Tacrolimus (FK506) limits accumulation of granulocytes and platelets and protects against brain damage after transient focal cerebral ischemia in rat

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 2, 2007, Pages 313-317

  Noto, Takahisa ^a   Furuichi, Yasuhisa ^a   Ishiye, Masayuki ^a   Matsuoka, Nobuya ^a   Aramori, Ichiro ^a   Mutoh, Seitaro ^a   Yanagihara, Takehiko ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b Osaka Neurological Research Institute   (Japan)

Author keywords

Adhesion molecules; Granulocyte; Hypoxia; Platelet; Rat; Transient focal ischemia

Indexed keywords

2 NITROIMIDAZOLE; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MICROTUBULE ASSOCIATED PROTEIN 2; PADGEM PROTEIN; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BRAIN CORTEX; BRAIN DAMAGE; BRAIN HYPOXIA; CELL AGGREGATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GRANULOCYTE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVOUS TISSUE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; THROMBOCYTE; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; BLOOD PLATELETS; BRAIN ISCHEMIA; CELL ADHESION; CEREBRAL CORTEX; GRANULOCYTES; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEUROPROTECTIVE AGENTS; NITROIMIDAZOLES; RATS; RATS, WISTAR; TACROLIMUS;

EID: 33846977719     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.313     Document Type: Article

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