Adaptation or selection? Old issues and new stakes in the postwar debates over bacterial drug resistance

Studies in History and Philosophy of Science Part C :Studies in History and Philosophy of Biological and Biomedical Sciences

Volumn 38, Issue 1, 2007, Pages 159-190

  Creager, Angela N H ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

Antibiotic resistance; Bacterial genetics; Bacteriology; Evolution; Neo Darwinian synthesis; Plasmid

Indexed keywords

ANTIINFECTIVE AGENT;

ADAPTATION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIOLOGY; BACTERIUM; COMPARATIVE STUDY; DRUG EFFECT; EVOLUTION; EXTRACHROMOSOMAL INHERITANCE; GENETIC SELECTION; GENETICS; HUMAN; MICROBIAL GENETICS; MULTIDRUG RESISTANCE; MUTATION; PENICILLIN RESISTANCE; R FACTOR;

ADAPTATION, BIOLOGICAL; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIOLOGY; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; EVOLUTION; EXTRACHROMOSOMAL INHERITANCE; GENETICS, MICROBIAL; HUMANS; MUTATION; PENICILLIN RESISTANCE; R FACTORS; SELECTION (GENETICS);

EID: 33847094182     PISSN: 13698486     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.shpsc.2006.06.016     Document Type: Article

References (179)

1. Abraham E.P., Chain E., Fletcher C.M., Gardner A.D., Heatley N.G., Jennings M.A., and Florey H.W. Further observations on penicillin. Lancet 2 (1941) 177-189
2. Adams M. Science, ideology, and structure: The Kol'tsov Institute, 1900-1970. In: Lubrano L.L., and Solomon S.G. (Eds). The social context of Soviet science (1980), Westview Press, Boulder, CO 173-204
3. Akiba T., Koyama K., Ishiki Y., Kimura S., and Fukushima T. On the mechanism of the development of multiple-drug-resistant clones of Shigella. Japanese Journal of Microbiology 4 (1960) 219-227
4. Amsterdamska O. Medical and biological constraints: Early research on variation in bacteriology. Social Studies of Science 17 (1987) 657-687
5. Amsterdamska O. Stabilizing instability: The controversy over cyclogenic theories of bacterial variation during the interwar period. Journal of the History of Biology 24 (1991) 191-222
6. Amsterdamska O. From pneumonia to DNA: The research career of Oswald T. Avery. Historical Studies in the Physical and Biological Sciences 24 (1993) 1-40
7. Arkwright J.A. Variation in bacteria in relation to agglutination both by salts and by specific serum. Journal of Pathology and Bacteriology 24 (1921) 36-60
8. Arkwright, J. A. (1930). Variation. In Medical Research Council (Great Britain), A system of bacteriology in relation to medicine, Vol. 1 (pp. 311-374). London: His Majesty's Stationery Office.
9. Avery O.T., MacLeod C.M., and McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Journal of Experimental Medicine 79 (1944) 137-158
10. Bailey J.H., and Cavallito C.J. Antibiotics. Annual Review of Microbiology 2 (1948) 143-182
11. Barnett J. A history of research on yeasts 7: Enzymic adaptation and regulation. Yeast 21 (2004) 703-746
12. Beadle G.W. Biochemical genetics. Chemical Reviews 37 (1945) 15-96
13. Bivins R. Sex cells: Gender and the language of bacterial genetics. Journal of the History of Biology 33 (2000) 113-139
14. Bolivar R., Rodriguez R.L., Greene P.J., Betlach M.C., Heynecker H.L., Boyer H.W., Crosa J.H., and Falkow S. Construction and characterization of new cloning vehicles, II. A multipurpose cloning system. Gene 2 (1977) 95-113
15. Boyer H.W. DNA restriction and modification mechanisms in bacteria. Annual Review of Microbiology 25 (1971) 153-176
16. Brock T.D. The emergence of bacterial genetics (1990), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
17. Bud R. Penicillin and the new Elizabethans. British Journal for the History of Science 31 (1998) 305-333
18. In: Cairns J., Stent G.S., and Watson J.D. (Eds). Phage and the origins of molecular biology (1966), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
19. Cavalli-Sforza L.L. Indirect selection and origin of resistance. In: Wolstenholme G.E.W., and O'Connor C.M. (Eds). Ciba Foundation symposium on drug resistance in micro-organisms: Mechanisms of development (1957), Little, Brown & Company, Boston, MA 30-40
20. Cavalli-Sforza L.L., and Lederberg J. Isolation of pre-adaptive mutants in bacteria by sib selection. Genetics 41 (1956) 367-381
21. Chain E. The development of bacterial chemotherapy. Antibiotics & Chemotherapy 4 (1954) 215-241
22. Cohen S.N. Bacterial plasmids: Their extraordinary contribution to molecular genetics. Gene 135 (1993) 67-76
23. Cohen, S. N., Chang, A. C. Y., & Hsu, L. (1972). Nonchromosomal antibiotic resistance in bacteria: Genetic transformation of Escherichia coli. Proceedings of the National Academy of Sciences, USA, 69, 2110-2114.
24. Cohen, S. N., Chang, A. C. Y., Boyer, H. W., & Helling, R. B. (1973). Construction of biologically functional bacterial plasmids in vitro. Proceedings of the National Academy of Sciences, USA, 70, 3240-3244.
25. Cohn M., Monod J., Pollock M.R., Spiegelman S., and Stanier R.Y. Terminology of enzyme formation. Nature 172 (1953) 1096
26. Cole L.J., and Wright W.H. Application of the pure-line concept to bacteria. Journal of Infectious Diseases 19 (1916) 209-221
27. Creager A.N.H. The life of a virus: Tobacco mosaic virus as an experimental model, 1930-1965 (2002), University of Chicago Press, Chicago, IL
28. Creager A.N.H. Mapping genes in microorganisms. In: Gaudillière J.-P., and Rheinberger H.-J. (Eds). From molecular genetics to genomics: The mapping cultures of twentieth-century genetics (2004), Routledge, London & New York 9-41
29. Cutting W.C. Actions of antibiotics in vivo. Annual Review of Microbiology 3 (1949) 137-158
30. Darlington C.D. Heredity, development and infection. Nature 154 (1944) 164-169
31. Davis B.D. Isolation of biochemically deficient mutants by penicillin. Journal of the American Chemical Society 70 (1948) 4267
32. Dean A.C.R., and Hinshelwood C. Aspects of the problem of drug resistance in bacteria. In: Wolstenholme G.E.W., and O'Connor C.M. (Eds). Ciba Foundation symposium on drug resistance in micro-organisms: Mechanisms of development (1957), Little, Brown & Company, Boston, MA 4-23
33. De Chadarevian S. Designs for life: Molecular biology after World War II (2002), Cambridge University Press, Cambridge
34. Demerec, M. (1943). Director's Report, Department of Genetics. Carnegie Institution of Washington Yearbook, 42, 123-161.
35. Demerec, M. (1944). Director's Report, Department of Genetics. Carnegie Institution of Washington Yearbook, 43, 103-155.
36. Demerec, M. (1945a). Production of Staphylococcus strains resistant to various concentrations of penicillin. Proceedings of the National Academy of Sciences, USA, 31, 16-24.
37. Demerec M. Genetic aspects of changes in Staphylococcus aureus producing strains resistant to various concentrations of penicillin. Annals of the Missouri Botanical Garden 32 (1945) 131-138
38. Demerec M. Origin of bacterial resistance to antibiotics. Journal of Bacteriology 56 (1948) 63-74
39. Demerec M., and Fano U. Bacteriophage resistant mutants in Escherichia coli. Genetics 30 (1945) 119-136
40. D'Herelle, F. (1926). The bacteriophage and its behavior (G. H. Smith, Trans.). Baltimore, MD: Williams & Wilkins.
41. Dienert F. Sur la fermentation du galactose et sur l'accutoumance des levures à ce sucre. Annales de l'Institut Pasteur, Paris 14 (1900) 139-189
42. Dobzhansky, T. (1951). Genetics and the origin of species (3rd ed. rev.). New York: Columbia University Press.
43. Dowling H.F. Fighting infection: Conquests of the twentieth century (1977), Harvard University Press, Cambridge, MA
44. Dubos R.J. Microbiology. Annual Review of Biochemistry 11 (1942) 659-678
45. Dubos R.J. The bacterial cell in its relation to problems of virulence, immunity and chemotherapy (1945), Harvard University Press, Cambridge, MA
46. In: Dunn L.C. (Ed). Genetics in the twentieth century: Essays on the progress of genetics during its first 50 years (1951), Macmillan, New York
47. Eagle H. Drug resistance. Annals of the New York Academy of Sciences 59 (1954) 243-258
48. Eagle H. Challenging problems in antibiotic research. In: Waksman S.A. (Ed). Perspectives and horizons in microbiology (1955), Rutgers University Press, New Brunswick, NJ 168-178
49. Eagle H., and Saz A.K. Antibiotics. Annual Review of Microbiology 9 (1955) 173-226
50. Ehrlich, P. (1907). Chemotherapeutische Trypanosomen-Studien. Berliner klinische Wochenschrift, 44, 233-236, 280-283, 310-314, 341-344. (Reprinted in idem, Gesammelte Arbeiten, Vol. 3 (F. Himmelweit, Ed.) (pp. 81-105). London: Pergamon Press, 1957).
51. English A.R., and Gelwicks P.C. In vitro microbial resistance pattern to terramycin. Antibiotics & Chemotherapy 2 (1951) 118-124
52. Eriksen K.R. On the validity of the fluctuation test in studies on the mode of origin of penicillin resistant staphylococci. Acta Pathologica et Microbiologica Scandinavica 32 (1953) 393-401
53. Fildes P., and Whitaker K. 'Training' or mutation of bacteria. British Journal of Experimental Pathology 29 (1948) 240-248
54. Finland M. Emergence of antibiotic-resistant strains. New England Journal of Medicine 253 (1955) 909-922 969-979, 1019-1028
55. Fischer P., and Lipson C. Thinking about science: Max Delbrück and the origins of molecular biology (1988), W. W. Norton, New York
56. Gaudillière J.-P. J. Monod, S. Spiegelman et l'adaptation enzymatique. Programmes de recherche, cultures locales et traditions disciplinaires. History and Philosophy of the Life Sciences 14 (1992) 23-71
57. Gaudillière J.-P. Inventer la biomédecine: La France, l'Amérique et la production des savoirs du vivant (2002), Éditions la Découverte, Paris
58. Gould S.J. The hardening of the modern synthesis. In: Greene M. (Ed). Dimensions of Darwinism: Themes and counterthemes in twentieth century evolutionary theory (1983), Cambridge University Press, Cambridge 71-93
59. Gowen J.W. Mutation in Drosophila, bacteria and viruses. Cold Spring Harbor Symposia for Quantitative Biology 9 (1941) 187-192
60. Gradmann C. Isolation, contamination, and pure culture: Monomorphism and polymorphism of pathogenic micro-organisms as research problem, 1860-1880. Perspectives on Science 9 (2001) 147-172
61. Griffith F. The significance of Pneumococcal types. Journal of Hygeine 27 (1928) 113-159
62. Hadley P. Microbic dissociation: The instability of bacterial species with special reference to active dissociation and transmissible autolysis. Journal of Infectious Disease 40 (1927) 1-312
63. Haldane J.B.S. The Lysenko controversy. The Listener 40 9 December (1948) 875
64. Harwood J. The reception of Morgan's chromosome theory in Germany: Inter-war debate over cytoplasmic inheritance. Medizinhistorisches Journal 19 (1984) 3-32
65. Harwood J. Styles of scientific thought: The German genetics community, 1900-1933 (1993), University of Chicago Press, Chicago, IL
66. Hayes W. Recombination in Bact. coli K-12: Unidirectional transfer of genetic material. Nature 159 (1952) 118-119
67. Hinshelwood C.N. Bacterial growth. Biological Reviews 19 (1944) 150-163
68. Hinshelwood C.N. The chemical kinetics of the bacterial cell (1946), Clarendon Press, Oxford
69. Horsfall J.G., and Dimond A.E. Plant chemotherapy. Annual Review of Microbiology 5 (1951) 209-222
70. Hotchkiss R.D. Gene, transforming principle, and DNA. In: Cairns J., Stent G.S., and Watson J.D. (Eds). Phage and the origins of molecular biology (1966), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 180-200
71. Hughes S.S. Making dollars out of DNA: The first major patent in biotechnology and the commercialization of molecular biology, 1974-1980. Isis 92 (2001) 541-575
72. Huxley J.S. Evolution: The modern synthesis (1942), George Allen & Unwin, London
73. Jackson, D. A., Symons, R. H., & Berg, P. (1972). Biochemical method for inserting new genetic information into DNA of simian virus 40: Circular SV40 molecules containing lambda phage genes and the galactose operon of Escherichia coli. Proceedings of the National Academy of Sciences, USA, 69, 2904-2909.
74. Jacob F., and Monod J. Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology 3 (1961) 318-356
75. Jacob F., and Monod J. On the regulation of gene activity. Cold Spring Harbor Symposia on Quantitative Biology 26 (1961) 193-211
76. Jacob F., Perrin D., Sanchez C., and Monod J. L'opéron: Group de genes à expression coordonnée par un opérateur. Comptes Rendus de l'Académie des Sciences 250 (1960) 1727-1729
77. Karström H. Enzymatische Adaptation bei Mikroorganismen. Ergebnisse der Enzymforschung 7 (1937) 350-376
78. Kay L.E. Conceptual models and analytical tools: The biology of physicist Max Delbrück. Journal of the History of Biology 18 (1985) 207-246
79. Kay L.E. Selling pure science in wartime: The biochemical genetics of G.W. Beadle. Journal of the History of Biology 22 (1989) 73-101
80. Keller, E. F. (1992). Between language and science: The question of directed mutation in molecular genetics. In idem, Secrets of life, secrets of death: Essays on language, gender and science (pp. 161-178). New York: Routledge.
81. Kohler R.E. Innovation in normal science: Bacterial physiology. Isis 76 (1985) 162-181
82. Kohler R.E. Bacterial physiology: The medical context. Bulletin of the History of Medicine 59 (1985) 54-74
83. Krementsov N. A 'second front' in Soviet genetics: The international dimension of the Lysenko controversy, 1944-1947. Journal of the History of Biology 29 (1996) 229-250
84. Krementsov N. Stalinist science (1997), Princeton University Press, Princeton, NJ
85. Lederberg J. Gene recombination and linked segregations in Escherichia coli. Genetics 32 (1947) 505-525
86. Lederberg J. Bacterial variation. Annual Reviews of Microbiology 3 (1949) 1-22
87. Lederberg J. Inheritance, variation, and adaptation. In: Werkman C.H., and Wilson P.W. (Eds). Bacterial physiology (1951), Academic Press, New York 67-100
88. Lederberg J. Genetic studies with bacteria. In: Dunn L.C. (Ed). Genetics in the twentieth century: Essays on the progress of genetics during its first 50 years (1951), Macmillan, New York 263-289
89. Lederberg J. Cell genetics and hereditary symbiosis. Physiological Reviews 32 (1952) 403-430
90. Lederberg J. Replica plating and indirect selection of bacterial mutants: Isolation of preadaptive mutants in bacteria by sib selection. Genetics 121 (1989) 395-399
91. Lederberg J. Plasmid (1952-1997). Plasmid 39 (1998) 1-9
92. Lederberg J., and Lederberg E.M. Replica plating and indirect selection of bacterial mutants. Journal of Bacteriology 63 (1952) 399-406
93. Lederberg J., and Tatum E.L. Novel genotypes in mixed cultures of biochemical mutants of bacteria. Cold Spring Harbor Symposia on Quantitative Biology 11 (1946) 113-114
94. Lederberg J., and Tatum E.L. Gene recombination in Escherichia coli. Nature 158 (1947) 558
95. Lederberg J., and Zinder N. Concentration of biochemical mutants of bacteria with penicillin. Journal of the American Chemical Society 70 (1948) 4267-4268
96. Lepper M.H. Microbial resistance to antibiotics. Annals of Internal Medicine 43 (1955) 299-315
97. Lesch J. Chemistry and biomedicine in an industrial setting: The invention of sulfa drugs. In: Mauskopf S.H. (Ed). Chemical sciences in the modern world (1993), University of Pennsylvania Press, Philadelphia, PA 158-215
98. Lesch J. The discovery of M & B 693 (Sulfapyridine). In: Higby G.J., and Stroud E.C. (Eds). The inside story of medicines: A symposium (1997), American Institute of the History of Pharmacy, Madison, WI 101-119
99. Lindegren C. Mendelian and cytoplasmic inheritance in yeast. Annals of the Missouri Botanical Garden 32 (1945) 107-123
100. Luria S.E. Spontaneous bacterial mutations to resistance to antibacterial agents. Cold Spring Harbor Symposium on Quantitative Biology 11 (1946) 130-138
101. Luria S.E. Recent advances in bacterial genetics. Bacteriological Reviews 11 (1947) 1-40
102. Luria S.E. A slot machine, a broken test tube: An autobiography (1984), Harper & Row, New York
103. Luria S.E., and Delbrück M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28 (1943) 491-511
104. Maclean I.H., Rogers K.B., and Fleming A. M. & B. 693 and pneumococci. Lancet 1 (1939) 562-568
105. MacLeod, C.M., & Daddi, G. (1939). A 'sulfapyridine-fast' strain of pneumococcus type I. Proceedings of the Society for Experimental Biology and Medicine, 41, 69-71.
106. Mandel M., and Higa A. Calcium dependent bacteriophage DNA infection. Journal of Molecular Biology 53 (1970) 159-162
107. Maniatis T., Fritsch E.F., and Sambrook J. Molecular cloning: A laboratory manual (1982), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
108. Mazumdar P.H.M. Species and specificity: An interpretation of the history of immunology (1995), Cambridge University Press, Cambridge
109. Mendelsohn J.A. 'Like all that lives': Biology, medicine and bacteria in the age of Pasteur and Koch. History and Philosophy of the Life Sciences 24 (2002) 3-36
110. 1 restriction endonuclease generates cohesive ends. Proceedings of the National Academy of Sciences, USA, 69, 3370-3374.
111. Miller C.P., and Bohnhoff M. The development of bacterial resistance to chemotherapeutic agents. Annual Review of Microbiology 4 (1950) 201-222
112. Mitsuhashi S. Drug resistance in bacteria: history, genetics and biochemistry. The Journal of International Medical Research 21 (1993) 1-14
113. Moberg C.L. René Dubos, a harbinger of microbial resistance to antibiotics. Perspectives in Biology and Medicine 42 (1999) 559-580
114. Monod J. Remarks on the mechanism of enzyme induction. In: Gaebler O.H. (Ed). Enzymes: Units of biological structure and function (1956), Academic Press, New York 7-28
115. Morange M. A history of molecular biology (1998), Harvard University Press, Cambridge, MA
116. Morgan T.H. Genetics and the physiology of development. American Naturalist 60 (1926) 489-515
117. Morrow, J. F., Cohen, S. N., Chang, A. C. Y., Boyer, H. W., Goodman, H. M., & Helling, R. B. (1974). Replication and transcription of eukaryotic DNA in Escherichia coli. Proceedings of the National Academy of Sciences, USA, 71, 1743-1747.
118. Neushul P. Science, government, and the mass production of penicillin. Journal of the History of Medicine and Allied Sciences 48 (1993) 371-395
119. Neushul, P. (1998). Fighting research: Army participation in the clinical testing and mass productin of penicillin during the Second World War. In R. Cooter, M. Harrison, & S. Study (Eds.), War, medicine and modernity (pp. 203-224).
120. North E.A., and Christie R. Observations on the sensitivity of Staphylococci to penicillin. Medical Journal of Australia 2 (1945) 44-46
121. Novick R.P. Analysis of transduction of mutations affecting penicillinase formation in Staphylococcus aureus. Journal of General Microbiology 33 (1963) 121-136
122. Oakberg E.F., and Luria S.E. Mutations to sulfonamide resistance in Staphylococcus aureus. Genetics 32 (1947) 249-261
123. Plumb, R. K. (1954). Lysenko theory facing new test. New York Times, 10 June, 33.
124. Plumb, R. K. (1955). War on bacteria seen backfiring. New York Times, 10 May, 25.
125. Plumb, R. K. (1957). Hospitals found in germ danger. New York Times, 17 October, 35.
126. Portugal F.H., and Cohen J.S. A century of DNA: A history of the discovery of the structure and function of the genetic substance (1977), MIT Press, Cambridge, MA
127. Rammelkamp, C. H., & Maxon, T. (1942). Resistance of Staphylococcus aureus to the action of penicillin. Proceedings of the Society for Experimental Biology and Medicine, 51, 386-389.
128. Reedy R.J. Review of Drug resistance in microorganisms: Mechanisms of development. Antibiotics & Chemotherapy 9 (1959) 247
129. Rheinberger H.-J. Beyond nature and culture: A note on medicine in the age of molecular biology. Science in Context 8 (1995) 249-263
130. Rheinberger H.-J. Toward a history of epistemic things: Synthesizing proteins in the test tube (1997), Stanford University Press, Stanford, CA
131. Richards A.N. Production of penicillin in the United States (1941-1946). Nature 201 (1964) 441-445
132. Roland F., and Stuart C.A. 'Directed mutation' toward streptomycin resistance in Salmonella typhi. Antibiotics & Chemotherapy 1 (1951) 523-529
133. Roll-Hansen N. The Lysenko effect: The politics of science (2005), Humanity Books, Amherst, NY
134. Rosenkrantz, B. G. (1995). Historical review: Responses to antibiotic resistance. In US Congress, Office of Technology Assessment, Impacts of Antibiotic-Resistant Bacteria, OTA-H-629 (Appendix A, 'coverage of antibiotic resistance in the popular literature, 1950 to 1994, pp. 167-172). Washington, DC: US Government Printing Office.
135. Rossianov K.O. Editing nature: Joseph Stalin and the 'new' Soviet biology. Isis 84 (1993) 728-745
136. Ryan F. Back-mutation and adaptation of nutritional mutants. Cold Spring Harbor Symposia for Quantitative Biology 11 (1946) 215-227
137. Ryan, F., & Lederberg, J. (1946). Reverse-mutation and adaptation in leucineless Neurospora. Proceedings of the National Academy of Sciences, USA, 32, 163-173.
138. Ryan, F. J., Schneider, L. K., & Ballantine, R. (1946). Mutations involving the requirement of uracil in Clostridium. Proceedings of the National Academy of Sciences, USA, 32, 261-271.
139. Sankaran, N. (2006). Frank Macfarlane Burnet and the nature of bacteriophage, 1924-1937. Ph.D. thesis, Yale University.
140. Sapp J. Beyond the gene: Cytoplasmic inheritance and the struggle for authority in genetics (1987), Oxford University Press, New York & Oxford
141. Sapp J. Evolution by association: A history of symbiosis (1994), Oxford University Press, New York & Oxford
142. Sapp J. Genesis: The evolution of biology (2003), Oxford University Press, Oxford & New York
143. Sapp, J. (2005). The bacterium's place in nature. In idem (Ed.), Microbial phylogeny and evolution: Concepts and controversies (pp. 1-52). Oxford & New York: Oxford University Press.
144. Schatz, A., Bugie, E., & Waksman, S. A. (1944). Streptomycin, a substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria. Proceedings of the Society for Experimental Biology and Medicine, 55, 66-69.
145. Selya, R.E. (2002). Salvador Luria's unfinished experiment: The public life of a biologist in a Cold War democracy. Ph.D. thesis, Harvard University.
146. Sgaramella, V. (1972). Enzymatic oligomerization of bacteriophage P22 DNA and of linear simian virus 40 DNA. Proceedings of the National Academy of Sciences, USA, 69, 3389-3393.
147. Smith D.H. R factors mediate resistance to mercury, nickel, and cobalt. Science 156 (1967) 1114-1116
148. Smocovitis V.B. Unifying biology: The evolutionary synthesis and evolutionary biology (1996), Princeton University Press, Princeton, NJ
149. Sonneborn T.M. Heredity, environment, and politics. Science 111 (1950) 529-539
150. Soyfer, V. N. (1994). Lysenko and the tragedy of Soviet science (L. Gruliow & R. Gruliow, Trans.). New Brunswick, NJ: Rutgers University Press.
151. Spath, S. B. (1999). C.B. van Niel and the culture of microbiology, 1920-1965. Ph.D. thesis, University of California, Berkeley.
152. Spiegelman S., and Kamen M.D. Genes and nucleoproteins in the synthesis of enzymes. Science 104 (1946) 581-584
153. Steffee C.H. Penicillins and Staphylococci: A historical interaction. Perspectives in Biology and Medicine 35 (1992) 596-608
154. Stephenson M. The economy of the bacterial cell. In: Needham J., and Green D.E. (Eds). Perspectives in biochemistry (1937), Cambridge University Press, Cambridge 91-98
155. Stephenson M., and Stickland L.H. Hydrogenylases. Further experiments on the formation of formic hydrogenylase by Bact. coli. Biochemical Journal 27 (1933) 1528-1532
156. Stephenson M., and Yudkin J. Galactozymase considered as an adaptive enzyme. Biochemical Journal 30 (1936) 506-514
157. Summers W.C. From culture as organism to organism as cell: Historical origins of bacterial genetics. Journal of the History of Biology 24 (1991) 171-190
158. Summers W.C. How bacteriophage came to be used by the Phage Group. Journal of the History of Biology 26 (1993) 255-267
159. Summers W.C. A historical introduction. In: Lewis K., Salyers A.A., Taber H.W., and Wax R.G. (Eds). Bacterial resistance to antimicrobials (2002), Marcel Dekker, New York xvii-xxiii
160. Summers W.C. From enzyme adaptation to gene regulation. Advances in Applied Microbiology 52 (2003) 159-166
161. Szybalski W. 'Natural' and 'artificial' penicillin resistance in Staphylococcus (Micrococcus pyogenes var. aureus). Antibiotics & Chemotherapy 3 (1953) 915-919
162. Tatum E.L., and Lederberg J. Gene recombination in the bacterium Escherichia coli. Journal of Bacteriology 53 (1947) 673-684
163. Thornley M.J., Sinai J., and Yudkin J. Multiple mechanisms of acquired drug resistance. In: Wolstenholme G.E.W., and O'Connor C.M. (Eds). Ciba Foundation symposium on drug resistance in micro-organisms: Mechanisms of development (1957), Little, Brown & Company, Boston, MA 141-160
164. Vernon K. Pus, sewage, beer and milk: Microbiology in Britain, 1870-1940. History of Science 28 (1990) 289-325
165. Wainwright M. Streptomycin: Discovery and resultant controversy. History and Philosophy of the Life Sciences 13 (1991) 97-124
166. Waisbren B.A., Carr C., and Struxness D. Role of inhibitors and mutations in antibiotic resistance by Escherichia coli. Antibiotics & Chemotherapy 1 (1951) 535-539
167. Waksman S.A. Definition of antibiotics. Antibiotics & Chemotherapy 6 (1956) 90-94
168. Watanabe T. Infective heredity of multiple drug resistance in bacteria. Bacteriological Reviews 27 (1963) 87-115
169. Watson J.D., and Tooze J. The DNA story: A documentary history of gene cloning (1981), W. H. Freeman, San Francisco, CA
170. Wilson G.S., and Miles A.A. Topley and Wilson's principles of bacteriology and immunology. 4th ed. (1955), Williams & Wilkins, Baltimore, MD
171. Winkler H. Über die Rolle von Kern und Protoplasma bei der Vererbung. Zeitschrift für Induktive Abstammungs- und Vererbungslehre 33 (1924) 238-253
172. Witkin, E. (1946). Inherited differences in sensitivity to radiation in Escherichia coli. Proceedings of the National Academy of Sciences, USA, 32, 59-68.
173. In: Wolstenholme G.E.W., and O'Connor C.M. (Eds). Ciba Foundation symposium on drug resistance in micro-organisms: Mechanisms of development (1957), Little, Brown & Company, Boston, MA
174. Wright S. The physiology of the gene. Physiological Reviews 21 (1941) 487-527
175. Wright S. Molecular politics: Developing American and British regulatory policy for genetic engineering, 1971-1982 (1994), University of Chicago Press, Chicago, IL
176. Wyatt H.V. When does information become knowledge?. Nature 235 (1972) 86-89
177. Yudkin J. Hydrogenlyases. II. Some factors concerned in the production of the enzymes. Biochemical Journal 36 (1932) 1859-1871
178. Yudkin J. Enzyme variation in micro-organisms. Biological Reviews 13 (1938) 93-106
179. Yudkin J. Origin of acquired drug resistance in bacteria. Nature 171 (1953) 541-546