Influence of conformation and intramolecular hydrogen bonding on the acyl glucuronidation and biliary excretion of acetylenic bis-dipyrrinones related to bilirubin

Journal of Medicinal Chemistry

Volumn 50, Issue 3, 2007, Pages 480-488

  McDonagh, Antony F ^a   Lightner, David A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; ALKYL GROUP; BILIRUBIN; BILIRUBIN DERIVATIVE; BILIVERDIN; CARBOXYL GROUP; DICARBOXYLIC ACID DERIVATIVE; GLUCURONOSYLTRANSFERASE; MULTIDRUG RESISTANCE PROTEIN 2; PYRROLE DERIVATIVE; TETRAPYRROLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BILE FLOW; BILIRUBIN METABOLISM; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EXCRETION; GLUCURONIDATION; LIVER METABOLISM; MALE; MOLECULAR DYNAMICS; NONHUMAN; RAT; RAT STRAIN;

ALKYNES; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; BILIRUBIN; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HYDROGEN BONDING; LIVER; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846901538     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0609521     Document Type: Article

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