Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 5, 2007, Pages 1211-1215

  Brescia, Marc Raleigh ^a   Rokosz, Laura L ^a   Cole, Andrew G ^a   Stauffer, Tara M ^a   Lehrach, John M ^a   Auld, Douglas S ^a   Henderson, Ian ^a   Webb, Maria L ^a  

^a PHARMACOPEIA INC   (United States)

Author keywords

ECLiPS ; Inflammation; Pain; PGI2; Prostacyclin; Prostanoid receptors

Indexed keywords

AMIDE; CYCLIC AMP; PROSTACYCLIN RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; EMBRYO; HUMAN; HUMAN CELL; IC 50; THROMBOCYTE MEMBRANE;

AMIDES; HUMANS; INHIBITORY CONCENTRATION 50; OXAZOLES; POLYCYCLIC HYDROCARBONS, AROMATIC; RECEPTORS, PROSTAGLANDIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846906293     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.025     Document Type: Article

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