transferase 8-8 in allylamine resistance of vascular smooth muscle cells in vitro
    • He, N., Singhal, S.S., Awasthi, S., Zhao, T., and Boor, P.J. (1999). Role of glutathione S-transferase 8-8 in allylamine resistance of vascular smooth muscle cells in vitro. Toxicol. Appl. Pharmacol. 158(2):177-185.
    • (1999) Toxicol. Appl. Pharmacol , vol.158 , Issue.2 , pp. 177-185
    • He, N.1    Singhal, S.S.2    Awasthi, S.3    Zhao, T.4    Boor, P.J.5
  • 16
    • 0023224441 scopus 로고
    • Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery
    • Rapoport, R.M., Waldman, S.A., Ginsburg, R., Molina, C.R., and Murad, F. (1987). Effects of glyceryl trinitrate on endothelium-dependent and -independent relaxation and cyclic GMP levels in rat aorta and human coronary artery. J. Cardiovasc. Pharmacol. 10(1):82-89.
    • (1987) J. Cardiovasc. Pharmacol , vol.10 , Issue.1 , pp. 82-89
    • Rapoport, R.M.1    Waldman, S.A.2    Ginsburg, R.3    Molina, C.R.4    Murad, F.5
  • 17
    • 0141671852 scopus 로고    scopus 로고
    • Endothelial modulation and tolerance development in the vasorelaxant responses to nitrate of rabbit aorta
    • Nakae, I., Matsumoto, T., Omura, T., et al. (2003). Endothelial modulation and tolerance development in the vasorelaxant responses to nitrate of rabbit aorta. Life Sci. 73(24):3083-3094.
    • (2003) Life Sci , vol.73 , Issue.24 , pp. 3083-3094
    • Nakae, I.1    Matsumoto, T.2    Omura, T.3
  • 18
    • 0027528328 scopus 로고
    • Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development
    • Chung, S.J. and Fung, H.L. (1993). Relationship between nitroglycerin-induced vascular relaxation and nitric oxide production. Probes with inhibitors and tolerance development. Biochem. Pharmacol. 45(1):157-163.
    • (1993) Biochem. Pharmacol , vol.45 , Issue.1 , pp. 157-163
    • Chung, S.J.1    Fung, H.L.2
  • 19
    • 0036032938 scopus 로고    scopus 로고
    • Effects of glutathione S-transferase inhibitors on nitroglycerin action in pig isolated coronary arteries
    • Matsuzaki, T., Sakanashi, M., Nakasone, J., et al. (2002). Effects of glutathione S-transferase inhibitors on nitroglycerin action in pig isolated coronary arteries. Clin. Exp. Pharmacol. Physiol. 29(12):1091- 1095.
    • (2002) Clin. Exp. Pharmacol. Physiol , vol.29 , Issue.12 , pp. 1091-1095
    • Matsuzaki, T.1    Sakanashi, M.2    Nakasone, J.3
  • 20
    • 0032857976 scopus 로고    scopus 로고
    • Absence of nitrate tolerance after long-term treatment with ramipril: An endothelium-dependent mechanism
    • Berkenboom, G., Fontaine, D., Unger, P., Baldassarre, S., Preumont, N., and Fontaine, J. (1999) Absence of nitrate tolerance after long-term treatment with ramipril: an endothelium-dependent mechanism. J. Cardiovasc. Pharmacol. 34(4):547-553.
    • (1999) J. Cardiovasc. Pharmacol , vol.34 , Issue.4 , pp. 547-553
    • Berkenboom, G.1    Fontaine, D.2    Unger, P.3    Baldassarre, S.4    Preumont, N.5    Fontaine, J.6
  • 21
    • 0032783532 scopus 로고    scopus 로고
    • Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2′,7′- dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′- dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123
    • Hempel, S.L., Buettner, G.R., O'Malley, Y.Q., Wessels, D.A., and Flaherty, D.M. (1999). Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′- dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′- dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic. Biol. Med. 27(1-2):146-159.
    • (1999) Free Radic. Biol. Med , vol.27 , Issue.1-2 , pp. 146-159
    • Hempel, S.L.1    Buettner, G.R.2    O'Malley, Y.Q.3    Wessels, D.A.4    Flaherty, D.M.5
  • 22
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 24
  • 25
    • 0032990560 scopus 로고    scopus 로고
    • Endothelial dysfunction in human disease
    • Drexler, H. and Hornig, B. (1999). Endothelial dysfunction in human disease. J. Mol. Cell Cardiol. 31(1):51-60.
    • (1999) J. Mol. Cell Cardiol , vol.31 , Issue.1 , pp. 51-60
    • Drexler, H.1    Hornig, B.2
  • 26
    • 0034614284 scopus 로고    scopus 로고
    • Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability
    • Munzel, T., Li, H., Mollnau, H., et al. (2000). Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability. Circ. Res. 86(1):E7-E12.
    • (2000) Circ. Res , vol.86 , Issue.1
    • Munzel, T.1    Li, H.2    Mollnau, H.3
  • 27
    • 0345375257 scopus 로고    scopus 로고
    • Nitrate tolerance and the links with endothelial dysfunction and oxidative stress
    • Fayers, K.E., Cummings, M.H., Shaw, K.M., and Laight, D.W. (2003). Nitrate tolerance and the links with endothelial dysfunction and oxidative stress. Br. J. Clin. Pharmacol. 56(6):620-628.
    • (2003) Br. J. Clin. Pharmacol , vol.56 , Issue.6 , pp. 620-628
    • Fayers, K.E.1    Cummings, M.H.2    Shaw, K.M.3    Laight, D.W.4
  • 28
    • 0030573171 scopus 로고    scopus 로고
    • Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells
    • He, N.G., Singhal, S.S., Chaubey, M., et al. (1996). Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells. Biochim. Biophys. Acta 1291(3):182-188.
    • (1996) Biochim. Biophys. Acta , vol.1291 , Issue.3 , pp. 182-188
    • He, N.G.1    Singhal, S.S.2    Chaubey, M.3
  • 29
    • 0034823792 scopus 로고    scopus 로고
    • Peroxynitrite causes endothelial cell monolayer barrier dysfunction
    • Knepler, J.L., Jr., Taher, L.N., Gupta, M.P., et al. (2001). Peroxynitrite causes endothelial cell monolayer barrier dysfunction. Am. J. Physiol. Cell Physiol. 281(3):C1064-C1075.
    • (2001) Am. J. Physiol. Cell Physiol , vol.281 , Issue.3
    • Knepler Jr., J.L.1    Taher, L.N.2    Gupta, M.P.3
  • 30
    • 0036812989 scopus 로고    scopus 로고
    • Mechanisms underlying nitrate-induced endothelial dysfunction: Insight from experimental and clinical studies
    • Warnholtz, A., Tsilimingas, N., Wendt, M., and Munzel, T. (2002). Mechanisms underlying nitrate-induced endothelial dysfunction: insight from experimental and clinical studies. Heart Fail. Rev. 7(4):335-345.
    • (2002) Heart Fail. Rev , vol.7 , Issue.4 , pp. 335-345
    • Warnholtz, A.1    Tsilimingas, N.2    Wendt, M.3    Munzel, T.4
  • 31
    • 0026595087 scopus 로고
    • Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase
    • Hill, K.E., Hunt, R.W. Jr., Jones, R., Hoover, R.L., and Burk, R.F. (1992). Metabolism of nitroglycerin by smooth muscle cells. Involvement of glutathione and glutathione S-transferase. Biochem. Pharmacol. 43(3):561-566.
    • (1992) Biochem. Pharmacol , vol.43 , Issue.3 , pp. 561-566
    • Hill, K.E.1    Hunt Jr., R.W.2    Jones, R.3    Hoover, R.L.4    Burk, R.F.5
  • 32
    • 0028104348 scopus 로고
    • Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase
    • Kenkare, S.R., Han, C., and Benet, L.Z. (1994). Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase. Biochem. Pharmacol. 48(12):2231-2235.
    • (1994) Biochem. Pharmacol , vol.48 , Issue.12 , pp. 2231-2235
    • Kenkare, S.R.1    Han, C.2    Benet, L.Z.3
  • 33
    • 0029923895 scopus 로고    scopus 로고
    • Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases
    • Kenkare, S.R. and Benet, L.Z. (1996). Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases. Biochem. Pharmacol. 51(10):1357-1363.
    • (1996) Biochem. Pharmacol , vol.51 , Issue.10 , pp. 1357-1363
    • Kenkare, S.R.1    Benet, L.Z.2
  • 34
    • 11144226987 scopus 로고    scopus 로고
    • Role of peroxynitrite in the process of vascular tone regulation by nitric oxide and prostanoids - a nanotechnological approach
    • Kozak, A.J., Liu, F., Funovics, P., Jacoby, A., Kubant, R., and Malinski, T. (2005). Role of peroxynitrite in the process of vascular tone regulation by nitric oxide and prostanoids - a nanotechnological approach. Prostaglandins Leukot. Essent. Fatty Acids 72(2):105-113.
    • (2005) Prostaglandins Leukot. Essent. Fatty Acids , vol.72 , Issue.2 , pp. 105-113
    • Kozak, A.J.1    Liu, F.2    Funovics, P.3    Jacoby, A.4    Kubant, R.5    Malinski, T.6
  • 35
    • 4544240360 scopus 로고    scopus 로고
    • Bioactivation of nitroglycerin to nitric oxide (NO) and S-nitrosothiols in the rat liver and evaluation of the coexisting hypotensive effect
    • Sokolowska, M., Bednarski, M., Kwiecien, I., Filipek, B., and Wlodek, L. (2004). Bioactivation of nitroglycerin to nitric oxide (NO) and S-nitrosothiols in the rat liver and evaluation of the coexisting hypotensive effect. Fundam. Clin. Pharmacol. 18(4):449-456.
    • (2004) Fundam. Clin. Pharmacol , vol.18 , Issue.4 , pp. 449-456
    • Sokolowska, M.1    Bednarski, M.2    Kwiecien, I.3    Filipek, B.4    Wlodek, L.5
  • 36
    • 1442324343 scopus 로고    scopus 로고
    • Peroxynitrite induces apoptosis in rat aortic smooth muscle cells: Possible relation to vascular diseases
    • Li, J., Li, W., Su, J., Liu, W., Altura, B.T., and Altura, B.M. (2004). Peroxynitrite induces apoptosis in rat aortic smooth muscle cells: possible relation to vascular diseases. Exp. Biol. Med. (Maywood) 229(3):264-269.
    • (2004) Exp. Biol. Med. (Maywood) , vol.229 , Issue.3 , pp. 264-269
    • Li, J.1    Li, W.2    Su, J.3    Liu, W.4    Altura, B.T.5    Altura, B.M.6
  • 37
    • 0036199685 scopus 로고    scopus 로고
    • Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    • Zou, M.H., Shi, C., and Cohen, R.A. (2002). Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J. Clin. Invest. 109(6):817-826.
    • (2002) J. Clin. Invest , vol.109 , Issue.6 , pp. 817-826
    • Zou, M.H.1    Shi, C.2    Cohen, R.A.3
  • 38
    • 0036080603 scopus 로고    scopus 로고
    • Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells
    • Cooke, C.L. and Davidge, S.T. (2002). Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthase in endothelial cells. Am. J. Physiol. Cell Physiol. 282(2):C395-C402.
    • (2002) Am. J. Physiol. Cell Physiol , vol.282 , Issue.2
    • Cooke, C.L.1    Davidge, S.T.2
  • 40
    • 0037066021 scopus 로고    scopus 로고
    • Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment
    • Schulz, E., Tsilimingas, N., Rinze, R., et al.(2002) Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation 105(10):1170-1175.
    • (2002) Circulation , vol.105 , Issue.10 , pp. 1170-1175
    • Schulz, E.1    Tsilimingas, N.2    Rinze, R.3
  • 41
    • 0027455003 scopus 로고
    • Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells
    • Salvemini, D., Pistelli, A., and Vane, J. (1993). Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells. Br. J. Pharmacol. 108(1):162-169.
    • (1993) Br. J. Pharmacol , vol.108 , Issue.1 , pp. 162-169
    • Salvemini, D.1    Pistelli, A.2    Vane, J.3
  • 42
    • 0029827822 scopus 로고    scopus 로고
    • In vivo nitrate tolerance is not associated with reduced bioconversion of nitroglycerin to nitric oxide
    • Laursen, J.B., Mulsch, A., Boesgaard, S., et al. (1996). In vivo nitrate tolerance is not associated with reduced bioconversion of nitroglycerin to nitric oxide. Circulation 94(9):2241-2247.
    • (1996) Circulation , vol.94 , Issue.9 , pp. 2241-2247
    • Laursen, J.B.1    Mulsch, A.2    Boesgaard, S.3
  • 43
    • 2942574528 scopus 로고    scopus 로고
    • NO suppresses while peroxynitrite sustains NF-kappaB: A paradigm to rationalize cytoprotective and cytotoxic actions attributed to
    • Hattori, Y., Kasai, K., and Gross, S.S. (2004). NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovasc. Res. 63(1):31-40.
    • (2004) Cardiovasc. Res , vol.63 , Issue.1 , pp. 31-40
    • Hattori, Y.1    Kasai, K.2    Gross, S.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.