PLGA-dendron nanoparticles enhance immunogenicity but not lethal antibody production of a DNA vaccine against anthrax in mice

International Journal of Pharmaceutics

Volumn 331, Issue 2, 2007, Pages 228-232

  Ribeiro, Suzie ^a   Rijpkema, Sjoerd G ^b   Durrani, Zarmina ^b   Florence, Alexander T ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Dendriplexes; DNA vaccines; Nanoparticles; PLGA; Protective antigen

Indexed keywords

CARBON; DENDRIMER; DNA VACCINE; HYDROCARBON; IMMUNOGLOBULIN G ANTIBODY; NAKED DNA; NANOPARTICLE; POLYGLACTIN; RECOMBINANT ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTHRAX; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; BACILLUS ANTHRACIS; BAGG ALBINO MOUSE; BIOPHYSICAL EQUIPMENT; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; EMULSION; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE VECTOR; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NONHUMAN; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STANDARD;

ANIMALS; ANTHRAX; ANTIBODIES, VIRAL; ANTIBODY FORMATION; ANTIGENS, VIRAL; BACILLUS ANTHRACIS; DENDRIMERS; DRUG CARRIERS; IMMUNITY; IMMUNIZATION; LACTIC ACID; MICE; MICE, INBRED BALB C; NANOPARTICLES; POLYGLYCOLIC ACID; POLYMERS; VACCINES, DNA;

EID: 33846889120     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.11.063     Document Type: Article

References (20)

1. Fellows P.F., Linscott M.K., Ivins B.E., Pitt M.L., Rossi C.A., Gibbs P.H., and Friedlander A.M. Efficacy of a human anthrax vaccine in guinea pigs, rabbits, and rhesus macaques against challenge by Bacillus anthracis isolates of diverse geographical origin. Vaccine 19 (2001) 3241-3247
2. Gupta R.K., Singh M., and O'Hagan D.T. Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines. Adv. Drug Deliv. Rev. 32 (1998) 225-246
3. Hahn U.K., Alex M., Czerny C.P., Bohm R., and Beyer W. Protection of mice against challenge with Bacillus anthracis STI spores after DNA vaccination. Int. J. Med. Microbiol. 294 (2004) 35-44
4. Hahn U.K., Boehm R., and Beyer W. DNA vaccination against anthrax in mice-combination of anti-spore and anti-toxin components. Vaccine 24 (2005) 4569-4571
5. Hahn U.K., Aichler M., Boehm R., and Beyer W. Comparison of the immunological memory after DNA vaccination and protein vaccination against anthrax in sheep. Vaccine 21 (2005) 4597-4607
6. Halpern M.D., Kurlander R.J., and Pisetsky D.S. Bacterial DNA induces murine interferon-gamma production by stimulation of IL-12 and tumor necrosis factor alpha. Cell. Immunol. 167 (1996) 72-78
7. Hering D., Thompson W., Hewetson J., Little S., Norris S., and Pace-Templeton J. Validation of the anthrax lethal toxin neutralization assay. Biologicals 32 (2004) 17-27
8. Jiang W., Gupta R.K., Deshpande M.C., and Schwendeman S.P. Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug Deliv. Rev. 57 (2005) 391-410
9. Jilek S., Ulrich M., Merkle H.P., and Walter E. Composition and surface charge of DNA-loaded microparticles determine maturation and cytokine secretion in human dendritic cells. Pharm. Res. 21 (2004) 1240-1247
10. Jones A.J., Putney S., Johnson O.L., and Cleland J.L. Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development. Adv. Drug Deliv. Rev. 28 (1997) 71-84
11. Klinman D.M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4 (2004) 249-258
12. Mize K.S., Dupuis M., Singh M., Woo C., Ugozzoli M., O'Hagan D.T., Donnelly III J.J., Ott G., and McDonald D.M. Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles. Cell Immunol. 225 (2003) 12-20
13. Mize K.S., Dupuis M., MacKichan M.L., Singh M., Doe B., O'Hagan D., Ulmer J.B., Donnelly J.J., McDonald D.M., and Ott G. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells. Gene Ther. 7 (2000) 2105-2112
14. Pittman P.R., Kim-Ahn G., Pifat D.Y., Coonan K., Gibbs P., Little S., Pace-Templeton J.G., Myers R., Parker G.W., and Friedlander A.M. Anthrax vaccine: immunogenicity and safety of a dose-reduction, route-change comparison study in humans. Vaccine 20 (2002) 1412-1420
15. Ribeiro S., Hussain N., and Florence A.T. Release of DNA from dendriplexes encapsulated in PLGA nanoparticles. Int. J. Pharm. 298 (2005) 354-360
16. Sheets E.E., Urban R.G., Crum C.P., Hedley M.L., Politch J.A., Gold M.A., Muderspach L.I., Cole G.A., and Crowley-Nowick P.A. Immunotherapy of human cervical high-grade cervical intraepithelial neoplasia with microparticle-delivered human papillomavirus 16 E7 plasmid DNA. Am. J. Obstet. Gynecol. 188 (2003) 916-926
17. Singh M., Vajdy M., Gardner J., Briones M., and O'Hagan D. Mucosal immunization with HIV-1 gag DNA on cationic microparticles prolongs gene expression and enhances local and systemic immunity. Vaccine 20 (2001) 594-602
18. Singh M., Kazzaz J., Ugozzoli M., Chesko J., and O'Hagan D.T. Charged polylactide-co-glycolide microparticles as antigen delivery systems. Expert. Opin. Biol. Ther. 4 (2004) 483-491
19. Turnbull P.C. Current status of immunization against anthrax: old vaccines may be here to stay for a while. Curr. Opin. Infect. Dis. 13 (2000) 113-120
20. Xie H., Gursel I., Ivins B.E., Singh M., O'Hagan D.T., Ulmer J.B., and Klinman D.M. CpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccine. Infect. Immun. 73 (2005) 828-833