Kv1.1 null mice have enlarged hippocampus and ventral cortex

BMC Neuroscience

Volumn 8, Issue , 2007, Pages

  Persson, Ann Sophie ^a,c   Westman, Eric ^a   Wang, Fu Hua ^a,b   Khan, Firoj Hossain ^a,d   Spenger, Christian ^a   Lavebratt, Catharina ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL KV1.1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; BRAIN CORTEX; BRAIN SIZE; CEPHALOMETRY; CONTROLLED STUDY; FEMALE; GENE LOSS; GENE MUTATION; GENE TRANSFER; HETEROZYGOTE; HIPPOCAMPUS; IN VIVO STUDY; MACROCEPHALY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; SEIZURE; THREE DIMENSIONAL IMAGING; WILD TYPE;

ANIMALS; BRAIN DISEASES; CEREBRAL CORTEX; HIPPOCAMPUS; HYPERTROPHY; KV1.1 POTASSIUM CHANNEL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT;

EID: 33846897176     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-8-10     Document Type: Article

References (19)

1. Donahue LR Cook SA Johnson KR Bronson RT Davisson MT Megencephaly: A new mouse mutation on chromosome 6 that causes hypertrophy of the brain Mamm Genome 1996 7 871-876 10.1007/s003359900259 8995755
2. Diez M Schweinhardt P Petersson S Wang FH Lavebratt C Schalling M Hokfelt T Spenger C MRI and in situ hybridization reveal early disturbances in brain size and gene expression in the megencephalic (mceph/mceph) mouse Eur J Neurosci 2003 18 3218-3230 10.1111/ j.1460-9568.2003.02994.x 14686896
3. Petersson S Persson AS Johansen JE Ingvar M Nilsson J Klement G Århem P Schalling M Lavebratt C Truncation of the Shaker-like voltage-gated potassium channel, Kv11, causes megencephaly Eur J Neurosci 2003 18 3231-3240 10.1111/j.1460-9568.2003.03044.x 14686897
4. Persson AS Klement G Almgren M Sahlholm K Nilsson J Petersson S Århem P Schalling M Lavebratt C A truncated Kv11 protein in the brain of the megencephaly mouse, expression and interaction BMC Neurosci 2005 6 65 1322225 16305740 10.1186/1471-2202-6-65
5. Lavebratt C Trifunovski A Persson AS Wang FH Klason T Ohman I Josephsson A Olson L Spenger C Schalling M Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse Neurobiol Dis 2006 24 374-383 10.1016/j.nbd.2006.07.018 16990009
6. Petersson S Sandberg Nordqvist A Schalling M Lavebratt C The megencephaly mouse has disturbances in the insulin-like growth factor (IGF) system Brain Res Mol Brain Res 1999 72 80-88 10.1016/ S0169-328X(99)00211-9 10521601
7. Petersson S Lavebratt C Schalling M Hokfelt T Expression of cholecystokinin, enkephalin, galanin and neuropeptide Y is markedly changed in the brain of the megencephaly mouse Neuroscience 2000 100 297-317 10.1016/S0306-4522(00)00285-2 11008168
8. Smart SL Lopantsev V Zhang CL Robbins CA Wang H Chiu SY Schwartzkroin PA Messing A Tempel BL Deletion of the Kv11 potassium channel causes epilepsy in mice Neuron 1998 20 809-819 10.1016/S0896-6273(00)81018-1 9581771
9. Rho JM Szot P Tempel BL Schwartzkroin PA Developmental seizure susceptibility of kv11 potassium channel knockout mice Dev Neurosci 1999 21 320-327 10.1159/000017381 10575255
10. Almgren M Persson AS Witgen BM Schalling M Nyengaard J Lavebratt C Lack of potassium channel induces neurogenesis and survival causing 2-fold hippocampal enlargement Hippocampus Accepted
11. Kempermann G Kuhn HG Gage FH Genetic influence on neurogenesis in the dentate gyrus of adult mice Proc Natl Acad Sci USA 1997 94 10409-10414 23376 9294224 10.1073/pnas.94.19.10409
12. Bengzon J Kokaia Z Elmer E Nanobashvili A Kokaia M Lindvall O Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures Proc Natl Acad Sci USA 1997 94 10432-10437 23380 9294228 10.1073/pnas.94.19.10432
13. Parent JM Yu TW Leibowitz RT Geschwind DH Sloviter RS Lowenstein DH Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus J Neurosci 1997 17 3727-3738 9133393
14. Parent JM Janumpalli S McNamara JO Lowenstein DH Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat Neurosci Lett 1998 247 9-2 10.1016/S0304-3940(98)00269-9 9637397
15. McKhann GM 2nd Wenzel HJ Robbins CA Sosunov AA Schwartzkroin PA Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology Neuroscience 2003 122 551-561 10.1016/S0306-4522(03)00562-1 14614919
16. Schauwecker PE Steward O Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches Proc Natl Acad Sci USA 1997 94 4103-4108 20575 9108112 10.1073/pnas.94.8.4103
17. Hennig J Nauerth A Friedburg H RARE imaging: A fast imaging method for clinical MR Magn Reson Med 1986 3 823 3821461
18. Paxinos G Franklin KBJ The mouse brain in stereotaxic coordinates London: Academic Press 2 2001
19. Racine RJ Modification of seizure activity by electrical stimulation II Motor seizure Electroencephalogr Clin Neurophysiol 1972 32 281-294 10.1016/0013-4694(72)90177-0 4110397