Bone morphogenetic protein and retinoic acid-inducible neural specific protein-3 is expressed in gonadotrope cell pituitary adenomas and induces proliferation, migration, and invasion

Endocrinology

Volumn 148, Issue 3, 2007, Pages 967-975

  Shorts Cary, Lynnette ^a,c   Xu, Mei ^a,c   Ertel, Jessica ^a,c   Kleinschmidt Demasters, B K ^a   Lillehei, Kevin ^b   Matsuoka, Ichiro ^d   Nielsen Preiss, Sheila ^a,c   Wierman, Margaret E ^a,c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; MESSENGER RNA; PROCOLLAGEN C PROTEINASE; PROTEIN; PROTEIN ANTIBODY; RETINOIC ACID INDUCIBLE NEURAL SPECIFIC PROTEIN 3; RETINOIC ACID INDUCIBLE NEURAL SPECIFIC PROTEIN 3 ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GONADOTROPH ADENOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ADENOMA; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; GONADOTROPHS; HUMANS; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; PITUITARY NEOPLASMS; TRETINOIN;

EID: 33847034187     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0905     Document Type: Article

References (28)

1. Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, McCutcheon IE 2004 The prevalence of pituitary adenomas: a systematic review. Cancer 101:613-619
2. Melmed S 2003 Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112:1603-1618
3. Jameson JL, Klibanski A, Black PM, Zervas NT, Lindell CM, Hsu DW, Ridgway EC, Habener JF 1987 Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest 80:1472-1478
4. Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A, Klibanski A 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest 86:336-340
5. Ridgway EC, Klibanski A, Ladenson PW, Clemmons D, Beitins IZ, McArthur JW, Martorana MA, Zervas NT 1981 Pure α-secreting pituitary adenomas. N Engl J Med 304:1254-1259
6. Oppenheim DS, Klibanski A 1989 Medical therapy of glycoprotein hormone-secreting pituitary tumors. Endocrinol Metab Clin North Am 18:339-358
7. Ezzat S 2003 Pituitary tumor pathogenesis - the hunt for novel candidate genes continues. J Clin Endocrinol Metab 88:5116-5118
8. Evans CO, Young AN, Brown MR, Brat DJ, Parks JS, Neish AS, Oyesiku NM 2001 Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. J Clin Endocrinol Metab 86:3097-3107
9. Evans CO, Reddy P, Brat DJ, O'Neill EB, Craige B, Stevens VL, Oyesiku NM 2003 Differential expression of folate receptor in pituitary adenomas. Cancer Res 63:4218-4224
10. Zhang X, Sun H, Danila DC, Johnson SR, Zhou Y, Swearingen B, Klibanski A 2002 Loss of expression of GADD45γ, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. J Clin Endocrinol Metab 87:1262-1267
11. Zhang X, Zhou Y, Mehta KR, Danila DC, Scolavino S, Johnson SR, Klibanski A 2003 A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab 88:5119-5126
12. Zhao J, Dahle D, Zhou Y, Zhang X, Klibanski A 2005 Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. J Clin Endocrinol Metab 90:2179-2186
13. Wang Z, Melmed S 2000 Pituitary tumor transforming gene (PTTG) transforming and transactivation activity. J Biol Chem 275:7459-7461
14. Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S 1999 Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 84:761-767
15. Pei L, Melmed S 1997 Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11:433-441
16. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S 1999 Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 5:1317-1321
17. Ezzat S, Zheng L, Zhu XF, Wu GE, Asa SL 2002 Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. J Clin Invest 109:69-78
18. Ezzat S, Zheng L, Asa SL 2004 Pituitary tumor-derived fibroblast growth factor receptor 4 isoform disrupts neural cell-adhesion molecule/N-cadherin signaling to diminish cell adhesiveness: a mechanism underlying pituitary neoplasia. Mol Endocrinol 18:2543-2552
19. Habuchi T, Luscombe M, Elder PA, Knowles MA 1998 Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. Genomics 48:277-288
20. Allen MP, Linseman DA, Udo H, Xu M, Schaack JB, Varnum B, Kandel ER, Heidenreich KA, Wierman ME 2002 Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase. Mol Cell Biol 22:599-613
21. Kawano H, Nakatani T, Mori T, Ueno S, Fukaya M, Abe A, Kobayashi M, Toda F, Watanabe M, Matsuoka I 2004 Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. Brain Res Mol Brain Res 125:60-75
22. Nakatani T, and Matsuoka I 2004 Molecular mechanisms regulating cell type specific expression of BMP/RA inducible neural-specific protein-1 that suppresses cell cycle progression: roles of NRSF/REST and DNA methylation. Brain Res Mol Brain Res 125:47-59
23. Kobayashi I, Jin L, Ruebel KH, Bayliss JM, Hidehiro O, Lloyd RV 2003 Regulation of cell growth and expression of 7B2, PC2, and PC1/3 by TGFβ 1 and sodium butyrate in a human pituitary cell line (HP75). Endocrine 22:285-292
24. Horiguchi H, Jin L, Ruebel KH, Scheithauer BW, Lloyd RV 2004 Regulation of VEGF-A, VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line (HP75) by TGFβ1, bFGF, and EGF. Endocrine 24:141-146
25. Mellon PL, Windle JJ, Weiner RI 1991 Immortalization of neuroendocrine cells by targeted oncogenesis. Recent Prog Horm Res 47:69-93; discussion 93-96
26. Akerblom IE, Ridgway EC, Mellon PL 1990 An α-subunit- secreting cell line derived from a mouse thyrotrope tumor. Mol Endocrinol 4:589-596
27. Scully KM, Rosenfeld MG 2002 Pituitary development: regulatory codes in mammalian organogenesis. Science 295:2231-2235
28. Sheng HZ, Westphal H 1999 Early steps in pituitary organogenesis. Trends Genet 15:236-240