Fine specificity mapping of autoantigens targeted by anti-centromere autoantibodies

Journal of Autoimmunity

Volumn 27, Issue 4, 2006, Pages 272-280

  Akbarali, Yasmin ^a   Matousek Ronck, Jennifer ^a   Hunt, Laura ^a,b   Staudt, Leslie ^b   Reichlin, Morris ^a   Guthridge, Joel M ^a   James, Judith A ^a,b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Anti centromere autoantibodies; Epitope mapping; Scleroderma

Indexed keywords

ARGININE; AUTOANTIBODY; AUTOANTIGEN; CENTROMERE ANTIBODY; CENTROMERE PROTEIN A; CENTROMERE PROTEIN B; EPITOPE; GLYCINE; PEPTIDE;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATIC DISEASE; SCLERODERMA; SERUM; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; AUTOANTIBODIES; AUTOANTIGENS; CENTROMERE PROTEIN B; CHROMOSOMAL PROTEINS, NON-HISTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; HELA CELLS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SCLERODERMA, LIMITED;

EID: 33846674199     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2006.10.001     Document Type: Article

References (33)

1. Chung L., and Utz P.J. Antibodies in scleroderma: direct pathogenicity and phenotypic associations. Curr Rheumatol Rep 6 (2004) 156-163
2. Moroi Y., Peebles C., Fritzler M.J., Steigerwald J., and Tan E.M. Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl Acad Sci USA 77 (1980) 1627-1631
3. McCarty G.A., Rice J.R., Bembe M.L., and Barada F.A. Anticentromere antibody. Clinical correlations and association with favorable prognosis in patients with scleroderma variants. Arthritis Rheum 26 (1983) 1-7
4. Chan H.L., Lee Y.S., Hong H.S., and Kuo T.T. Anticentromere antibodies (ACA): clinical distribution and disease specificity. Clin Exp Dermatol 19 (1994) 298-302
5. Muro Y., Sugimoto K., Okazaki T., and Ohashi M. The heterogeneity of anticentromere antibodies in immunoblotting analysis. J Rheumatol 17 (1990) 1042-1047
6. Caramaschi P., Biasi D., Manzo T., Carletto A., Poli F., and Bambara L.M. Anticentromere antibody-clinical associations: A study of 44 patients. Rheumatol Int 14 (1995) 253-255
7. Reveille J.D., and Solomon D.H. The American College of Rheumatology AD HOC Committee on Immunologic Testing Guidelines. Evidence-based guidelines for the use of immunologic tests: anticentromere, Scl-70, and nucleolar antibodies. Arthritis Rheum 49 (2003) 399-412
8. Mayes M.D., Lacey Jr. J.V., Beebe-Dimmer J., Gillespie B.W., Cooper B., Laing T.J., et al. Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum 48 (2003) 2246-2255
9. Earnshaw W., Bordwell B., Marino C., and Rothfield N. Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies. J Clin Invest 77 (1986) 426-430
10. Earnshaw W.C., and Rothfield N. Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma. Chromosoma 91 (1985) 313-321
11. Kingwell B., and Rattner J.B. Mammalian kinetochore/centromere composition: A 50 kDa antigen is present in the mammalian kinetochore/centromere. Chromosoma 95 (1987) 403-407
12. Bischoff F.R., Maier G., Tilz G., and Ponstingl H. A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCCI, a gene implicated in onset of chromosome condensation. Proc Natl Acad Sci USA 87 (1990) 8617-8621
13. Rattner J.B., Rees J., Arnett F.C., Reveille J.D., Goldstein R., and Fritzler M.J. The centromere kinesin-like protein, Cenp-E: An autoantigen in systemic sclerosis. Arthritis Rheum 39 (1996) 1355-1361
14. Rattner J.B., Rao A., Fritzler M.J., Valencia D.W., and Yen T. CENP-F is a 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization. Cell Motil Cytoskeleton 26 (1993) 214-226
15. He D., Zeng C., Woods K., Zhong L., Turner D., Busch R.K., et al. CENP-G: a new centromeric protein that is associated with the α-1 satellite DNA subfamily. Chromosoma 107 (1998) 189-197
16. Rothfield N., Whitaker D., Bordwell B., Weiner E., Senecal J.L., and Earnshaw W. Detection of anticentromere antibodies using cloned autoantigen CENP-B. Arthritis Rheum 30 (1987) 1416-1419
17. Earnshaw W.C., Sullivan K.F., Machlin P.S., Cooke C.A., Kaiser D.A., Pollard T.D., et al. Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol 104 (1987) 817-829
18. Verheijen R., de Jong B.A.W., Oberyé E.H.H., and van Venjooij W.J. Molecular cloning of a major CENP-B epitope and its use for the detection of anticentromere antibodies. Mol Biol Rep 16 (1992) 49-59
19. Vázquez-Abad D., Wallace S., Senécal J.L., Joyal F., Roussin A., Earnshaw W.C., et al. Anticentromere antibodies: Evaluation of an ELISA using recombinant fusion protein CENP-B as antigen. Arthritis Rheum 37 (1994) 248-252
20. Russo K., Hoch S., Dima C., Varga J., and Teodorescu M. Circulating anticentromere CENP-A and CENP-B antibodies in patients with diffuse and limited systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. J Rheumatol 27 (2000) 142-148
21. Tan E.M., Smolen J.S., McDougal J.S., Butcher B.T., Conn D., Dawkins R., et al. A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities: 1. Precision, sensitivity, and specificity. Arthritis Rheum 42 (1999) 455-464
22. Dongxu S., Martinez A., Sullivan K.F., Sharp G.C., and Hoch S.O. Detection of anticentromere antibodies using recombinant human CENP-A protein. Arthritis Rheum 39 (1996) 863-867
23. Earnshaw W.C., Machlin P.S., Bordwell B.J., Rothfield N.F., and Cleveland D.W. Analysis of anticentromere antibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci USA 84 (1987) 4979-4983
24. Sugimoto K., Muro Y., and Himeno M. Anti-helix-loop-helix domain antibodies: Discovery of autoantibodies that inhibit DNA binding activity of human centromere protein B (CENP-B). J Biochem 111 (1992) 478-483
25. Muro Y., Sugimoto K., Himeno M., and Ohashi M. The clinical expression in anticentromere antibody-positive patients is not specified by the epitope recognition of CENP-B antigen. J Dermatol 19 (1992) 584-591
26. Muro Y., Iwai T., and Ohashi M. A charged segment mainly composed of basic amino acids forms an autoepitope of CENP-A. Clin Immunol Immunopathol 78 (1996) 86-89
27. Muro Y., Azuma N., Onouchi H., Kunimatsu M., Tomita Y., Sasaki M., et al. Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. Clin Exp Imm 120 (2000) 218-223
28. Mahler M., Mierau R., and Blüthner M. Fine-specificity of the anti-CENP-A B-cell autoimmune response. J Mol Med 78 (2000) 460-467
29. Gonzalez E.N., and Rothfield N.F. Immunoglobulin class and pattern of nuclear fluorescence in systemic lupus erythematosus. N Engl J Med 274 (1966) 1333-1338
30. Arden A., de Groot E.R., and Fletkamp T.E.W. Immunology of DNA III. Crithidia lucilia, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann NY Acad Sci 254 (1975) 505-515
31. Arbuckle M.R., Reichlin M., Harley J.B., and James J.A. Shared early autoantibody recognition events in the development of anti-Sm B/B′ in human lupus. Scand J Immunol 50 (1999) 447-455
32. Sullivan K.F., Hechenberger M., and Masri K. Human CENP-A contains a histone H3 related histone-fold domain that is required for targeting to the centromere. J Cell Biol 127 (1994) 581-592
33. Valdivia M.M., Figueroa J., Iglesias C., and Ortiz M. A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A. FEBS Lett 422 (1998) 5-9