Induced expression of cathepsins and cystatin C in a murine model of demyelination

Neurochemical Research

Volumn 32, Issue 2, 2007, Pages 311-320

  Ma, Jianmei ^a,b   Tanaka, Kenji F ^b   Yamada, Gen ^b   Ikenaka, Kazuhiro ^b  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Brain; Cathepsin; Cystatin C; Demyelination; In situ hybridization

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN H; CATHEPSIN L; CYSTATIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEMYELINATION; DNA MICROARRAY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; UPREGULATION;

AGING; ANIMALS; ASTROCYTES; CALCIUM-BINDING PROTEINS; CATHEPSIN B; CATHEPSINS; CYSTATINS; CYSTEINE ENDOPEPTIDASES; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MACROPHAGES; MICE; MICE, TRANSGENIC; MICROGLIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; UP-REGULATION;

ANIMALIA; MURINAE; MUS;

EID: 33846913495     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9183-y     Document Type: Article

References (19)

1. Chang A, Nishiyama A, Peterson J et al (2000) NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions. J Neurosci 20:6404-6412
2. Scolding N, Franklin R, Stevens S et al (1998) Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain 121:2221-2228
3. Kagawa T, Ikenaka K, Inoue Y et al (1994) Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 13:427-442
4. Ma J, Matsumoto M, Tanaka K et al (2006) An animal model for late onset chronic demyelinaion disease caused by failed terminal differentiation of oligodendrocyte. Neuron Glia Biol 2:81-91
5. Guyton M, Sribnick E, Wingrave J et al (2004) Axon damage and neuronal death in multiple sclerosis and experimental autoimmune encephalomyelitis: the role of calpain. In: Multiple Sclerosis as a neuronal disease. Elsevier, London, pp 295
6. Bever CT Jr, Garver DW (1995) Increased cathepsin B activity in multiple sclerosis brain. J Neurol Sci 131:71-73
7. Nagai A, Murakawa Y, Terashima M et al (2000) Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. Neurology 55:1828-1832
8. Irani DN, Anderson C, Gundry R et al (2006) Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis. Ann Neurol 59:237-247
9. Gan L, Ye S, Chu A, Anton K et al (2004) Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. J Biol Chem 279:5565-5572
10. Quackenbush J (2003) Microarrays - guilt by association. Science 302:240-241
11. Brzin J, Popovic T, Turk V et al (1984) Human cystatin, a new protein inhibitor of cysteine proteinases. Biochem Biophys Res Commun 118:103-109
12. Barrett AJ, Davies ME, Grubb A et al (1984) The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun 120:631-636
13. Grubb AO (2000) Cystatin C - properties and use as diagnostic marker. Adv Clin Chem 35:63-99
14. Banati RB, Rothe G, Valet G et al (1993) Detection of lysosomal cysteine proteinases in microglia: flow cytometric measurement and histochemical localization of cathepsin B and L. Glia 7:183-191
15. Lignelid H, Collins VP, Jacobsson B (1997) Cystatin C and transthyretin expression in normal and neoplastic tissues of the human brain and pituitary. Acta Neuropathol 93:494-500
16. Norenberg MD, Martinez-Hernandez A (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 161:303-310
17. Bever CT Jr, Panitch HS, Johnson KP (1994) Increased cathepsin B activity in peripheral blood mononuclear cells of multiple sclerosis patients. Neurology 44:745-748
18. Ponomarev ED, Shriver LP, Maresz K, Dittel BN (2005) Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J Neurosci Res 81:374-389
19. Gan L, Ye S, Chu A, Anton K et al (2004) Identification of cathepsin B as a mediator of neuronal death induced by Aβ-activated microglial cells using a functional genomics approach. J Biol Chem 279: 5565-5572