Characterization of the outer membrane proteome of Leptospira interrogans expressed during acute lethal infection

Infection and Immunity

Volumn 75, Issue 2, 2007, Pages 766-773

  Nally, Jarlath E ^a,c   Whitelegge, Julian P ^a,b   Bassilian, Sara ^a,b   Blanco, David R ^a   Lovett, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; OUTER MEMBRANE PROTEIN; PROTEIN LIPL32; PROTEIN LOA22; PROTEOME; TRITON X 114; UNCLASSIFIED DRUG;

ADAPTATION; ADOLESCENT; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CONVALESCENCE; DISEASE TRANSMISSION; GUINEA PIG; IMMUNOBLOTTING; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GENE EXPRESSION REGULATION, BACTERIAL; GUINEA PIGS; IMMUNOBLOTTING; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; MALE; MASS SPECTROMETRY; MEMBRANE PROTEINS; PROTEOME;

EID: 33846814927     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00741-06     Document Type: Article

References (26)

1. Bharti, A. R., J. E. Nally, J. N. Ricaldi, M. A. Matthias, M. M. Diaz, M. A. Lovett, P. N. Levett, R. H. Gilman, M. R. Willig, E. Gotuzzo, and J. M. Vinetz. 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect. Dis. 3:757-771.
2. Cullen, P. A., S. J. Cordwell, D. M. Bulach, D. A. Haake, and B. Adler. 2002. Global analysis of outer membrane proteins from Leptospira interrogans serovar Lai. Infect. Immun. 70:2311-2318.
3. Cullen, P. A., D. A. Haake, D. M. Bulach, R. L. Zuerner, and B. Adler. 2003. LipL21 is a novel surface-exposed lipoprotein of pathogenic Leptospira species. Infect. Immun. 71:2414-2421.
4. Faine, S., B. Adler, C. Bolin, and P. Perolat. 1999. Leptospira and leptospirosis, 2 ed. MediSci, Melbourne, Australia.
5. Haake, D. A., C. I. Champion, C. Martinich, E. S. Shang, D. R. Blanco, J. N. Miller, and M. A. Lovett. 1993. Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer membrane protein of pathogenic Leptospira spp. J. Bacteriol. 175:4225-4234.
6. Haake, D. A., G. Chao, R. L. Zuerner, J. K. Barnett, D. Barnett, M. Mazel, J. Matsunaga, P. N. Levett, and C. A. Bolin. 2000. The leptospiral major outer membrane protein LipL32 is a lipoprotein expressed during mammalian infection. Infect. Immun. 68:2276-2285.
7. Haake, D. A., C. Martinich, T. A. Summers, E. S. Shang, J. D. Pruetz, A. M. McCoy, M. K. Mazel, and C. A. Bolin. 1998. Characterization of leptospiral outer membrane lipoprotein LipL36: downregulation associated with late-log-phase growth and mammalian infection. Infect. Immun. 66:1579-1587.
8. Haake, D. A., and J. Matsunaga. 2002. Characterization of the leptospiral outer membrane and description of three novel leptospiral membrane proteins. Infect. Immun. 70:4936-4945.
9. Haake, D. A., E. M. Walker, D. R. Blanco, C. A. Bolin, M. N. Miller, and M. A. Lovett. 1991. Changes in the surface of Leptospira interrogans serovar grippotyphosa during in vitro cultivation. Infect. Immun. 59:1131-1140.
10. Koizumi, N., and H. Watanabe. 2003. Molecular cloning and characterization of a novel leptospiral lipoprotein with OmpA domain. FEMS Microbiol. Lett. 226:215-219.
11. Matsunaga, J., T. A. Young, J. K. Barnett, D. Barnett, C. A. Bolin, and D. A. Haake. 2002. Novel 45-kilodalton leptospiral protein that is processed to a 31-kilodalton growth-phase-regulated peripheral membrane protein. Infect. Immun. 70:323-334.
12. Nally, J. E., S. Artiushin, and J. F. Timoney. 2001. Molecular characterization of thermoinduced immunogenic proteins Qlp42 and Hsp15 of Leptospira interrogans. Infect. Immun. 69:7616-7624.
13. Nally, J. E., C. Chantranuwat, X. Y. Wu, M. C. Fishbein, M. M. Pereira, J. J. Da Silva, D. R. Blanco, and M. A. Lovett. 2004. Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis. Am. J. Pathol. 164:1115-1127.
14. Nally, J. E., E. Chow, M. C. Fishbein, D. R. Blanco, and M. A. Lovett. 2005. Changes in lipopolysaccharide O antigen distinguish acute versus chronic Leptospira interrogans infections. Infect. Immun. 73:3251-3260.
15. Nally, J. E., J. F. Timoney, and B. Stevenson. 2001. Temperature-regulated protein synthesis by Leptospira interrogans. Infect. Immun. 69:400-404.
16. Nally, J. E., J. P. Whitelegge, R. Aguilera, M. M. Pereira, D. R. Blanco, and M. A. Lovett. 2005. Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of Leptospira interrogans serovar Copenhageni. Proteomics 5:144-152.
17. Nascimento, A. L., A. I. Ko, E. A. Martins, C. B. Monteiro-Vitorello, P. L. Ho, D. A. Haake, S. Verjovski-Almeida, R. A. Hartskeerl, M. V. Marques, M. C. Oliveira, C. F. Menck, L. C. Leite, H. Carrer, L. L. Coutinho, W. M. Degrave, O. A. Dellagostin, H. El-Dorry, E. S. Ferro, M. I. Ferro, L. R. Furlan, M. Gamberini, E. A. Giglioti, A. Goes-Neto, G. H. Goldman, M. H. Goldman, R. Harakava, S. M. Jeronimo, I. L. Junqueira-de-Azevedo, E. T. Kimura, E. E. Kuramae, E. G. Lemos, M. V. Lemos, C. L. Marino, L. R. Nunes, R. C. de Oliveira, G. G. Pereira, M. S. Reis, A. Schriefer, W. J. Siqueira, P. Sommer, S. M. Tsai, A. J. Simpson, J. A. Ferro, L. E. Camargo, J. P. Kitajima, J. C. Setubal, and M. A. Van Sluys. 2004. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J. Bacteriol. 186:2164-2172.
18. Niwattayakul, K., J. Homvijitkul, O. Khow, and V. Sitprija. 2002. Leptospirosis in northeastern Thailand: hypotension and complications. Southeast Asian J. Trop. Med. Public Health 33:155-160.
19. Ren, S. X., G. Fu, X. G. Jiang, R. Zeng, Y. G. Miao, H. Xu, Y. X. Zhang, H. Xiong, G. Lu, L. F. Lu, H. Q. Jiang, J. Jia, Y. F. Tu, J. X. Jiang, W. Y. Gu, Y. Q. Zhang, Z. Cai, H. H. Sheng, H. F. Yin, Y. Zhang, G. F. Zhu, M. Wan, H. L. Huang, Z. Qian, S. Y. Wang, W. Ma, Z. J. Yao, Y. Shen, B. Q. Qiang, Q. C. Xia, X. K. Guo, A. Danchin, I. Saint Girons, R. L. Somerville, Y. M. Wen, M. H. Shi, Z. Chen, J. G. Xu, and G. P. Zhao. 2003. Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422:888-893.
20. Sehgal, S. C., M. V. Murhekar, and A. P. Sugunan. 1995. Outbreak of leptospirosis with pulmonary involvement in north Andaman. Indian J. Med. Res. 102:9-12.
21. Seijo, A., H. Coto, J. San Juan, J. Videla, B. Deodato, B. Cernigoi, O. G. Messina, O. Collia, D. de Bassadoni, R. Schtirbu, A. Olenchuk, G. D. de Mazzonelli, and A. Parma. 2002. Lethal leptospiral pulmonary hemorrhage: an emerging disease in Buenos Aires, Argentina. Emerg. Infect. Dis. 8:1004-1005.
22. Shang, E. S., T. A. Summers, and D. A. Haake. 1996. Molecular cloning and sequence analysis of the gene encoding LipL41, a surface-exposed lipoprotein of pathogenic Leptospira species. Infect. Immun. 64:2322-2330.
23. Silva, J. J., M. O. Dalston, J. E. Carvalho, S. Setubal, J. M. Oliveira, and M. M. Pereira. 2002. Clinicopathological and immunohistochemical features of the severe pulmonary form of leptospirosis. Rev. Soc. Bras. Med Trop. 35:395-399.
24. Simpson, F. G., K. A. Green, G. J. Haug, and D. L. Brookes. 1998. Leptospirosis associated with severe pulmonary haemorrhage in Far North Queensland. Med. J. Aust. 169:151-153.
25. Trevejo, R. T., J. G. Rigau-Perez, D. A. Ashford, E. M. McClure, C. Jarquin-Gonzalez, J. J. Amador, J. O. de los Reyes, A. Gonzalez, S. R. Zaki, W. J. Shieh, R. G. McLean, R. S. Nasci, R. S. Weyant, C. A. Bolin, S. L. Bragg, B. A. Perkins, and R. A. Spiegel. 1998. Epidemic leptospirosis associated with pulmonary hemorrhage-Nicaragua, 1995. J. Infect. Dis. 178:1457-1463.
26. Zuerner, R. L., W. Knudtson, C. A. Bolin, and G. Trueba. 1991. Characterization of outer membrane and secreted proteins of Leptospira interrogans serovar pomona. Microb. Pathog. 10:311-322.