A bioreversible prodrug approach designed to shift mechanism of brain uptake for amino-acid-containing anticancer agents

Journal of Neurochemistry

Volumn 76, Issue 4, 2001, Pages 966-974

  Killian, Dennis M ^a   Chikhale, Prashant J ^a,b  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Anticancer agents; Blood brain barrier; Drug delivery systems; Large neutral amino acid transporter; Melphalan; P glycoprotein

Indexed keywords

ACIVICIN; ANTINEOPLASTIC AGENT; GLYCOPROTEIN; LEUCINE; MELPHALAN; TRACER; VERAPAMIL;

AMINO ACID TRANSPORT; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN METABOLISM; BRAIN PERFUSION; CAPILLARY WALL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG STRUCTURE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; BLOOD-BRAIN BARRIER; BRAIN; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; ISOXAZOLES; MALE; MELPHALAN; P-GLYCOPROTEIN; PERFUSION; PRODRUGS; RADIOACTIVE TRACERS; RATS; RATS, SPRAGUE-DAWLEY; VERAPAMIL;

ANIMALIA;

EID: 0035116415     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00031.x     Document Type: Article

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