Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis [3]

Journal of Applied Physiology

Volumn 102, Issue 2, 2007, Pages 820-821

  Weigert, Cora ^a   Lehmann, Rainer ^a   Schleicher, Erwin D ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INTERLEUKIN 6; GLUCOSE; SOCS3 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; BIOSYNTHESIS; CATABOLISM; EXERCISE; LETTER; MUSCLE METABOLISM; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; METABOLISM; MOUSE; NOTE; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; EXERCISE; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; MICE; MUSCLE, SKELETAL; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 33846873249     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01353.2006     Document Type: Letter

References (6)

1. Blumberg D, Hochwald S, Brennan MF, Burt M. Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes. Metabolism 44: 145-146, 1995.
2. Mooney RA. Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol. In press.
3. Pedersen BK, Febbraio MA. Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol. In press.
4. Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, Jansson JO. Interleukin-6-deficient mice develop matureonset obesity. Nat Med 8: 75-79, 2002.
5. Weigert C, Hennige AM, Brodbeck K, Haring HU, Schleicher ED. Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt. Am J Physiol Endocrinol Metab 289: E251-E257, 2005.
6. Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schauble M, Haring HU, Schleicher ED. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem 281: 7060-7067, 2006.