Terbinafine quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: Application to a bioequivalence study

Therapeutic Drug Monitoring

Volumn 23, Issue 6, 2001, Pages 709-716

  De Oliveira, C H ^a   Barrientos Astigarraga, R E ^a   De Moraes, M O ^a   Bezerra, F A F ^a   De Moraes, M E A ^a   De Nucci, G ^a  

^a NONE   (Brazil)

Author keywords

HPLC; Lamisil; LC MS MS; Naftifine; Terbinafine

Indexed keywords

NAFTIFINE; TERBINAFINE;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TABLET FORMULATION;

ANTIFUNGAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; NAPHTHALENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERAPEUTIC EQUIVALENCY;

EID: 0035191947     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200112000-00019     Document Type: Article

References (12)

1. Antifungal agents: Mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
2. Terbinafine: Mode of action and properties of the squalene epoxidase inhibition
3. Simultaneous determination of terbinafine (Lamisil®) and five metabolites in human plasma and urine by high-performance liquid chromatography using online solid-phase extraction
4. Determination of terbinafine and its desmethyl metabolite in human plasma by high-performance liquid chromatography
5. Determination of terbinafine in nail samples during systemic treatment for onychomycoses
6. An investigation of the pharmacokinetics of topical terbinafine (Lamisil®) 1% cream
7. Determination of terbinafine (Lamisil®) in human hair by microbore liquid chromatography / tandem mass spectrometry
8. Quantitative analysis of terbinafine (Lamisil®) in human and minipig plasma by liquid chromatography tandem mass spectrometry
9. Hepatitis associated with terbinafine therapy: Three case reports and a review of the literature
10. Dose-proportional pharmacokinetics of terbinafine and its N-demethylated metabolite in healthy volunteers
11. In vivo bioequivalence guidances
12. Bioavailability and bioequivalence requirements abbreviated applications; proposed revisions - FDA. Proposed rule