Human mature erythroblasts are resistant to apoptosis

Experimental Cell Research

Volumn 313, Issue 5, 2007, Pages 1024-1032

  Hristoskova, Sashka ^a   Holzgreve, Wolfgang ^a   Hahn, Sinuhe ^a   Rusterholz, Corinne ^a  

^a UNIVERSITY WOMEN S HOSPITAL   (Switzerland)

Author keywords

Apoptosis; Caspase activation; Cell differentiation; Cytochrome c; Human erythroblast

Indexed keywords

CASPASE; CYTOCHROME C; CYTOKINE; DNA FRAGMENT;

APOPTOSIS; ARTICLE; CELL FATE; CELL MATURATION; CELL SURVIVAL; CYTOSOL; ENZYME ACTIVATION; ENZYME SYNTHESIS; ERYTHROBLAST; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; STEM CELL;

EID: 33847054781     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2006.12.018     Document Type: Article

References (32)

1. Koury M.J., Sawyer S.T., and Brandt S.J. New insights into erythropoiesis. Curr. Opin. Hematol. 9 (2002) 93-100
2. Gregory C.J., and Eaves A.C. Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties. Blood 51 (1978) 527-537
3. Koury S.T., Koury M.J., and Bondurant M.C. Morphological changes in erythroblasts during erythropoietin-induced terminal differentiation in vitro. Exp. Hematol. 16 (1988) 758-763
4. Danial N.N., and Korsmeyer S.J. Cell death: critical control points. Cell 116 (2004) 205-219
5. Testa U. Apoptotic mechanisms in the control of erythropoiesis. Leukemia 18 (2004) 1176-1199
6. De Maria R., Testa U., Luchetti L., Zeuner A., Stassi G., Pelosi E., Riccioni R., Felli N., Samoggia P., and Peschle C. Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood 93 (1999) 796-803
7. Zamai L., Secchiero P., Pierpaoli S., Bassini A., Papa S., Alnemri E.S., Guidotti L., Vitale M., and Zauli G. TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis. Blood 95 (2000) 3716-3724
8. Dai C.H., Price J.O., Brunner T., and Krantz S.B. Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood 91 (1998) 1235-1242
9. Liu Y., Pop R., Sadegh C., Brugnara C., Haase V.H., and Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood 108 (2006) 123-133
10. De Maria R., Zeuner A., Eramo A., Domenichelli C., Bonci D., Grignani F., Srinivasula S.M., Alnemri E.S., Testa U., and Peschle C. Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature 401 (1999) 489-493
11. Zeuner A., Eramo A., Testa U., Felli N., Pelosi E., Mariani G., Srinivasula S.M., Alnemri E.S., Condorelli G., Peschle C., and De Maria R. Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1. Cell Death Differ. 10 (2003) 905-913
12. Zermati Y., Garrido C., Amsellem S., Fishelson S., Bouscary D., Valensi F., Varet B., Solary E., and Hermine O. Caspase activation is required for terminal erythroid differentiation. J. Exp. Med. 193 (2001) 247-254
13. Launay S., Hermine O., Fontenay M., Kroemer G., Solary E., and Garrido C. Vital functions for lethal caspases. Oncogene 24 (2005) 5137-5148
14. Morioka K., Tone S., Mukaida M., and Takano-Ohmuro H. The apoptotic and nonapoptotic nature of the terminal differentiation of erythroid cells. Exp. Cell Res. 240 (1998) 206-217
15. Carlile G.W., Smith D.H., and Wiedmann M. Caspase-3 has a nonapoptotic function in erythroid maturation. Blood 103 (2004) 4310-4316
16. Rubiolo C., Piazzolla D., Meissl K., Beug H., Huber J.C., Kolbus A., and Baccarini M. A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. Blood 108 (2006) 152-159
17. Hristoskova S., Holzgreve W., and Hahn S. More than one-half of the erythroblasts in the fetal circulation and cord blood are TUNEL positive. Clin. Chem. 47 (2001) 1870-1871
18. Hristoskova S., Holzgreve W., and Hahn S. Fetal nucleated erythrocytes in maternal circulation do not display a classic membrane-associated apoptotic characteristic (phosphatidylserine exposure) despite being positive by terminal dUTP nuclear end labeling. Clin. Chem. 49 (2003) 1934-1937
19. Zermati Y., Fichelson S., Valensi F., Freyssinier J.M., Rouyer-Fessard P., Cramer E., Guichard J., Varet B., and Hermine O. Transforming growth factor inhibits erythropoiesis by blocking proliferation and accelerating differentiation of erythroid progenitors. Exp. Hematol. 28 (2000) 885-894
20. Berg C.P., Engels I.H., Rothbart A., Lauber K., Renz A., Schlosser S.F., Schulze-Osthoff K., and Wesselborg S. Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis. Cell Death Differ. 8 (2001) 1197-1206
21. Bratosin D., Estaquier J., Petit F., Arnoult D., Quatannens B., Tissier J.P., Slomianny C., Sartiaux C., Alonso C., Huart J.J., Montreuil J., and Ameisen J.C. Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria. Cell Death Differ. 8 (2001) 1143-1156
22. Kolbus A., Pilat S., Husak Z., Deiner E.M., Stengl G., Beug H., and Baccarini M. Raf-1 antagonizes erythroid differentiation by restraining caspase activation. J. Exp. Med. 196 (2002) 1347-1353
23. Weil M., Raff M.C., and Braga V.M. Caspase activation in the terminal differentiation of human epidermal keratinocytes. Curr. Biol. 9 (1999) 361-364
24. Ishizaki Y., Jacobson M.D., and Raff M.C. A role for caspases in lens fiber differentiation. J. Cell Biol. 140 (1998) 153-158
25. Zeuner A., Pedini F., Signore M., Testa U., Pelosi E., Peschle C., and De Maria R. Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins. Blood 102 (2003) 87-93
26. Motoyama N., Kimura T., Takahashi T., Watanabe T., and Nakano T. Bcl-X prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation. J. Exp. Med. 189 (1999) 1691-1698
27. Josefsen D., Myklebust J.H., Lomo J., Sioud M., Blomhoff H.K., and Smeland E.B. Differential expression of bcl-2 homologs in human CD34(+) hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells. Stem Cells 18 (2000) 261-272
28. Rhodes M.M., Kopsombut P., Bondurant M.C., Price J.O., and Koury M.J. Bcl-X(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. Blood 106 (2005) 1857-1863
29. Spierings D., McStay G., Saleh M., Bender C., Chipuk J., Maurer U., and Green D.R. Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 310 (2005) 66-67
30. Vaux D.L., and Silke J. IAPs, RINGs and ubiquitylation. Nat. Rev., Mol. Cell Biol. 6 (2005) 287-297
31. Chu Z.L., Pio F., Xie Z., Welsh K., Krajewska M., Krajewski S., Godzik A., and Reed J.C. A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J. Biol. Chem. 276 (2001) 9239-9245
32. Silke J., Kratina T., Chu D., Ekert P.G., Day C.L., Pakusch M., Huang D.C., and Vaux D.L. Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16182-16187