Heparin-Induced Thrombocytopenia Following Cardiac Surgery is Associated With Poor Outcome

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 21, Issue 1, 2007, Pages 18-22

  Kuitunen, Anne ^a   Suojaranta Ylinen, Raili ^a   Raivio, Peter ^a   Kukkonen, Sinikka ^a   Lassila, Riitta ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

anticoagulants; blood; cardiopulmonary bypass; HIT; surgery; thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; DALTEPARIN; DANAPAROID; FONDAPARINUX; HEPARIN; LEPIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; THROMBOCYTE ANTIBODY; WARFARIN;

ADULT; AGED; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG SUBSTITUTION; EARLY DIAGNOSIS; ENZYME IMMUNOASSAY; FEMALE; HEART SURGERY; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SURVIVAL; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOEMBOLISM; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

AGED; ANTICOAGULANTS; BIOLOGICAL MARKERS; CARDIAC SURGICAL PROCEDURES; CASE-CONTROL STUDIES; FEMALE; HEPARIN; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; OUTCOME ASSESSMENT (HEALTH CARE); POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; THROMBOCYTOPENIA;

EID: 33846705028     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2006.05.002     Document Type: Article

References (25)

1. Warkentin T.E., Chong B.H., and Greinacher A. Heparin-induced thrombocytopenia: Towards consensus. Thromb Haemost 79 (1998) 1-7
2. Warkentin T.E., Levine M.N., Hirsh J., et al. Heparin-induced thrombocytopenia in patients with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332 (1995) 1330-1335
3. Warkentin T.E., and Kelton J.G. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 334 (2001) 1330-1335
4. Warkentin T.E., and Kelton J.G. A 14-year study of heparin-induced thrombocytopenia. Am J Med 101 (1996) 502-527
5. Warkentin T.E., and Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg 76 (2003) 2121-2131
6. Pouplard C., May M.A., Regina S., et al. Changes in platelet count after cardiac surgery can effectively predict the development of pathogenic heparin-dependent antibodies. Br J Haematol 128 (2005) 837-841
7. Warkentin T.E., Sheppard J.I., Horsewood P., et al. Impact of patient population on the risk for heparin-induced thrombocytopenia. Blood 96 (2000) 1703-1708
8. Trossaert M., Gaillard A., Commin P.L., et al. High incidence of anti-heparin/platelet factor 4 antibodies after cardiopulmonary bypass surgery. Br J Haematol 101 (1998) 653-655
9. Bauer T.L., Arepally G., Konkle B.A., et al. Prevalence of heparin-associated antibodies without thrombosis in patients undergoing cardiopulmonary bypass surgery. Circulation 95 (1997) 1242-1246
10. Konkle B.A., Bauer T.L., Arepally G., et al. Heparin-induced thrombocytopenia: Bovine versus porcine heparin in cardiopulmonary bypass surgery. Ann Thorac Surg 71 (2001) 1920-1924
11. Francis J.L., Plamer G.J., Moroose R., et al. Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery. Ann Thorac Surg 75 (2003) 17-22
12. Eichler P., Budde U., Haas S., et al. First workshop for detection of heparin-induced antibodies: validation of the heparin-induced platelet-activation test (HIPA) in comparison with a PF4/heparin ELISA. Thromb Haemost 81 (1999) 625-629
13. Warkentin T.E., and Greinacher A. Heparin-induced thrombocytopenia: recognition, treatment, and prevention. Chest 126 (2004) 311S-337S
14. Pouplard C., May M.A., Iocmann S., et al. Antibodies to platelet factor 4 heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin-clinical implications for heparin-induced thrombocytopenia. Circulation 99 (1999) 2530-2536
15. Greinacher A., Michels I., Liebenhoff U., et al. Heparin-associated thrombocytopenia: Immune complexes are attached to the platelet membrane by the negative charge of highly sulphated oligosaccharides. Br J Haematol 84 (1993) 711-716
16. Gruel Y., Pouplard C., Nguyen P., et al., The French Heparin-Induced Thrombocytopenia Study Group. Biological and clinical features of low-molecular-weight heparin-induced thrombocytopenia. Br J Haematol 121 (2003) 786-792
17. Walls J.T., Curtis J.J., Silver D., et al. Heparin-induced thrombocytopenia in open heart surgical patients: Sequelae of late recognition. Ann Thorac Surg 53 (1992) 787-791
18. Gurbuz A.T., Elliott W.G., and Zia A.A. Heparin-induced thrombocytopenia in the cardiovascular patient: Diagnostic and treatment guidelines. Eur J Cardiothorac Surg 27 (2005) 138-149
19. Spiess B.D., Royston D., Levy J.H., et al. Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion 44 (2004) 1143-1148
20. Rice L. Cases of heparin-induced thrombocytopenia elucidate the syndrome. Chest 127 (2005) 21S-26S
21. Williams R.T., Damaraju L.V., Mascelli M.A., et al. Anti-platelet factor 4/heparin antibodies: An independent predictor of 30-day myocardial infarction after acute coronary ischemic syndromes. Circulation 107 (2003) 2307-2313
22. Statis van Eps R., Wester J.P.J., and de Ruiter F.E. The incidence of heparin-induced thrombocytopenia in critically ill patients with the multiple organ dysfunction syndrome (abstract). Thromb Haemost 86 Suppl (2001) P2719
23. Bouman C.S.C., Oudemans-van S.H.M., and Tijssen J.G.P. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure, randomized trial. Crit Care Med 30 (2002) 2205-2211
24. Wester J.P.J., Haas F.J.L., Leusink J.A., et al. Thrombosis and hemorrhage in heparin-induced thrombocytopenia in seriously ill patients. Intensive Care Med 30 (2004) 1927-1934
25. Warkentin T.E., Cook R.J., Marder V.J., et al. Antiplatelet factor 4/heparin antibodies in orthopedic surgery patients receiving antithrombotic prophylaxis with fondaparinux or enoxaparin. Blood 106 (2005) 3791-3796