How much insulin is enough? A quantitative assessment of the transdifferentiaton potential of liver [1]

Diabetologia

Volumn 50, Issue 3, 2007, Pages 690-692

  Perl, S ^a   Hirshberg, B ^a   Harlan, D M ^a   Tisdale, J F ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; INSULIN; STREPTOZOCIN; TRANSCRIPTION FACTOR PDX 1;

DIABETES MELLITUS; GENE AMPLIFICATION; GENE EXPRESSION; GENE TARGETING; GLUCOSE BLOOD LEVEL; INSULIN SYNTHESIS; LETTER; NONHUMAN; PRIMATE; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMEODOMAIN PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; LIVER; MICE; TRANS-ACTIVATORS;

EID: 33846848930     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0549-0     Document Type: Letter

References (6)

1. Ferber S, Halkin A, Cohen H et al (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6:568-572
2. Tal MG, Hirshberg B, Neeman Z et al (2004) Induction of diabetes in nonhuman primates by means of temporary arterial embolization and selective arterial injection of streptozotocin. Radiology 230:163-168
3. Ber I, Shternhall K, Perl S et al (2003) Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 278:31950-31957
4. Feudtner JC (2003) Bittersweet : diabetes, insulin, and the transformation of illness, vol 2. University of North Carolina Press, Chapel Hill
5. Kojima H, Fujimiya M, Matsumura K et al (2004) Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci USA 101:2458-2463
6. Rajagopal J, Anderson WJ, Kume S et al (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299:363