Degradation of HNE-modified proteins - Possible role of ubiquitin

Redox Report

Volumn 12, Issue 1-2, 2007, Pages 63-67

  Botzen, Diana ^a   Grune, Tilman ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

4 Hydroxynonenal; GAPDH; Proteasome; Ubiquitin

Indexed keywords

4 HYDROXYNONENAL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; POLYUBIQUITIN; PROTEASOME; UBIQUITIN;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; UBIQUITINATION;

ALDEHYDES; ANIMALS; CELL LINE; CRICETINAE; CRICETULUS; FIBROBLASTS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; LYSOSOMES; PROTEINS; UBIQUITIN;

EID: 33846784093     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100007X162130     Document Type: Conference Paper

References (15)

1. Ciechanover A. The ubiquitin-proteasome proteolytic pathway. Cell 1994; 79: 13-21.
2. Grune T, Reinheckel T, Davies KJA. Protein degradation in cultured liver epithelial cells during oxidative stress: role of the multicatalytic proteinase complex, proteasome. J Biol Chem 1995; 270: 2344-2351.
3. Grune T, Reinheckel T, Davies KJA. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem 1996; 271: 15504-15509.
4. Grune T, Reinheckel T, Davies KJA. Degradation of oxidized proteins in mammalian cells. FASEB J 1997; 11: 526-534.
5. Shringarpure R., Grune T, Mehlhase J, Davies KJA. Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem 2003; 278: 311-318.
6. Asher G, Bercovich Z, Tsvetkov P, Shaul Y, Kahana C. 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1. Mol Cell 2005; 17: 645-655.
7. Asher G, Shaul Y. p53 proteasomal degradation: poly-ubiquitination is not the whole story. Cell Cycle 2005; 4: 1015-1018.
8. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11: 81-128.
9. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003; 42: 318-343.
10. Lauderback CM, Hackett JM, Huang FF et al. The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abetal-42. J Neurochem 2001; 78: 413-416.
11. Markesbery WR, Lovell MA. Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiol Aging 1998; 19: 33-36.
12. Uchida K, Stadtman ER. Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal. Proc Natl Acad Sci USA 1992; 89: 5611-5615.
13. Poppek D, Keck S, Ermack G et al. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J 2006; Epub ahead of print.
14. Friguet B, Szweda LI. Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross linked protein. FEBS Lett 1997; 405: 21-25.
15. Marques C, Pereira P, Taylor A et al. Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J 2004; 18: 1424-1426.