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Volumn 87, Issue 1, 2007, Pages 22-26

Absence of an active metabolite for the triazole antifungal pramiconazole

Author keywords

Dermatophyte; Inhibition zone bioassay; Metabolism; R126638; Yeast

Indexed keywords

ANTIFUNGAL AGENT; DRUG METABOLITE; PLACEBO; PRAMICONAZOLE; UNCLASSIFIED DRUG;

EID: 33846884215     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.2340/00015555-0179     Document Type: Article
Times cited : (5)

References (20)
  • 1
    • 0942268851 scopus 로고    scopus 로고
    • Odds F, Ausma J, Van Gerven F, Woestenborghs, Meerpoel L, Heerens J, et al. Activity in vitro and in vivo of a novel azole antifungal agent R126638 Antimicrob Agents Chemother 2004; 43: 388-391.
    • Odds F, Ausma J, Van Gerven F, Woestenborghs, Meerpoel L, Heerens J, et al. Activity in vitro and in vivo of a novel azole antifungal agent R126638 Antimicrob Agents Chemother 2004; 43: 388-391.
  • 2
    • 4344704026 scopus 로고    scopus 로고
    • The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp. and Microsporum canis
    • Vanden Bossche H, Ausma J, Bohets H, Vermuyten K, Willemsens G, Marichal P, et al. The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp. and Microsporum canis. Antimicrob Agents Chemother 2004; 48: 3272-3278.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3272-3278
    • Vanden Bossche, H.1    Ausma, J.2    Bohets, H.3    Vermuyten, K.4    Willemsens, G.5    Marichal, P.6
  • 3
    • 0026761973 scopus 로고
    • Primary cultures of human hepatocytes: A unique system for studies in toxicology, virology, parasitology and liver pathophysiology in man
    • Moshage H, Yap SH. Primary cultures of human hepatocytes: a unique system for studies in toxicology, virology, parasitology and liver pathophysiology in man. J Hepatol 1992; 15: 404-413.
    • (1992) J Hepatol , vol.15 , pp. 404-413
    • Moshage, H.1    Yap, S.H.2
  • 4
    • 0027500871 scopus 로고
    • Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: Studies of interpatient varieties in concentrations
    • Hostetler JS, Heykants J, Clemons KV, Woestenborghs R, Hanson LH, Stevens DA. Discrepancies in bioassay and chromatography determinations explained by metabolism of itraconazole to hydroxyitraconazole: studies of interpatient varieties in concentrations. Antimicrob Agents Chemother 1993; 37: 2224-2227.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 2224-2227
    • Hostetler, J.S.1    Heykants, J.2    Clemons, K.V.3    Woestenborghs, R.4    Hanson, L.H.5    Stevens, D.A.6
  • 5
    • 0029380499 scopus 로고
    • Determination of itraconazole and hydroxy-itraconazole in sera using high-performance liquid chromatography and a bioassay
    • Hülsewede JW, Dermmouni H, Ansorg R. Determination of itraconazole and hydroxy-itraconazole in sera using high-performance liquid chromatography and a bioassay. Zentralbl Bakteriol 1995; 282: 457-464.
    • (1995) Zentralbl Bakteriol , vol.282 , pp. 457-464
    • Hülsewede, J.W.1    Dermmouni, H.2    Ansorg, R.3
  • 7
    • 28744448650 scopus 로고    scopus 로고
    • Placebo-controlled randomized double-blind multiple dose dose-rising trial in healthy volunteers to assess the tolerability, safety and pharmacokinetics of the novel antifungal R126638
    • Ausma J, Bruynseels J, Snoeck E, Blockhuys S, van Rossem K, Borgers M. Placebo-controlled randomized double-blind multiple dose dose-rising trial in healthy volunteers to assess the tolerability, safety and pharmacokinetics of the novel antifungal R126638. J Eur Acad Derm Venereol 2004; 18 (suppl. 2): 392.
    • (2004) J Eur Acad Derm Venereol , vol.18 , Issue.SUPPL. 2 , pp. 392
    • Ausma, J.1    Bruynseels, J.2    Snoeck, E.3    Blockhuys, S.4    van Rossem, K.5    Borgers, M.6
  • 8
    • 0034002752 scopus 로고    scopus 로고
    • Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: In vitro studies of potential co-medication interactions
    • Bohets H, Lavrijsen K, Hendrickx J, Van Houdt J, van Genechten V, Verboven P, et al. Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co-medication interactions. Br J Pharmacol 2000; 129: 1655-1667.
    • (2000) Br J Pharmacol , vol.129 , pp. 1655-1667
    • Bohets, H.1    Lavrijsen, K.2    Hendrickx, J.3    Van Houdt, J.4    van Genechten, V.5    Verboven, P.6
  • 10
    • 9844256470 scopus 로고
    • Protein determination for large number samples
    • Miller GL. Protein determination for large number samples. Anal Chem 1959; 31: 964.
    • (1959) Anal Chem , vol.31 , pp. 964
    • Miller, G.L.1
  • 11
    • 50449100139 scopus 로고
    • The carbon monoxide pigment of liver microsomes. II. Solubilization, purification and properties
    • Omura T, Sato R. The carbon monoxide pigment of liver microsomes. II. Solubilization, purification and properties. J Biol Chem 1964; 239: 2379-2385.
    • (1964) J Biol Chem , vol.239 , pp. 2379-2385
    • Omura, T.1    Sato, R.2
  • 12
    • 0015409143 scopus 로고
    • 2+ on enzymatic dispersion of isolated perfused liver
    • 2+ on enzymatic dispersion of isolated perfused liver. Exp Cell Res 1972; 74: 450-454.
    • (1972) Exp Cell Res , vol.74 , pp. 450-454
    • Seglen, P.O.1
  • 13
    • 0019847093 scopus 로고
    • Isolation and culture of adult hepatocytes from liver biopsies
    • Reese JA, Byard JL. Isolation and culture of adult hepatocytes from liver biopsies. In Vitro 1981; 17: 935-940.
    • (1981) In Vitro , vol.17 , pp. 935-940
    • Reese, J.A.1    Byard, J.L.2
  • 14
    • 0021877049 scopus 로고
    • Simplified bioassay method for measurement of flucytosine or ketoconazole
    • Bodet CA, Jorgensen JH, Drutz DJ. Simplified bioassay method for measurement of flucytosine or ketoconazole. J Clin Microbiol 1985; 22: 157-160.
    • (1985) J Clin Microbiol , vol.22 , pp. 157-160
    • Bodet, C.A.1    Jorgensen, J.H.2    Drutz, D.J.3
  • 15
    • 84988175795 scopus 로고
    • Analytical methods validation: Bioavailability, bioequivalence, and pharmacokinetic studies
    • Shah V, Midha K, Dighe S, McGilveray I, Skelly J, Yacobi A, et al. Analytical methods validation: bioavailability, bioequivalence, and pharmacokinetic studies. J Pharmaceutical Sci 1992; 81: 309-312.
    • (1992) J Pharmaceutical Sci , vol.81 , pp. 309-312
    • Shah, V.1    Midha, K.2    Dighe, S.3    McGilveray, I.4    Skelly, J.5    Yacobi, A.6
  • 16
    • 33846891003 scopus 로고    scopus 로고
    • Guidance for Industry. Bioanalytical method validation. US Department of Health and Human Services. Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary
    • May
    • Guidance for Industry. Bioanalytical method validation. US Department of Health and Human Services. Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), May 2001.
    • (2001) Medicine , vol.1095
  • 18
    • 33846852758 scopus 로고
    • Fluconazole: An overview
    • Fluconazole and its role in vaginal candidiasis. Richardson RG, ed, London: Royal Society of Medicine Services
    • Feczko J: Fluconazole: an overview; In: Fluconazole and its role in vaginal candidiasis. Richardson RG, ed. International Congress and Symposium Series No. 160. London: Royal Society of Medicine Services, 1989: p. 11-18.
    • (1989) International Congress and Symposium Series , vol.160 , pp. 11-18
    • Feczko, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.