How the doctor's words affect the patient's brain

Evaluation and the Health Professions

Volumn 25, Issue 4, 2002, Pages 369-386

  Benedetti, Fabrizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; DIPYRONE; DOPAMINE; KETOROLAC; NALOXONE; OPIATE; PLACEBO; TRAMADOL; NARCOTIC ANALGESIC AGENT; OPIATE PEPTIDE; OPIATE RECEPTOR;

ANALGESIA; BRAIN; BRAIN REGION; DEPRESSION; DOCTOR PATIENT RELATION; DRUG EFFICACY; HUMAN; NEUROBIOLOGY; NURSE; PAIN; PHYSICIAN; PHYSICIAN ATTITUDE; REVIEW; ARTICLE; BRAIN LEVEL; DRUG EFFECT; METABOLISM; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

ANALGESICS, OPIOID; BRAIN CHEMISTRY; HUMANS; OPIOID PEPTIDES; PAIN; PHYSICIAN-PATIENT RELATIONS; PLACEBO EFFECT; PLACEBOS; RECEPTORS, OPIOID;

EID: 0036884615     PISSN: 01632787     EISSN: None     Source Type: Journal    
DOI: 10.1177/0163278702238051     Document Type: Review

References (67)

1. Ader, R. (1997). The role of conditioning in pharmacotherapy. In A. Harrington (Ed.), The placebo effect: An interdisciplinary exploration (pp. 138-165). Cambridge, MA: Harvard University Press.
2. Amanzio, M., & Benedetti, F. (1999). Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems. Journal of Neuroscience, 19, 484-494.
3. Amanzio, M., Pollo, A., Maggi, G., & Benedetti, F. (2001). Response variability to analgesics: A role for nonspecific activation of endogenous opioids. Pain, 90, 205-215.
4. Balint, M. (1955). The doctor, his patient, and the illness. Lancet, 1, 683-688.
5. Barsky, A. J., Saintfort, R., Rogers, M. P., & Borus, J. F. (2002). Nonspecific medication side effects and the nocebo phenomenon. Journal of the American Medical Association (JAMA), 287, 622-627.
6. Bass, M. J., Buck, C., Turner, L., Dickie, G., Pratt, G., & Robinson, H. C. (1986). The physician's actions and the outcome of illness in family practice. Journal of Family Practice, 23, 43-47.
7. Beckman, H. B., Markakis, K. M., Suchman, A. L., & Frankel, R. M. (1994). The doctor-patient relationship and malpractice: Lessons from plaintiff depositions. Archives of Internal Medicine, 154, 1365-1370.
8. Benedetti, F. (1996). The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain, 64, 535-543.
9. Benedetti, F. (1997). Cholecystokinin type-A and type-B receptors and their modulation of opioid analgesia. News in Physiological Sciences, 12, 263-268.
10. Benedetti, F., & Amanzio, M. (1997). The neurobiology of placebo: From endogenous opioids to cholecystokinin. Progress in Neurobiology, 52, 109-125.
11. Benedetti, F., Amanzio, M., Baldi, S., Casadio, C., Cavallo, A., Mancuso, M., et al. (1998). The specific effects of prior opioid exposure on placebo analgesia and placebo respiratory depression. Pain, 75, 313-319.
12. Benedetti, F., Amanzio, M., Baldi, S., Casadio, C., & Maggi, G. (1999b). Inducing placebo respiratory depressant responses in humans via opioid receptors. European Journal of Neuroscience, 11, 625-631.
13. Benedetti, F., Amanzio, M., Casadio, C., Oliaro, A., & Maggi, G. (1997). Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain, 71, 135-140.
14. Benedetti, F., Amanzio, M., & Maggi, G. (1995). Potentiation of placebo analgesia by proglumide. Lancet, 346, 1231.
15. Benedetti, F., Arduino, C., & Amanzio, M. (1999a). Somatotopic activation of opioid systems by target-directed expectations of analgesia. Journal of Neuroscience, 19, 3639-3648.
16. Benedetti, F., & Pollo, A. (2001). The pharmacology of placebos. International Journal of Pain Medicine and Palliative Care, 1, 42-48.
17. Brody, H. (1988). The symbolic power of the modern personal physician: The placebo response under challenge. Journal of Drug Issues, 29, 149-161.
18. Brody, H. (2000a). The placebo response. New York: HarperCollins.
19. Brody, H. (2000b). The placebo response: Recent research and implications for family medicine. Journal of Family Practice, 49, 649-654.
20. Cassileth, B. R., Lusk, E. J., Miller, D. S., Brown, L. L., & Miller, C. (1985). Psychosocial correlates of survival in advanced malignant disease? New England Journal of Medicine, 312, 1551-1555.
21. Chaput de Saintonge, D. M., & Herxheimer, A. (1994). Harnessing placebo effects in health care. Lancet, 344, 995-998.
22. de la Fuente-Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001). Expectation and dopamine release: Mechanism of the placebo effect in Parkinson's disease. Science, 293, 1164-1166.
23. Di Blasi, Z., Harkness, E., Ernst, E., Georgiou, A., & Kleijnen, J. (2001). Influence of context effects on health outcomes: A systematic review. Lancet, 357, 757-762.
24. Egbert, L. D., Battit, G. E., Turndorf, H., & Beecher, H. K. (1963). The value of the preoperative visit by an anesthetist. JAMA, 185, 553-555.
25. Egbert, L. D., Battit, G. E., Welch, C. E., & Bartlett, M. K. (1964). Reduction of postoperative pain by encouragement and instruction of patients. New England Journal of Medicine, 270, 825-827.
26. Goetz, C. G., Leurgans, S., Raman, R., & Stebbins, G. T. (2000). Objective changes in motor function during placebo treatment in Parkinson's disease. Neurology, 54, 710-714.
27. Gracely, R. H., Dubner, R., Deeter, W. R., & Wolskee, P. J. (1985). Clinicians' expectations influence placebo analgesia. Lancet, 1, 43.
28. Gracely, R. H., Dubner, R., Wolskee, P. J., & Deeter, W. R. (1983). Placebo and naloxone can alter postsurgical pain by separate mechanisms. Nature, 306, 264-265.
29. Greenfield, S., Kaplan, S., & Ware, J. E. (1985). Expanding patient involvement in care. Annals of Internal Medicine, 102, 520-528.
30. Grevert, P., Albert, L. H., & Goldstein, A. (1983). Partial antagonism of placebo analgesia by naloxone. Pain, 16, 129-143.
31. Guess, H. A., Kleinman, A., Kusek, J. W., & Engel, L. W. (Eds.). (2002). The science of the placebo: Toward an interdisciplinary research agenda. London: British Medical Journal Books.
32. Hahn, R. A. (1985). A sociocultural model of illness and healing. In L. White, B. Tursky, & G. E. Schwartz (Eds.), Placebo: Theory, research, and mechanisms (pp. 167-195). New York: Guilford.
33. Hahn, R. A. (1997). The nocebo phenomenon: Scope and foundations. In A. Harrington (Ed.), The placebo effect: An interdisciplinary exploration (pp. 56-76). Cambridge, MA: Harvard University Press.
34. Harrington, A. (Ed.). (1997). The placebo effect: An interdisciplinary exploration. Cambridge, MA: Harvard University Press.
35. Hróbjartsson, A., & Gøtzsche, P. C. (2001). Is the placebo powerless? New England Journal of Medicine, 344, 1594-1602.
36. Inui, T. S., Yourtee, E. L., & Williamson, J. W. (1976). Improved outcomes in hypertension after physician tutorials. Annals of Internal Medicine, 84, 646-651.
37. Kaplan, S. H., Greenfield, S., & Ware, J. E., Jr. (1989). Assessing the effects of physician-patient interactions on the outcomes of chronic disease. Medical Care, 27(Suppl. 3), S110-S127.
38. Kirsch, I. (Ed.). (1999). How expectancies shape experience. Washington, DC: American Psychological Association.
39. Kirsch, I., & Weixel, L. J. (1988). Double-blind versus deceptive administration of a placebo. Behavioral Neuroscience, 102, 319-323.
40. Leuchter, A. F., Cook, I. A., Witte, E. A., Morgan, M., & Abrams, M. (2002). Changes in brain function of depressed subjects during treatment with placebo. American Journal of Psychiatry, 159, 122-129.
41. Levine, J. D., & Gordon, N. C. (1984). Influence of the method of drug administration on analgesic response. Nature, 312, 755-756.
42. Levine, J. D., Gordon, N. C., & Fields, H. L. (1978). The mechanisms of placebo analgesia. Lancet, 2, 654-657.
43. Levine, J. D., Gordon, N. C., Smith, R., & Fields, H. L. (1981). Analgesic responses to morphine and placebo in individuals with postoperative pain. Pain, 10, 379-389.
44. Levinson, W. (1994). Physician-patient communication: A key to malpractice prevention. JAMA, 272, 1619-1620.
45. Lipman, J. J., Miller, B. E., Mays, K. S., Miller, M. N. North, W. C., & Byrne, W. L. (1990). Peak B endorphin concentration in cerebrospinal fluid: Reduced in chronic pain patients and increased during the placebo response. Psychopharmacology, 102, 112-116.
46. Mayberg, H. S., Silva, A. J., Brannan, S. K., Tekell, J. L., Mahurin, R. K., McGinnis, S., et al. (2002). The functional neuroanatomy of the placebo effect. American Journal of Psychiatry, 159, 728-737.
47. Moerman, D. E. (2002). Meaningful dimensions of medical care. In H. A. Guess, A. Kleinman, J. W. Kusek, & L. W. Engel (Eds.), The science of the placebo: Toward an interdisciplinary research agenda. London: BMJ Books.
48. Moerman, D. E., & Jonas, W. B. (2002). Deconstructing the placebo effect and finding the meaning response. Annals of Internal Medicine, 136, 471-476.
49. Montgomery, G. H., & Kirsch, I. (1997). Classical conditioning and the placebo effect. Pain, 72, 107-113.
50. Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002). Placebo and opioid analgesia Imaging a shared neuronal network. Science, 295, 1737-1740.
51. Pollo, A., Amanzio, M., Arslanian, A., Casadio, C., Maggi, G., & Benedetti, F. (2001). Response expectancies in placebo analgesia and their clinical relevance. Pain, 93, 77-84.
52. Pollo, A., Torre, E., Lopiano, L., Rizzone, M., Lanotte, M., Cavanna, et al. (2002). Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients. NeuroReport, 13, 1383-1386.
53. Price, D. D., Milling, L. S., Kirsch, I., Duff, A., Montgomery, G. H., & Nicholls, S. S. (1999). An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain, 83, 147-156.
54. Price, D. D. (2001). Assessing placebo effects without placebo groups: An untapped possibility? Pain, 90, 201-203.
55. Rowbotham, D. J. (2001). Endogenous opioids, placebo response, and pain. Lancet, 357, 1901-1902.
56. Shetty, N., Friedman, J. H., Kieburtz, K., Marshall, F. J., & Oakes, D. (1999). The placebo response in Parkinson's disease. Parkinson study group. Clinical Neuropharmacology, 22, 207-212.
57. Sox, H. C., Margulies, I., & Sox, C. H. (1981). Psychologically mediated effects of diagnostic tests. Annals of Internal Medicine, 95, 680-685.
58. Spiegel, D., Bloom, J. R., Kraemer, H. C., & Gottheil, E. (1989). Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet, 2, 888-891.
59. Starfield, B., Wray, C., Hess, K., Gross, R., Birk, P. S., & D'Lugoff, B. C. (1981). The influence of patient-practitioner agreement on outcome of care. American Journal of Public Health, 71, 127-132.
60. Stewart, M. A. (1995). Effective physician-patient communication and health outcomes: A review. Canadian Medical Association Journal, 152, 1423-1433.
61. Stewart, M. A., McWhinney, I. R., & Buck, C. W. (1979). The doctor-patient relationship and its effect upon outcome. Journal of Royal College of General Practice, 29, 77-82.
62. Thomas, K. B. (1987). General practice consultations: Is there any point in being positive? British Medical Journal, 294, 1200-1202.
63. Thomas, K. B. (1994). The placebo in general practice. Lancet, 344, 1066-1067.
64. Thong, Y. H. (1995). The shaman factor. World Health Forum, 16, 238-240.
65. Turner, J. A., Deyo, R. A., Loeser, J. D., Von Korff, M., & Fordyce, W. E. (1994). The importance of placebo effects in pain treatment and research. JAMA, 271, 1609-1614.
66. White, L., Tursky, B., & Schwartz, G. E. (Eds.). (1985). Placebo: Theory, research, and mechanisms. New York: Guilford.
67. Wohrl, S., & Hemmer, W. (2001). Placebos and pain management. Lancet, 358, 1101-1102.