Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes

Veterinary Parasitology

Volumn 144, Issue 3-4, 2007, Pages 313-320

  Ghisi, Marc ^a,b   Kaminsky, Ronald ^b   Mäser, Pascal ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Novartis Centre de Recherche Santé Animale   (Switzerland)

Author keywords

Benzimidazole; Drug resistance; Haemonchus contortus; Point mutation; Tubulin

Indexed keywords

ALANINE; ALBENDAZOLE; BENOMYL; BENZIMIDAZOLE; BETA TUBULIN; ENDEX; FENBENDAZOLE; GENOMIC DNA; GLUTAMIC ACID; IVERMECTIN; LEVAMISOLE; MOXIDECTIN; TIABENDAZOLE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; AUSTRALIA; DNA SEQUENCE; DRUG SENSITIVITY; EGG; FUNGAL STRAIN; GENE AMPLIFICATION; GENE SEQUENCE; GENOTYPE PHENOTYPE CORRELATION; HAEMONCHUS CONTORTUS; HATCHING; MOLECULAR CLONING; MONILINIA FRUCTICOLA; MULTIDRUG RESISTANCE; NEMATODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PARASITOSIS; POINT MUTATION; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SHEEP; SOUTH AFRICA;

FUNGI; HAEMONCHUS CONTORTUS; MONILINIA FRUCTICOLA; NEMATODA; OVIS ARIES;

EID: 33847053644     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2006.10.003     Document Type: Article

References (32)

1. Altschul S.F., Gish W., Miller W., Myers E.W., and Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215 (1990) 403-410
2. Alvarez-Sanchez M.A., Perez-Garcia J., Cruz-Rojo M.A., and Rojo-Vazquez F.A. Real time PCR for the diagnosis of benzimidazole resistance in trichostrongylids of sheep. Vet. Parasitol. 129 (2005) 291-298
3. Brown H.D., Matzuk A.R., Ilves I.R., Peterson L.H., Harris S.A., Sarett L.H., Egerton J.R., Yakstis J.J., Campbell W.C., and Cuckler A.C. Antiparasitic drugs. IV. 2-(4′-Thiazolyl)-benzimidazole, a new anthelmintic. J. Am. Chem. Soc. 83 (1961) 1764-1765
4. Chabala J.C., Mrozik H., Tolman R.L., Eskola P., Lusi A., Peterson L.H., Woods M.F., Fisher M.H., Campbell W.C., Egerton J.R., and Ostlind D.A. Ivermectin, a new broad-spectrum antiparasitic agent. J. Med. Chem. 23 (1980) 1134-1136
5. Coles G.C., Bauer C., Borgsteede F.H., Geerts S., Klei T.R., Taylor M.A., and Waller P.J. World Association For The Advancement Of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol. 44 (1992) 35-44
6. Drogemuller M., Schnieder T., and von Samson-Himmelstjerna G. Beta-tubulin complementary DNA sequence variations observed between cyathostomins from benzimidazole-susceptible and -resistant populations. J. Parasitol. 90 (2004) 868-870
7. Elard L., Cabaret J., and Humbert J.F. PCR diagnosis of benzimidazole-susceptibility or -resistance in natural populations of the small ruminant parasite, Teladorsagia circumcincta. Vet. Parasitol. 80 (1999) 231-237
8. Elard L., and Humbert J.F. Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole resistance of the small-ruminant parasite, Teladorsagia circumcincta. Parasitol. Res. 85 (1999) 452-456
9. Fujimura M., Oeda K., Inoue H., and Kato T. A single amino-acid substitution in the beta-tubulin gene of neurospora confers both carbendazim resistance and diethofencarb sensitivity. Curr. Genet. 21 (1992) 399-404
10. Jung M.K., Wilder I.B., and Oakley B.R. Amino acid alterations in the benA (beta-tubulin) gene of Aspergillus nidulans that confer benomyl resistance. Cell. Motil. Cytoskeleton 22 (1992) 170-174
11. Kaminsky R. Drug resistance in nematodes: a paper tiger or a real problem?. Curr. Opin. Infect. Dis. 16 (2003) 559-564
12. Kaplan R.M. Drug resistance in nematodes of veterinary importance: a status report. Trends Parasitol. 20 (2004) 477-481
13. Kwa M.S., Veenstra J.G., and Roos M.H. Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta-tubulin isotype 1. Mol. Biochem. Parasitol. 63 (1994) 299-303
14. Kwa M.S., Veenstra J.G., Van Dijk M., and Roos M.H. Beta-tubulin genes from the parasitic nematode Haemonchus contortus modulate drug resistance in Caenorhabditis elegans. J. Mol. Biol. 246 (1995) 500-510
15. Ma Z., Yoshimura M.A., and Michailides T.J. Identification and characterization of benzimidazole resistance in Monilinia fructicola from stone fruit orchards in California. Appl. Environ. Microbiol. 69 (2003) 7145-7152
16. McKay G.J., and Cooke L.R. A PCR-based method to characterise and identify benzimidazole resistance in Helminthosporium solani. FEMS Microbiol. Lett. 152 (1997) 371-378
17. Njue A.I., and Prichard R.K. Cloning two full-length beta-tubulin isotype cDNAs from Cooperia oncophora, and screening for benzimidazole resistance-associated mutations in two isolates. Parasitology 127 (2003) 579-588
18. Oxberry M.E., Gear T.G., and Prichard R.K. Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus. Parasitology 122 (2001) 683-687
19. Page R.D. TreeView: an application to display phylogenetic trees on personal computers. Comput. Appl. Biosci. 12 (1996) 357-358
20. Park S.Y., Jung O.J., Chung Y.R., and Lee C.W. Isolation and characterization of a benomyl-resistant form of beta-tubulin-encoding gene from the phytopathogenic fungus Botryotinia fuckeliana. Mol. Cells 7 (1997) 104-109
21. Prichard R. Genetic variability following selection of Haemonchus contortus with anthelmintics. Trends Parasitol. 17 (2001) 445-453
22. Robinson M., Trudgett A., Fairweather I., and McFerran N. Benzimidazole binding to Haemonchus contortus tubulin: a question of structure. Trends Parasitol. 18 (2002) 153-154 author reply 154
23. Robinson M.W., McFerran N., Trudgett A., Hoey L., and Fairweather I. A possible model of benzimidazole binding to beta-tubulin disclosed by invoking an inter-domain movement. J. Mol. Graph. Model 23 (2004) 275-284
24. Silvestre A., and Cabaret J. Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?. Mol. Biochem. Parasitol. 120 (2002) 297-300
25. Smith J.M., and Prichard R.K. Localization of P-glycoprotein mRNA in the tissues of Haemonchus contortus adult worms and its relative abundance in drug-selected and susceptible strains. J. Parasitol. 88 (2002) 612-620
26. Thompson J.D., Higgins D.G., and Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic. Acids Res. 22 (1994) 4673-4680
27. Tiwari J., Kumar S., Kolte A.P., Swarnkar C.P., Singh D., and Pathak K.M. Detection of benzimidazole resistance in Haemonchus contortus using RFLP-PCR technique. Vet. Parasitol. 138 (2006) 301-307
28. van Wyk J.A., and Malan F.S. Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa. Vet. Rec. 123 (1988) 226-228
29. van Wyk J.A., Malan F.S., and Randles J.L. How long before resistance makes it impossible to control some field isolates of Haemonchus contortus in South Africa with any of the modern anthelmintics?. Vet. Parasitol. 70 (1997) 111-122
30. Varady M., and Corba J. Comparison of six in vitro tests in determining benzimidazole and levamisole resistance in Haemonchus contortus and Ostertagia circumcincta of sheep. Vet. Parasitol. 80 (1999) 239-249
31. von Samson-Himmelstjerna G., Harder A., Pape M., and Schnieder T. Novel small strongyle (Cyathostominae) beta-tubulin sequences. Parasitol. Res. 87 (2001) 122-125
32. Wolstenholme A.J., Fairweather I., Prichard R., von Samson-Himmelstjerna G., and Sangster N.C. Drug resistance in veterinary helminths. Trends Parasitol. 20 (2004) 469-476