Inferior olivary inactivation abolishes conditioned eyeblinks: Extinction or cerebellar malfunction?

Behavioural Brain Research

Volumn 178, Issue 1, 2007, Pages 128-138

  Zbarska, S ^a   Holland, E A ^a   Bloedel, J R ^a   Bracha, V ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Classical conditioning; Inferior olive; Interposed nucleus; Rabbit

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CEREBELLUM DISEASE; CONDITIONING; CONTROLLED STUDY; DRUG DIFFUSION; EYELID REFLEX; INFERIOR OLIVE; INTERPOSITUS NUCLEUS; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; REINFORCEMENT;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; CEREBELLUM; CONDITIONING, CLASSICAL; CONDITIONING, EYELID; EXCITATORY AMINO ACID AGENTS; EXTINCTION, PSYCHOLOGICAL; GABA AGONISTS; MALE; MUSCIMOL; NEURAL PATHWAYS; NEURONS; OLIVARY NUCLEUS; RABBITS; RECEPTORS, GLUTAMATE;

EID: 33846965248     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.12.012     Document Type: Article

References (31)

1. Aksenov D., Serdyukova N., Irwin K., and Bracha V. GABA neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity. J Neurophysiol 91 (2004) 719-727
2. Batini C., Billard J.M., and Daniel H. Long-term modification of cerebellar inhibition after inferior olive degeneration. Exp Brain Res 59 (1985) 404-409
3. Benedetti F., Montarolo P.G., Strata P., and Tempia F. Inferior olive inactivation decreases the excitability of the intracerebellar and lateral nuclei in the rat. J Physiol 340 (1983) 195-208
4. Bengtsson F., Svensson P., and Hesslow G. Feedback control of Purkinje cell activity by the cerebello-olivary pathway. Eur J Neurosci 20 (2004) 2999-3005
5. Billard J.M., Batini C., and Daniel H. The red nucleus activity in rats deprived of the inferior olivary complex. Behav Brain Res 28 (1988) 127-130
6. Bracha V., Webster M.L., Winters N.K., Irwin K.B., and Bloedel J.R. Effects of muscimol inactivation of the cerebellar interposed-dentate nuclear complex on the performance of the nictitating membrane response. Exp Brain Res 100 (1994) 453-468
7. Bracha V., Zhao L., Irwin K., and Bloedel J.R. Intermediate cerebellum and conditioned eyeblinks. Parallel involvement in eyeblinks and tonic eyelid closure. Exp Brain Res 136 (2001) 41-49
8. Clark R.E., Zhang A.A., and Lavond D.G. The importance of cerebellar cortex and facial nucleus in acquisition and retention of eyeblink/NM conditioning: evidence for critical unilateral regulation of the conditioned response. Neurobiol Learn Mem 67 (1997) 96-111
9. Gellman R., Houk J.C., and Gibson A.R. Somatosensory properties of the inferior olive of the cat. J Comp Neurol 215 (1983) 228-243
10. Gibson A.R., Horn K.M., and Pong M. Inhibitory control of olivary discharge. Ann NY Acad Sci 978 (2002) 219-231
11. Hiraoka M., and Shimamura M. Neural mechanisms of the corneal blinking reflex in cats. Brain Res 125 (1977) 265-275
12. Holstege G. Neuronal organization of the blink reflex. In: Paxinos G. (Ed). The human nervous system (1990), Academic Press, San Diego 287-296
13. Ito M. The cerebellum and neural control (1984), Raven Press, New York pp. 256-77
14. Krupa D.J., and Thompson R.F. Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response. Learn Mem 3 (1997) 545-556
15. Krupa D.J., Weng J., and Thompson R.F. Inactivation of brainstem motor nuclei blocks expression but not acquisition of the rabbit's classically conditioned eyeblink response. Behav Neurosci 110 (1996) 219-227
16. Lang E.J. Organization of olivocerebellar activity in the absence of excitatory glutamatergic input. J Neurosci 21 (2001) 1663-1675
17. Lang E.J. GABAergic and glutamatergic modulation of spontaneous and motor-cortex-evoked complex spike activity. J Neurophysiol 87 (2002) 1993-2008
18. Lang E.J., Sugihara I., and Llinas R. GABAergic modulation of complex spike activity by the cerebellar nucleoolivary pathway in rat. J Neurophysiol 76 (1996) 255-275
19. McCormick D.A., Steinmetz J.E., and Thompson R.F. Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Res 359 (1985) 120-130
20. McCormick D.A., and Thompson R.F. Cerebellum: essential involvement in the classically conditioned eyelid response. Science 223 (1984) 296-299
21. Medina J.F., Nores W.L., and Mauk M.D. Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses. Nature 416 (2002) 330-333
22. Montarolo P.G., Palestini M., and Strata P. The inhibitory effect of the olivocerebellar input on the cerebellar Purkinje cells in the rat. J Physiol 332 (1982) 187-202
23. Ryan S.B., Detweiler K.L., Holland K.H., Hord M.A., and Bracha V. A long-range, wide field-of-view infrared eyeblink detector. J Neurosci Methods 152 (2006) 74-82
24. Ryan SB, Zbarska S, Holland EA, Bracha V. Does blocking glutamate in the inferior olive make the cerebellum forgetful or dysfunctional? Soc Neurosci Abstr; 2004.
25. Thompson R.F. The neurobiology of learning and memory. Science 233 (1986) 941-947
26. Weiss C., Disterhoft J.F., Gibson A.R., and Houk J.C. Receptive fields of single cells from the face zone of the cat rostral dorsal accessory olive. Brain Res 605 (1993) 207-213
27. Welsh J.P., and Harvey J.A. Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J Neurosci 9 (1989) 299-311
28. Welsh J.P., and Harvey J.A. Acute inactivation of the inferior olive blocks associative learning. Eur J Neurosci 10 (1998) 3321-3332
29. Yeo C.H., Hardiman M.J., and Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit. I. Lesions of the cerebellar nuclei. Exp Brain Res 60 (1985) 87-98
30. Yeo C.H., Hardiman M.J., and Glickstein M. Classical conditioning of the nictitating membrane response of the rabbit. IV. Lesions of the inferior olive. Exp Brain Res 63 (1986) 81-92
31. Zbarska S, Holland EA, Irwin KB, Bloedel JR, Bracha V. Inactivation of inferior olive: extinction of conditioned eyeblinks or performance deficit? Soc Neurosci Abstr; 2003.