Effect of immunisation against gonadotrophin releasing hormone isoforms (mammalian GnRH-I, chicken GnRH-II and lamprey GnRH-III) on murine spermatogenesis

Vaccine

Volumn 25, Issue 11, 2007, Pages 2051-2063

  Khan, Mohammad A H ^a   Prevost, Martine ^b   Waterston, Mary M ^c   Harvey, Michael J A ^c   Ferro, Valerie A ^d  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Active immunisation; GnRH isoforms; Spermatogenesis

Indexed keywords

FOLLITROPIN; GONADORELIN; GONADOTROPHIN RELEASING HORMONE I; GONADOTROPHIN RELEASING HORMONE II; GONADOTROPHIN RELEASING HORMONE III; ISOPROTEIN; TESTOSTERONE; TETANUS TOXOID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; COMPUTER MODEL; CONJUGATION; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FERTILITY; FOLLITROPIN BLOOD LEVEL; HISTOLOGY; IMMUNIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANTIBODIES; CHICKENS; COMPUTER SIMULATION; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HISTOCYTOCHEMISTRY; LAMPREYS; MALE; MICE; MICE, INBRED BALB C; MODELS, ANIMAL; OLIGOPEPTIDES; PEPTIDES; PROTEIN ISOFORMS; PYRROLIDONECARBOXYLIC ACID; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTIS; TESTOSTERONE; TETANUS TOXOID; VACCINES, CONTRACEPTIVE; VACCINES, SUBUNIT;

EID: 33846886350     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.11.038     Document Type: Article

References (37)

1. Schally A.V., Arimura A., and Kastin A.J. Hypothalamic regulatory hormones. Science 179 (1973) 341-350
2. Millar R.P. GnRHs and GnRH receptors. Anim Reprod Sci 88 (2005) 5-28
3. Chartrel N., Collin F., Huang Y.S., Montero M., Tonon M.C., Goos H.J., et al. Characterization and localization of two forms of gonadotropin-releasing hormone (GnRH) in the spinal cord of the frog Rana ridibunda. Cell Tissue Res 293 (1998) 235-243
4. Chen A., Yahalom D., Ben-Aroya N., Kaganovsky E., Okon E., and Koch Y. A second isoform of gonadotropin-releasing hormone is present in the brain of human and rodents. FEBS Lett 435 (1998) 199-203
5. Dees W.L., Hiney J.K., Sower S.A., Yu W.H., and McCann S.M. Localization of immunoreactive lamprey gonadotropin-releasing hormone in the rat brain. Peptides 20 (1999) 1503-1511
6. Yahalom D., Chen A., Ben-Aroya N., Rahimipour S., Kaganovsky E., Okon E., et al. The gonadotropin-releasing hormone family of neuropeptides in the brain of human, bovine and rat: identification of a third isoform. FEBS Lett 463 (1999) 289-294
7. Neill J.D., Musgrove L.C., and Duck L.W. Newly recognized GnRH receptors: function and relative role. Trends Endocrinol Metabol 15 (2004) 383-392
8. Maudsley S., Davidson L., Pawson A.J., Chan R., de Maturana R.L., and Millar R.P. Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotic signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor. Cancer Res 64 (2004) 7533-7544
9. Temple J.L., Millar R.P., and Rissman E.F. An evolutionarily conserved form of gonadotropin-releasing hormone coordinates energy and reproductive behavior. Endocrinol 144 (2003) 13-19
10. Kauffman A.S. Emerging functions of gonadotropin-releasing hormone II in mammalian physiology and behaviour. J Neuroendocrinol 16 (2004) 794-806
11. Siler-Khodr T.M., and Grayson M. Action of chicken II GnRH on the human placenta. J Clin Endocrinol Metabol 86 (2001) 804-810
12. Siler-Khodr T.M., Grayson M., and Eddy C.A. Action of gonadotropin-releasing hormone II on the baboon ovary. Biol Reprod 68 (2003) 1150-1156
13. Hiney J.K., Sower S.A., Yu W.H., McCann S.M., and Dees W.L. Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides. Proc Natl Acad Sci USA 99 (2002) 2386-2391
14. Yu W.H., Karanth S., Mastronardi C.A., Sealfon S., Dean C., Dees W.L., et al. GnRH-III acts on its putative receptor via nitric oxide to release follicle-stimulating hormone specifically. Exp Biol Med (Maywood) 227 (2002) 786-793
15. Lovas S., Palyi I., Vincze B., Horvath J., Kovacs M., Mezo I., et al. Direct anticancer activity of gonadotropin-releasing hormone-III. J Pept Res 52 (1998) 384-389
16. Montaner A.D., Mongiat L., Lux-Lantos V.A., et al. Structure and biological activity of gonadotropin-releasing hormone isoforms isolated from rat and hamster brains. Neuroendocrinol 74 (2001) 202-212
17. Kovacs M., Seprodi J., Koppan M., Horvath J.E., Vincze B., Teplan I., et al. Lamprey gonadotropin hormone-releasing hormone-III has no selective follicle-stimulating hormone-releasing effect in rats. J Neuroendocrinol 14 (2002) 647-655
18. Amstalden M., Zieba D.A., Garcia M.R., Stanko R.L., Welsh Jr. T.H., Hansel W.H., et al. Evidence that lamprey GnRH-III does not release FSH selectively in cattle. Reproduction 127 (2004) 35-43
19. Pawson A.J., Morgan K., Maudsley S.R., and Millar R.P. Type II gonadotrophin-releasing hormone (GnRH-II) in reproductive biology. Reproduction 126 (2003) 271-278
20. Millar R.P., Lu Z.L., Pawson A.J., Flanagan C.A., Morgan K., and Maudsley S.R. Gonadotropin-releasing hormone receptors. End Rev 25 (2004) 235-275
21. Gault P.M., Maudsley S., and Lincoln G.A. Evidence that gonadotropin-releasing hormone II is not a physiological regulator of gonadotropin secretion in mammals. J Neuroendocrinol 15 (2003) 831-839
22. Ferro V.A., Khan M.A.H., McAdam D., Colston A., Aughey E., Mullen A.B., et al. Efficacy of an anti-fertility vaccine based on mammalian gonadotrophin releasing hormone (GnRH-I)-a histological comparison in male animals. Vet Immunol Immunopathol 101 (2004) 73-86
23. Thompson D.L. Immunization against GnRH in male species (comparative aspects). Anim Reprod Sci 60-61 (2000) 459-469
24. Ferro V.A., Khan M.A.H., Latimer V.S., Brown D., Urbanski H.F., and Stimson W.H. Immunoneutralisation of GnRH-I, without cross-reactivity to GnRH-II, in the development of a highly specific anti-fertility vaccine for clinical and veterinary use. J Reprod Immunol 51 (2001) 109-129
25. Brooks B.R., Bruccoleri R.E., Olafson B.D., States D.J., Swaminathan D.S., and Karplus M. CHARMM: a program for macromolecular energy minimization and molecular dynamics. J Comp Chem 4 (1983) 187-217
26. Schaefer M. A comprehensive analytical treatment of continuum electrostatics. J Comp Chem 100 (1996) 1578-1599
27. Antibody image modified from http://www.biology.arizona.edu/IMMUNOLOGY/tutorials/antibody/structure.html.
28. Ferro V.A. Current advances in anti-fertility vaccines for fertility control and non-contraceptive applications. Expert Rev Vaccines 1 (2002) 443-452
29. Turkstra J.A., Schaaper W.M.M., Oonk H.B., and Meloen R.H. GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms. Vaccine 23 (2005) 4915-4920
30. Bowen A., Khan S., Berghman L., Kirby J.D., Wettemann R.P., and Vizcarra J.A. Immunization of pigs against chicken gonadotropin-releasing hormone-II and lamprey gonadotropin-releasing hormone-III: effects on gonadotropin secretion and testicular function. J Anim Sci 84 (2006) 2990-2999
31. Ferro V.A., O'Grady J.E., Notman J., and Stimson W.H. Immunological castration using a gonadotrophin-releasing hormone analogue conjugated to PPD. Food Agric Immunol 7 (1995) 259-272
32. Barran P.E., Roeske R.W., Pawson A.J., et al. Evolution of constrained gonadotropin-releasing hormone ligand conformation and receptor selectivity. J Biol Chem 280 (2005) 38569-38575
33. Moroder L., Musiol H.J., Kocher K., et al. Synthetic immunogens. The effect of the conformational space on biological and immunological responses to dimeric hormone constructs. Eur J Biochem 212 (1993) 325-333
34. Silversides D.W., Allen A.F., Misra V., Qualtiere L., Mapletoft R.J., and Murphy B.D. A synthetic luteinizing hormone releasing hormone vaccine. I. Conjugation and specificity trials in BALB/c mice. J Reprod Immunol 13 (1988) 249-261
35. Craig L., Sanschagrin P.C., Rozek A., Lackie S., Kuhn L.A., and Scott J.K. The role of structure in antibody cross-reacitvity between peptides and folded proteins. J Mol Biol 281 (1998) 183-201
36. Earl E.R., Waterston M.M., Aughey E., Harvey M.J.A., Matschke C., Colston A., et al. Evaluation of two GnRH-I based vaccine formulations on the testes function of entire Suffolk cross ram lambs. Vaccine 24 (2006) 3172-3183
37. McCann S.M., Karanth S., Mastronardi C.A., Dees W.L., Childs G., Miller B., et al. Control of gonadotropin secretion by follicle-stimulating hormone-releasing factor, luteinizing hormone-releasing hormone, and leptin. Arch Med Res 32 (2001) 476-485