Direct validation of in vivo localized 13C MRS measurements of brain glycogen

Magnetic Resonance in Medicine

Volumn 57, Issue 2, 2007, Pages 243-248

  Lei, Hongxia ^a   Morgenthaler, Florence ^a   Yue, Tianwen ^a   Gruetter, Rolf ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b EPFL   (Switzerland)

Author keywords

13C MRS; Biochemical validation; Brain glycogen; Hypoglycemia; Metabolism

Indexed keywords

INSULIN; METABOLISM; MICROWAVE IRRADIATION;

BIOCHEMICAL ASSAY; BIOCHEMICAL VALIDATION; BRAIN GLYCOGEN; FOCUSED MICROWAVES; HYPOGLYCEMIA; ISOTOPIC ENRICHMENT; NMR MEASUREMENTS; ^13C MRS;

GLUCOSE;

CARBON 13; GLUCOSE; GLUCOSE C 13; GLYCOGEN; HUMAN INSULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; GLYCOGEN ANALYSIS; HYPERGLYCEMIA; HYPOGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROWAVE IRRADIATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; VALIDATION STUDY;

EID: 33846804495     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21128     Document Type: Article

References (28)

1. Gruetter R. Glycogen: the forgotten cerebral energy store. J Neurosci Res 2003;74:179-183.
2. Brown AM, Tekkok SB, Ransom BR. Glycogen regulation and functional role in mouse white matter. J Physiol 2003;549(Pt 2):501-512.
3. Swanson RA, Choi DW. Glial glycogen stores affect neuronal survival during glucose deprivation in vitro. J Cereb Blood Flow Metab 1993;13:162-169.
4. 13C NMR assessment of brain glycogen concentration and turnover in the awake rat. Neurochem Int 2003;43:317-322.
5. Cruz NF, Dienel GA. High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes. J Cereb Blood Flow Metab 2002;22:1476-1489.
6. Kong J, Shepel PN, Holden CP, Mackiewicz M, Pack AI, Geiger JD. Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep. J Neurosci 2002;22:5581-5587.
7. Choi IY, Tkac I, Gruetter R. Single-shot, three-dimensional "non-echolocalization method for in vivo NMR spectroscopy. Magn Reson Med 2000;44:387-394.
8. 13C]glycogen concentrations and metabolism in rat brain in vivo. J Neurochem 1999;73:1300-1308.
9. Choi IY, Seaquist ER, Gruetter R. Effect of hypoglycemia on brain glycogen metabolism in vivo. J Neurosci Res 2003;72:25-32.
10. Oz G, Henry PG, Seaquist ER, Gruetter R. Direct, noninvasive measurement of brain glycogen metabolism in humans. Neurochem Int 2003;43:323-329.
11. Alonso MD, Lomako J, Lomako WM, Whelan WJ. A new look at the biogenesis of glycogen. FASEB J 1995;9:1126-1137.
12. 13C-NMR relaxation in glycogen. Magn Reson Med 1996;36:45-51.
13. 13C NMR spectroscopy. NMR Biomed 1993;6:84-88.
14. 13C NMR visibility of rabbit muscle glycogen in vivo. Magn Reson Med 1991;20:327-332.
15. 13C NMR measurements of liver glycogen in vivo. Magn Reson Med 1994;31:583-588.
16. 13C NMR quantification of hepatic glycogen. NMR Biomed 1993;6:371-376.
17. Adriany G, Gruetter R. A half-volume coil for efficient proton decoupling in humans at 4 tesla. J Magn Reson 1997;125:178-184.
18. Choi IY, Lee SP, Kim SG, Gruetter R. In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia. J Cereb Blood Flow Metab 2001;21:653-663.
19. Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 2000;43:319-323.
20. 13C NMR study. J Neurochem 2006;99:260-268.
21. Choi IY, Lei H, Gruetter R. Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action. J Cereb Blood Flow Metab 2002;22:1343-1351.
22. Morgenthaler FD, Koski DM, Kraftsik R, Henry PG, Gruetter R. Biochemical quantification of total brain glycogen concentration in rats under different glycemic states. Neurochem Int 2006;48:616-622.
23. Sagar SM, Sharp FR, Swanson RA. The regional distribution of glycogen in rat brain fixed by microwave irradiation. Brain Res 1987;417:172-174,
24. Swanson RA, Morton MM, Sagar SM, Sharp FR. Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography. Neuroscience 1992;51:451-461.
25. 13C-NMR of glutamate metabolism in the human brain: initial results at 4 tesla. Dev Neurosci 1998;20:380-388.
26. Seaquist ER, Damberg GS, Tkac I, Gruetter R. The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/ metabolism in humans. Diabetes 2001;50:2203-2209.
27. de Graaf RA, Pan JW, Telang F, Lee JH, Brown P, Novotay EJ, Hetherington HP, Rothman DL. Differentiation of glucose transport in human brain gray and white matter. J Cereb Blood Flow Metab 2001;21:483-492.
28. Lomako J, Lomako WM, Whelan WJ, Dombro RS, Neary JT, Norenberg MD. Glycogen synthesis in the astrocyte: from glycogenin to proglycogen to glycogen. FASEB J 1993;7:1386-1393.