Esmolol inhibits Na+ current in rat ventricular myocytes

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 28, Issue 10, 2006, Pages 697-702

  Deng, C Y ^a   Lin, Shuguang G ^a   Zhang, W C ^a   Kuang, S J ^a   Qian, W M ^a   Wu, S L ^a   Shan, Z X ^a   Yang, M ^a   Yu, X Y ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Esmolol; Rat ventricular myocytes; Sodium current (INa); Whole cell patch clamp technique

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; ESMOLOL; SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARDIOSELECTIVITY; CONTROLLED STUDY; DRUG MECHANISM; IC 50; MALE; MUSCLE CELL; NONHUMAN; RAT; SODIUM CURRENT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; HEART VENTRICLES; MALE; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 33846871025     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2006.28.10.1037498     Document Type: Article

References (24)

1. Volz-Zang, C., Eckrich, B., Jahn, P., Schneidrowski, B., Schulte, B., Palm, D. Esmolol, an ultrashort-acting, selective beta 1-adrenoceptor antagonist: Pharmacodynamic and pharmacokinetic properties. Eur J Clin Pharmacol 1994, 46: 399-404.
2. Elliott, W.J. Clinical features in the management of selected hypertensive emergencies. Prog Cardiovasc Dis 2006, 48: 316-25.
3. Santhi, R., Worthley, L.I. Hypertension in the critically ill patient. Crit Care Resusc 2003, 5: 24-42.
4. Suzuki, T., Morisaki, H., Serita, R., Yamamoto, M., Kotake, Y., Ishizaka, A. Infusion of the beta-adrenergic blacker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med 2005, 33: 2294-301.
5. Tereshchenko, S.N., Kositsyna, I.V., Dzhaiani, N.A., Golubev, A.V., Kochetov, A.G. [The use of esmolol in patients with myocardial infarction complicated with acute left ventricular failure]. Kardiologiia 2005, 45: 19-22 (in Russian).
6. Iliodromitis, E.K., Tasouli, A., Andreadou, I. et al. Intravenous atenolol and esmolol maintain the protective effect of ischemic preconditioning in vivo. Eur J Pharmacol 2004, 499: 163-9.
7. Daga, M.K., Chaudhary, M., Sharma, B. et al. Effect of esmolol on oxidant status and antioxidant activity in acute myocardial infarction. J Assoc Physicians India 2003, 51: 677-80.
8. Kurosawa, S., Kanaya, N., Niiyama, Y., Nakayama, M., Fujita, S., Namiki, A. Landiolol, esmolol, and propranolol protect from ischemia/reperfusion injury in isolated guinea pig hearts. Can J Anaesth 2003, 50: 489-94.
9. Mitchell, R.G., Stoddard, M.F., Ben-Yehuda, O. et al. Esmolol in acute ischemic syndromes. Am Heart J 2002, 144: E9.
10. Geissler, H.J., Davis, K.L., Laine, G.A. et al. Myocardial protection with high-dose beta-blockade in acute myocardial ischemia. Eur J Cardiothorac Surg 2000, 17: 63-70.
11. Killingsworth, C.R., Wei, C.C., Dell'Italia, L.J. et al. Short-acting beta-adrenergic antagonist esmolol given at reperfusion improves survival after prolonged ventricular fibrillation. Circulation 2004, 109: 2469-74.
12. Balcells, J., Rodriguez, M., Pujol, M., Iglesias, J. Successful treatment of long QT syndrome-induced ventricular tachycardia with esmolol. Pediatr Cardiol 2004, 25: 160-2.
13. Mortiz, F., de La Chapelle, A., Bauer, F., Leroy, J.P., Goulle, J.P., Bonmarchand, G. Esmolol in the treatment of severe arrhythmia after acute trichloroethylene poisoning. Intensive Care Med 2000, 26: 256.
14. Tisdale, J.E., Sun, H., Zhao, H. et al. Antifibrillatory effect of esmolol alone and in combination with lidocaine. J Cardiovasc Pharmacol 1996, 27: 376-82.
15. Mizutani, K., Nakamura, C., Tsuchiya, M., Asada, A. [A comparison of propranolol with esmolol for the treatment of tachycardia during emergence from anesthesia]. Masui 2005, 54: 632-7 (in Japanese).
16. Arlock, P., Wohlfart, B., Sjoberg, T., Steen, S. The negative inotropic effect of esmolol on isolated cardiac muscle. Scand Cardiovasc J 2005, 39: 250-4.
17. Yin, X., Shan, Q., Deng, C., Bourreau, J.P. Effect of SIN-1 in rat ventricular myocytes: Interference with beta-adrenergic stimulation. Life Sci 2002, 71: 287-97.
18. Hamill, O.P., Marty, A., Neher, E., Sakmann, B., Sigworth, F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981, 391: 85-100.
19. Li, G.R., Lau, C.P., Shrier, A. Heterogeneity of sodium current in atrial vs. epicardial ventricular myocytes of adult guinea pig hearts. J Mol Cell Cardiol 2002, 34: 1185-94.
20. Ban, T., Sada, S., Takahashi, Y., Sada, H., Fujita, T. Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol 1985, 329: 77-85.
21. Bean, B.P., Cohen, C.J., Tsien, R.W. Lidocaine block of cardiac sodium channels. J Gen Physiol 1983, 81: 613-42.
22. Cosin, J., Macias, A., Gavira, J.J. et al. [Supraventricular arrhythmia. Potential applications of esmolol]. Rev Med Univ Navarra 2001, 45: 24-30, 33-9 (in Spanish).
23. Weirich, J., Antoni, H. Differential analysis of the frequency-dependent effects of class 1 antiarrhythmic drugs according to periodical ligand binding: Implications for antiarrhythmic and proarrhythmic efficacy. J Cardiovasc Pharmacol 1990, 15: 998-1009.
24. Lawrence, J.H., Yue, D.T., Rose, W.C., Marban, E. Sodium channel inactivation from resting states in guinea-pig ventricular myocytes. J Physiol 1991, 443: 629-50.