Tgat, a Rho-specific guanine nucleotide exchange factor, activates NF-κB via physical association with IκB kinase complexes

Biochemical and Biophysical Research Communications

Volumn 355, Issue 1, 2007, Pages 269-274

  Yamada, Kenji ^a   Moriuchi, Ryozo ^a   Mori, Tsuyoshi ^a   Okazaki, Eiko ^a   Kohno, Tomoko ^a   Nagayasu, Takeshi ^a   Matsuyama, Toshifumi ^a   Katamine, Shigeru ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

ATL; HTLV 1; NF B; Rho GTPase; Tax; Tgat; Trio

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P52; RHO FACTOR; TGAT PROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; DNA LIBRARY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; T CELL LEUKEMIA;

CELL LINE; DNA, COMPLEMENTARY; GENES, REPORTER; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; I-KAPPA B KINASE; KIDNEY; KINETICS; NF-KAPPA B; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; TRANSFECTION;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 33847045144     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.01.147     Document Type: Article

References (21)

1. Mosialos G. The role of Rel/NF-kappa B proteins in viral oncogenesis and the regulation of viral transcription. Semin. Cancer Biol. 8 (1997) 121-129
2. Saito N., Courtois G., Chiba A., Yamamoto N., Nitta T., Hironaka N., Rowe M., and Yamaoka S. Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines. J. Biol. Chem. 278 (2003) 46565-46575
3. Dadke D., Fryer B., Golemis E., and Field J. Activation of p21-activated kinase 1-nuclear factor kappaB signaling by Kaposi's sarcoma-associated herpes virus G protein-coupled receptor during cellular transformation. Cancer Res. 63 (2003) 8837-8847
4. Kwok R., Laurance M., Lundblad J., Goldman P., Shih H., Connor L., Marriott S., and Goodman R. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature 380 (1996) 642-646
5. Yamaoka S., Inoue H., Sakurai M., Sugiyama T., Hazama M., Yamada T., and Hatanaka M. Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J. 15 (1996) 873-887
6. Furukawa Y., Kubota R., Tara M., Izumo S., and Osame M. Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood 97 (2001) 987-993
7. Okazaki S., Moriuchi R., Yosizuka N., Sugahara K., Maeda T., Jinnai I., Tomonaga M., Kamihira S., and Katamine S. HTLV-1 proviruses encoding non-functional TAX in adult T-cell leukemia. Virus Genes 23 (2001) 123-135
8. Takeda S., Maeda M., Morikawa S., Taniguchi Y., Yasunaga J., Nosaka K., Tanaka Y., and Matsuoka M. Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int. J. Cancer 109 (2004) 559-567
9. Mori N., Fujii M., Ikeda S., Yamada Y., Tomonaga M., Ballard D.W., and Yamamoto N. Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood 93 (1999) 2360-2368
10. Yoshizuka N., Moriuchi R., Mori T., Yamada K., Hasegawa S., Maeda T., Shimada T., Yamada Y., Kamihira S., Tomonaga M., and Katamine S. An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential. J. Biol. Chem. 279 (2004) 43998-44004
11. Hironaka N., Mochida K., Mori N., Maeda M., Yamamoto N., and Yamaoka S. Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia 6 (2004) 266-278
12. Hirai H., Fujisawa J., Suzuki T., Ueda K., Muramatsu M., Tsuboi A., Arai N., and Yoshida M. Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105. Oncogene 7 (1992) 1737-1742
13. Lanoix J., Lacoste J., Pepin N., Rice N., and Hiscott J. Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway. Oncogene 9 (1994) 841-852
14. Murakami T., Hirai H., Suzuki T., Fujisawa J., and Yoshida M. HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100. Virology 206 (1995) 1066-1074
15. Petropoulos L., and Hiscott J. Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state. Virology 252 (1998) 189-199
16. Chu Z., DiDonato J., Hawiger J., and Ballard D. The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. J. Biol. Chem. 273 (1998) 15891-15894
17. Geleziunas R., Ferrell S., Lin X., Mu Y., Cunningham E.J., Grant M., Connelly M., Hambor J., Marcu K., and Greene W. Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. Mol. Cell. Biol. 18 (1998) 5157-5165
18. Uhlik M., Good L., Xiao G., Harhaj E.W., Zandi E., Karin M., and Sun S.C. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J. Biol. Chem. 273 (1998) 21132-21136
19. Yin M., Christerson L., Yamamoto Y., Kwak Y., Xu S., Mercurio F., Barbosa M., Cobb M., and Gaynor R. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell 93 (1998) 875-884
20. O'Mahony A.M., Montano M., Van Beneden K., Chen L.F., and Greene W.C. Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65. J. Biol. Chem. 279 (2004) 18137-18145
21. Xiao G., Cvijic M.E., Fong A., Harhaj E.W., Uhlik M.T., Waterfield M., and Sun S.C. Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J. 20 (2001) 6805-6815