Mass spectrometry-assisted protease substrate screening

Analytical Chemistry

Volumn 79, Issue 3, 2007, Pages 1251-1255

  Schluter, Hartmut ^a   Rykl, Jana ^a   Thiemann, Joachim ^a   Kurzawski, Sandra ^a   Gobom, Johan ^a   Tepel, Martin ^a   Zidek, Walter ^a   Linscheid, Michael ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; MASS SPECTROMETRY; PROTEINS; SUBSTRATES;

FIBRINOPEPTIDES; HUMAN PLASMA;

GENETIC ENGINEERING;

FIBRINOGEN; FIBRINOPEPTIDE; PLASMA PROTEIN; PROTEINASE; THROMBIN;

ARTICLE; AUTOMATION; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME SUBSTRATE; GENE SEQUENCE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INCUBATION TIME; MASS SPECTROMETRY; NORMAL HUMAN; PROTEIN DEGRADATION; PROTEIN IMMOBILIZATION; REACTION ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

BLOOD PROTEINS; FIBRINOGEN; HUMANS; PEPTIDE HYDROLASES; PEPTIDES; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY; THROMBIN;

EID: 33846988305     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac061482l     Document Type: Article

References (13)

1. Puente, X. S.; Sanchez, L. M.; Overall, C. M.; Lopez-Otin, C. Nat Rev Genet 2003, 4, 544-558.
2. Southan, C. Drug Discovery Today 2001, 6, 681-688.
3. Zhu, Q.; Uttamchandani, M.; Li, D.; Lesaicherre, M. L.; Yao, S. Q. Org. Lett. 2003, 5, 1257-1260.
4. Turk, B. E.; Huang, L. L.; Piro, E. T.; Cantley, L. C. Nat. Biotechnol. 2001, 19, 661-667.
5. Rosse, G.; Kueng, E.; Page, M. G.; Schauer-Vukasinovic, V.; Giller, T.; Lahm, H. W.; Hunziker, P.; Schlatter, D. J. Comb. Chem. 2000, 2, 461-466.
6. Schluter, H.; Jankowski, J.; Rykl, J.; Thiemann, J.; Belgardt, S.; Zidek, W.; Wittmann, B.; Pohl, T. Anal. Bioanal. Chem. 2003, 377, 1102-1107.
7. Jankowski, J.; Stephan, N.; Knobloch, M.; Fischer, S.; Schmaltz, D.; Zidek, W.; Schluter, H. Anal. Biochem. 2001, 290, 324-329.
8. Gobom, J.; Nordhoff, E.; Mirgorodskaya, E.; Ekman, R.; Roepstorff, P. J. Mass Spectrom. 1999, 34, 105-116.
9. Blomback, B. M.; Blomback, P.; Edman, P.; Hessel, B. Biochim. Biophys. Acta 1966, 115, 371-396
10. Profumo, A.; Turci, M.; Damonte, G.; Ferri, F.; Magatti, D.; Cardinali, B.; Cuniberti, C.; Rocco, M. Biochemistry 2003, 42, 12335-12348.
11. Henschen-Edman, A. H. Ann. N. Y. Acad. Sci. 2001, 936, 580-593.
12. Serrano, S. M.; Shannon, J. D.; Wang, D.; Camargo, A. C.; Fox, J. W. Proteomics 2005, 5, 501-510
13. Saghatelian, A.; Trauger, S. A.; Want, E. J.; Hawkins, E. G.; Siuzdak, G.; Cravatt, B. F. Biochemistry 2004, 43, 14332-14339.