Sing the genome electric: Excited cells adjust their splicing

PLoS Biology

Volumn 5, Issue 2, 2007, Pages 0141-0143

  Ares Jr , Manuel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; SMALL NUCLEAR RNA;

CELL CYCLE; GENOME; HUMAN; NONHUMAN; PROTEIN FUNCTION; REGULATORY MECHANISM; RNA SPLICING; SHORT SURVEY; SPLICEOSOME; ALTERNATIVE RNA SPLICING; GENETICS; METABOLISM; NERVE CELL; NERVE CONDUCTION; NOTE; PHYSIOLOGY;

ALTERNATIVE SPLICING; GENOME, HUMAN; HUMANS; NEURAL CONDUCTION; NEURONS; RNA, MESSENGER; SPLICEOSOMES;

EID: 33846993391     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0050055     Document Type: Short Survey

References (27)

1. An P, Grabowski PJ (2007) Exon silencing by UAGG motifs in response to neuronal excitation. PLoS Biol 5: e36. doi:10.1371/journal.pbio.0050036
2. Lee JA, Xing Y, Nguyen D, Xie J, Lee CJ, et al. (2007) Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS Biol 5: e40. doi:10.1371/journal.pbio.0050040
3. Black DL (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72: 291-336.
4. Soares LMM, Zanier K, Mackereth C, Sattler M, Valcárcel J (2006) Intron removal requires proofreading of U2AF/3′ splice site recognition by DEK. Science 312: 1961-1965.
5. Chew SL, Liu HX, Mayeda A, Krainer AR (1999) Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A. 96: 10655-10660.
6. Lim SR, Hertel KJ (2004) Commitment to splice site pairing coincides with A complex formation. Mol Cell. 15: 477-483.
7. Jurica MS, Moore MJ (2003) Pre-mRNA splicing: Awash in a sea of proteins. Mol Cell 12: 5-14.
8. Caceres JF, Stamm S, Helfman DM, Krainer AR. (1994) Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science. 265: 1706-1709.
9. Thanaraj TA, Clark F, Muilu J (2003) Conservation of human alternative splice events in mouse. Nucleic Acids Res 31: 2544-2552.
10. Brudno M, Gelfand MS, Spengler S, Zorn M, Dubchak I, et al. (2001) Computational analysis of candidate intron regulatory elements for tissue specific alternative pre-mRNA splicing. Nucleic Acids Res 29: 2338-2348.
11. Sugnet CW, Kent WJ, Ares M Jr, Haussler D (2004) Transcriptome and genome conservation of alternative splicing events in humans and mice. Pac Symp Biocomput 2004: 66-77.
12. Sorek R, Ast G (2003) Intronic sequences flanking alternatively spliced exons are conserved between human and mouse. Genome Res 13: 1631-1637.
13. Yeo GW, Van Nostrand E, Holste D, Poggio T, Burge CB (2005) Identification and analysis of alternative splicing events conserved in human and mouse. Proc Natl Acad Sci U S A. 102: 2850-2855.
14. Ule J, Ule A, Spencer J, Williams A, Hu JS, et al. (2005) Nova regulates brain-specific splicing to shape the synapse. Nat Genet 37: 844-852.
15. Grabowski PJ, Black DL (2001) Alternative RNA splicing in the nervous system. Prog Neurobiol 65: 289-308.
16. Black DL, Grabowski PJ (2003) Alternative pre-mRNA splicing and neuronal function. Prog Mol Subcell Biol 31: 187-216.
17. Bell L, Horabin JI, Schedl P, Cline TW (1991) Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila. Cell 65: 229-239.
18. Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: Diversity, development and disease. Curr Opin Neurobiol 11: 327-335.
19. Carroll RC, Zukin RS (2002) NMDA-receptor trafficking and targeting: Implications for synaptic transmission and plasticity. Trends Neurosci 25: 571-577.
20. Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, et al. (1997) Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem 272: 5157-5166.
21. Ehlers MD, Zhang S, Bernhadt JP, Huganir RL (1996) Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit. Cell 84: 745-755.
22. Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, et al. (1998) Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci 18: 2017-2027.
23. Ehlers MD, Fung ET, O'Brien RJ, Huganir RL (1998) Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments. J Neurosci 18: 720-730.
24. Bradley J, Carter SR, Rao VR, Wang J, Finkbeiner S (2006) Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J Neurosci 26: 1065-1076.
25. Mu Y, Otsuka T, Horton AC, Scott DB, Ehlers MD (2003) Activitydependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron 40: 581-594.
26. Xie J, Black DL (2001) A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels. Nature 410: 936-939.
27. Shin C, Manley JL (2002) The SR protein SRp38 represses splicing in M phase cells. Cell 111: 407-417.