Ageing and the gut

Postgraduate Medical Journal

Volumn 83, Issue 975, 2007, Pages 44-53

  D'Souza, A L ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTACID AGENT; BISPHOSPHONIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PROTON PUMP INHIBITOR; RANITIDINE;

ANEMIA; ARTICLE; CELIAC DISEASE; CLINICAL FEATURE; COLORECTAL CANCER; DISEASE SEVERITY; DIVERTICULOSIS; DUODENUM ULCER; ESOPHAGITIS; ESOPHAGUS CARCINOMA; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DISEASE; GASTROINTESTINAL SYMPTOM; HELICOBACTER INFECTION; HUMAN; IRRITABLE COLON; MALABSORPTION; NUTRITIONAL ASSESSMENT; PEPTIC ULCER; PERNICIOUS ANEMIA;

AGED; ANEMIA; GASTROINTESTINAL DISEASES; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; ISCHEMIA; MESENTERY; MOUTH DISEASES;

EID: 33846964131     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.2006.049361     Document Type: Article

References (112)

1. Orimo H. Reviewing the definition of 'elderly'. Nippon Ronen Igakkai Zasshi (Japanese) 2006;43:27-34.
2. Baum BJ, Bodner L. Aging and oral motor function: evidence for altered performance among older persons. J Dent Res 1983;62:2-6.
3. Castell DO, Donner MW. Evaluation of dysphagia: a careful history is crucial. Dysphagia 1987;2:65-71.
4. Murray J, Langmore SE, Ginsberg S, et al. The significance of accumulated oropharyngeal secretions and swallowing frequency in predicting aspiration. Dysphagia 1996;11:99-103.
5. Langmore SE. Evaluation of oropharyngeal dysphagia - which diagnostic tool is superior? Current Opinion Otolaryngology, Head and Neck Surgery 2003;11:485-9.
6. Perlman AL, Christensen J. In:, Perlman AL, Schultze-Delrieu K, eds. Deglutition and its disorders. Location: Singular Publishing Group, 1997:15-42.
7. Shaker R, Staff D. Esophageal disorders in the elderly. Gastroenterol Clin North Am 2001;30:335-61.
8. El-Serag HB, Sonnenberg A. Associations between different forms of gastroesophageal reflux disease. Gut 1997;41:594-9.
9. Connor MJ, Weston A, Mayo MS, et al. Prevalence of Barrett's esophagus and erosive esophagitis in patients undergoing endoscopy for dyspepsia. Gastrointestinal Endoscopy 2002;55:AB199.
10. Locke GR 3rd. The epidemiology of functional gastrointestinal disorders in North America. Gastroenterol Clin North Am 1996;25:1-19.
11. Ramirez FC. Diagnosis and treatment of GERD in the elderly patient. Cleveland Clin J Med 2000;67:755-65.
12. Dent J. Patterns of lower esophageal function associated with GERD. Am J Med 1997;103(suppl):29-32.
13. Klauser AG, Schindlbeck NE, Muller-Lisner SA. Symptoms in GERD. Lancet 1990;335:205-8.
14. Triadafilopoulos G, Sharma R. Features of symptomatic GERD in elderly patients. Am J Gastroenterol 1997;92:2007-11.
15. Jaspersen D, Schwacha H, Schorr W, et al. Omeprazole in treatment of patients with complicated GERD. J Gastroenterol Hepatol 1996;11:900-2.
16. Brotze SA, McElhinney C, Weston A, et al. Prevalence of Barrett's in patients with chronic GERD. Gastrointestinal Endoscopy 2002;55:AB203.
17. Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049-53.
18. Cameron AJ. Epidemiology of columnar-lined esophagus and adenocarcinoma. Gastroenterol Clin North Am 1997;26:487-94.
19. Inadomi JM, Sampliner R, Lagergren J, et al. Screening and surveillance for Barrett's esophagus in high-risk groups: a cost utility analysis. Ann Intern Med 2003;138:176-86.
20. Yeom JS, Park HJ, Cho JS, et al. Reflux esophagitis and its relationship to hiatal hernia. J Korean Med Sci 1999;14:253-6.
21. Trus TL, Laycock WS, Wo JM, et al. Laparoscopic antireflux surgery in the elderly. Am J Gastroenterol 1998;93:351-3.
22. Spechler SJ, Lee E, Ahnen D, et al. Long-term outcome of medical and surgical therapies for GERD: follow-up of a randomized controlled trial. JAMA 2001;285:2331-8.
23. Sollano JD. Non-pharmacologic treatment strategies in GERD. J Gastroenterol Hepatol 2004;19:S44-8.
24. De Groen PC, Lubbe DF, Hirsch U, et al. GERD and the use of bisphosphonates. N Engl J Med 1996;335:1016-21.
25. Spechler SJ, Jain SK, Tendler DA, et al. Racial differences in the frequency of symptoms and complications of gastro-esophageal reflux disease. Aliment Pharmacol Ther 2002;16:1795-800.
26. El-Serag HB, Sonnenberg A, Jamal MM, et al. Corpus gastritis is protective against reflux esophagitis. Gut 1999;45:181-5.
27. Holcombe C. Helicobacter pylori: the African enigma. Gut 1992;33:429-31.
28. Chalasani N, Wo JM, Waring JP. Racial differences in the histology, location and risk factors of esophageal cancer. J Clin Gastroenterol 1998;26:11-13.
29. Kelsen D. Multimodality therapy for adenocarcinoma of the esophagus. Gastroenterol Clin North Am 1997;26:635-45.
30. Walsh TN, NoonanN, Hollywood D, et al. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;335:300-7.
31. Acunas B, Poyanli A, Rozanes I. Intervention in the gastrointestinal tract: treatment of esophageal, gastroduodenal and colorectal obstruction with metallic stents. Eur J Radiol 2002;42:240-8.
32. Cryer B, Redfern S, Goldscheidt M, et al. Effect of ageing on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 1992;102:1118-23.
33. Feldman M, Cryer B, McArthur KE, et al. Effects of ageing and gastritis on gastric acid and pepsin secretion in humans: a prospective study. Gastroenterology 1996;110:1043-52.
34. Kaplan RC, Heckbert SR, Koepsell TD, et al. Risk factors for hospitalized gastrointestinal bleeding among older persons. J Am Geriatric Soc 2001;49:126-33.
35. Aalykke C, Lauristen K. Epidemiology of NSAID-related gastroduodenal mucosal injury. Best Prac Res Clin Gastroenterol 2001;15:704-22.
36. Lanas AL. Current approaches to reducing gastrointestinal toxicity of low-dose aspirin. Am J Med 2001;110:70-3S.
37. Marshall BJ. Helicobacter pylori. Am J Gastroenterol 1994;89:S116-28.
38. Christie C, Janssens JP, Armenian B, et al. Midazolam sedation for upper gastrointestinal endoscopy in older persons: a randomized, double-blind, placebo-controlled study. J Am Geriatric Soc 2000;48:1398-403.
39. Lanas A, Fuentes J, Benito R, et al. Helicobacter pylori increases the risk of upper gastrointestinal bleeding in patients taking low dose aspirin. Aliment Pharmacol Ther 2002;16:779-86.
40. Seinela L, Ahvenainen J. Peptic ulcer in the very old patient. Gerontology 2000;46:271-5.
41. Lai KC, Lau CS, Ip WY, et al. Effect of treatment of Helicobacter pylori on the prevention of gastroduodenal ulcers in patients receiving long-term NSAIIDs: a double-blind, placebo-controlled trial. Aliment Pharmacol Ther 2003;17:799-805.
42. Chan FK, To KF, Wu JC, et al. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomized trial. Lancet 2002;359:9-13.
43. Jyotheeswaran S, Shah AN, Jin HO, et al. Prevalence of Helicobacter pylori in peptic ulcer patients in Greater Rochester, NY: is empirical triple therapy justified? Am J Gastroenterol 1998;93:574-8.
44. Howden CW. Clinical expression of Helicobacter pylori infection. Am J Med 1996;100:27-32S.
45. Klein PD, Malaty HM, Martin RF, et al. Non-invasive detection of Helicobacter pylori infection in clinical practice: the C13 urea breath test. Am J Gastroenterol 1996;91:690-4.
46. Abdalla AM, Sordillo EM, Hanzely Z, et al. Insensitivity of the CLO test for H. pylori in the elderly. Gastroenterology 1998;115:243-4.
47. Rabeneck L, Graham DY. Helicobacter pylori: when to test, when to treat. Ann Intern Medicine 1997;126:315-16.
48. Drazen JM. COX-2 inhibitors - a lesson in unexpected problems (comment). N Engl J Med 2005;352:1131-2.
49. Russell, RM. Factors in aging that effect the bioavailability of nutrients. J Nutrition 2001;131(suppl):1359-61S.
50. Holt PR, Balint JA. Effects of aging on intestinal lipid absorption. Am J Physiol 1993;26:G1-6.
51. Arora S, Kassarjian Z, Krasinski SD, et al. Effect of age on tests of intestinal and hepatic function in healthy humans. Gastroenterology 1989;96:1560-5.
52. Borum ML. Malabsorption in the elderly. In: Beers MH, eds. Merck Manual of Geriatrics. 3rd ed, Location: publisher, 2004.
53. Loft DE. Epidemiology and diagnosis of celiac disease. Eur J Gastro Hepatol 1993;5:69-72.
54. Swinson CM, Levi AJ. Is celiac disease underdiagnosed? BMJ 1980;281:1258-61.
55. Gasbarrini G, Ciccocioppo R, De Vitus I, et al. Celiac disease in the elderly. Gerontology 2001;47:306-10.
56. Hankey GI, Holmes GKJ. Celiac disease in the elderly. Gut 1994;35:65-7.
57. Tai V, Crowe M, O'Keefe S. Celiac disease in older people. J Am Geriatr Soc 2000;48:1690-6.
58. Collin P, Reunala T, Pukkala E, et al. Celiac disease - associated disorders and survival. Gut 1994;35:1215-18.
59. Sorell L, Garrote JA, Acevedo B, et al. One-step immunochromatographic assay for screening of celiac disease. Lancet 2002;359:945-6.
60. Holmes GKT, Prior P, Lane MR, et al. Malignancy in celiac disease - effect of a gluten-free diet. Gut 1989;30:333-8.
61. Andrès E, Kaltenbach G, Perrin AE, et al. Food cobalamin malabsorption in the elderly. Am J Med 2002;113:351-2.
62. Carmel R. Current concepts in cobalamin deficiency. Ann Rev Med 2000;51:357-75.
63. Andrès E, Loukili NH, Noel E, et al. Vitamin B12 deficiency in elderly. CMAJ 2004;171:251-9.
64. Lewis SJ, Potts LF, Malhotra R, et al. Small bowel bacterial overgrowth in subjects living in residential care homes. Age Ageing 1999;28:181-5.
65. Toh BH, Van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med 1997;337:1441-8.
66. Conrad ME, Umbreit JN. Iron absorption and transport - an update. Am J Hematol 2000;64:287-98.
67. Leodolter A, Kahl S, Dominguez-Munoz JE, et al. Comparison of two tubeless function tests inn the assessment of mild-to-moderate exocrine pancreatic insufficiency. Eur J Gastroenterol Hepatol 2000;12:1335-8.
68. Dharmarajan TS, Adiga GU, Norkus EP. Vitamin B12 deficiency: recognizing subtle symptoms in older adults. Geriatrics 2003;58:30-8.
69. Farthing MJG. Diarrhea: a significant worldwide problem. Int J Antimicrob Agents 2000;14:65-69.
70. Ryan MJ, Wall PG, Adak GK, et al. Outbreaks of infectious intestinal disease in residential institutions in England and Wales 1992-1994. J Infect 1997;34:49-54.
71. Brandt LJ, Kosche KA, Greenwald DA, et al. Clostridium difficile-associated diarrhea in the elderly. Am J Gastroenterol 1999;94:3263-6.
72. Ratnaike RN, Jones TE. Mechanisms of drug-induced diarrhea in the elderly. Drugs Ageing 1998;13:24-53.
73. Hebuterne X. Gut changes attributed to aging: effects on intestinal microflora. Curr Opin Clin Nutr Metab Care 2003;6:3-7.
74. D'Souza AL, Rajkumar C, Cooke J, et al. Probiotics in the prevention of antibiotic-associated diarrhea: a meta-analysis. BMJ 2002;324:1361-4.
75. Zoli M, Iervese T, Abbati S, et al. Portal blood velocity and flow in aging man. Gerontology 1989;35:61-5.
76. Kozuch PL, Brandt LJ. Diagnosis and management of mesenteric ischemia with an emphasis on pharmacotherapy. Aliment Pharmacol Ther 2005;21:201-15.
77. Gennaro M, Ascer E, Matano R, et al. Acute mesenteric ischemia after cardiopulmonary bypass. Am J Surg 1993;166:2321-36.
78. Finucaine PM, Arunachalam T, O'Dowd J, et al. Acute mesenteric infarction in elderly patients. J Am Geriatr Soc 1989;37:355-8.
79. Greenwald DA, Brandt LJ, Reinus JF. Ischemic bowel disease in the elderly. Gastroenterol Clin North Am 2001;35:445-52.
80. Park WM, Gloviczki P, Cherry KJ, et al. Contemporary management of acute mesenteric ischemia: factors associated with survival. J Vasc Surg 2002;35:445-52.
81. Merkel IS, Locher J, Burgio K, et al. Physiological and psychological characteristics of an elderly population with chronic constipation. Am J Gastroenterol 1993;88:1854-9.
82. Talley NJ, Fleming KC, Evans JM, et al. Constipation in an elderly community: a study of prevalence and potential risk factors. Am J Gastroenterol 1996;91:19-25.
83. O'Keefe EA, Talley NJ, Zinsmeister AR, et al. Bowel disorders impair functional status and quality of life in the elderly: A population-based study. J Gerontol A Biol Sci Med Sci 1995;50:M184-9.
84. Bannister JJ, Abouzekry L, Read NW. Effect of aging on anorectal function. Gut 1987;28:353-7.
85. Gwee K-A, Leong Y-L, Graham C, et al. The role of psychological and biological factors in post-infectious gut dysfunction. Gut 1999;44:400-6.
86. Freidel D, Krevsky B. Irritable bowel syndrome in the elderly. Clin Geriatr 2000;8:36-47.
87. Camilleri M, Lee JS, Viramontes B, et al. Insights into pathophysiology and mechanisms of constipation, IBS and diverticulosis in older people. J Am Geriatr Soc 2000;48:1142-50.
88. Ahn J, Ehrenpreis ED. Emerging treatments for irritable bowel syndrome. Expert Opin Pharmacother 2002;3:9-21.
89. Truelove SC. Movements of the large intestine. Physiology Rev 1996;46:457-512.
90. Farrell RJ, Farrell JJ, Morrin MM. Diverticular disease in the elderly. Gastroenterol Clin North Am 2001;30:475-96.
91. Schoetz Jr DJ. Diverticular disease of the colon: a century old problem. Dis Colon Rectum 1999;42:703-9.
92. Goh H, Bourne R. Non-steroidal anti-inflammatory drugs and perforated diverticular disease: a case-control study. Ann Rev Coll Surg Engl 2002;84:93-6.
93. Hart AR, Kennedy HJ, Stebbings WS, et al. How frequently do large bowel diverticula perforate: an incidence and cross-sectional study. Eur J Gastroenterol Hepatol 2002;12:661-5.
94. Connell AM. Applied physiology of the colon: factors relevant to diverticular disease. Clin Gastroenterol 1975;4:23-6.
95. Parks TG. Natural history of diverticular disease of the colon. Clin Gastroenterol 1975;4:53-69.
96. Makela J, Vuolio S, Kiviniemi H, et al. Natural history of diverticular disease: when to operate? Dis Col Rectum 1998;41:1523-8.
97. Marlett JA, McBurney MI, Slavin JL. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 2002;102:993-1000.
98. American Cancer Society. Cancer facts and figures 2003.
99. Bronner MP, Haggitt RC. The polyp-cancer sequence: do all colorectal cancers arise from benign adenomas? Gastrointest Endosc Clin North Am 1993;3:611-22.
100. Schoen RE. Families at risk for colorectal cancer: risk assessment and genetic testing. J Clin Gastroenterol 2000;31:114-20.
101. Au HJ, Mulder KE, Fields AL. Systematic review of management of colorectal cancer in elderly patients. Clin Colorectal Cancer 2003;3:165-71.
102. Selby JV. Colorectal cancer screening - keeping options open. Eff Clin Pract 2001;4:39-41.
103. Samet J, Hunt WC, Key C, et al. Choice of cancer therapy varies with age of the patient. JAMA 1986;255:3385-90.
104. McCardle CS, Hole DJ. Outcome following surgery for colorectal cancer. Br Med Bull 2002;64:119-25.
105. British Colorectal Collaborative Group. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000;356:968-74.
106. Lacy AM, Garcia-Valdecasas JC, Delgado S, et al. Laparoscopy-assisted colectomy versus colectomy for treatment of non-metastatic colon cancer: a randomized trial. Lancet 2002;359:2224-9.
107. Efron DT, Bender JS. Laparoscopic surgery in older patients. J Am Geriatr Soc 2001;49:658-63.
108. Fata F, Mirza A, Wood GC, et al. Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma. Cancer 2002;94:1931-8.
109. O'Connell MJ, Martenson JA, Wieand HS, et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 1994;331:502-7.
110. Baron TH, Dean PH, Yates MR, et al. Expandable metal stents for the treatment of colonic obstruction: techniques and outcomes. Gastrointest Endosc 1998;47:277-86.
111. Florie J, van Gelder RE, Stoker J. Colonography by computed tomography. Eur J Gastroenterol Hepatol 2005;17:809-13.
112. Rockey DC, Paulson E, Medzwiecki D, et al. Analysis of air-contrast barium enema, CT Colonography and colonoscopy: a prospective comparison. Lancet 2005;365:305-11.