A charged segment mainly composed of basic amino acids forms an autoepitope of CENP-A

Clinical Immunology and Immunopathology

Volumn 78, Issue 1, 1996, Pages 86-89

  Muro, Yoshinao ^a   Iwai, Teruki ^a   Ohashi, Masaru ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; EPITOPE; SYNTHETIC PEPTIDE;

ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ETIOLOGY; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCLERODERMA;

EID: 0029981776     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1996.0013     Document Type: Article

References (30)

1. Tan, E. M., Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv. Immunol. 44, 93-151, 1989.
2. Muro, Y., Sugimoto, K., Okazaki, T., and Ohashi, M., The heterogeneity of anticentromere antibodies in immunoblotting analysis. J. Rheumatol. 17, 1042-1047, 1990.
3. Earnshaw, W., Bordwell, B., Marino, C., and Rothfield, N., Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies. J. Clin. Invest. 77, 426-430, 1986.
4. Earnshaw, W. C., Sullivan, K. F., Machlin, P. S., Cooke, C. A., Kaiser, D. A., Pollard, T. D., Rothfield, N. F., and Cleveland, D. W., Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J. Cell Biol. 104, 817-829, 1987.
5. Sullivan, K. F., and Glass, C. A., CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins. Chromosoma 100, 360-370, 1991.
6. Masumoto, H., Masukata, H., Muro, Y., Nozaki, N., and Okazaki, T., A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite. J. Cell Biol. 109, 1963-1973, 1989.
7. Muro, Y., Masumoto, H., Yoda, K., Nozaki, N., Ohashi, M., and Okazaki, T., Centromere protein B assembles human centromeric α-satellite DNA at the 17-bp sequence, CENP-B box. J. Cell Biol. 116, 585-596, 1992.
8. Pluta, A. F., Saitoh, N., Goldberg, I., and Earnshaw, W. C., Identification of a subdomain of CENP-B that is necessary and sufficient for localization to the human centromere. J. Cell Biol. 116, 1081-1093, 1992.
9. Sugimoto, K., Muro, Y., and Himeno, M., Anti-helix-loop-helix domain antibodies: Discovery of autoantibodies that inhibit DNA binding activity of human centromere protein B (CENP-B). J. Biochem. 111, 478-483, 1992.
10. 2 terminus, which is separable from dimerizing activity. J. Cell Biol. 119, 1413-1427, 1992.
11. Earnshaw, W. C., Machlin, P. S., Bordwell, B. J., Rothfield, N. F., and Cleveland, D. W., Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc. Natl. Acad. Sci. USA 84, 4979-4983, 1987.
12. Rothfield, N., Whitaker, B., Bordwell, B., Weiner, E., Senecal, J.-L., and Earnshaw, W., Detection of anticentromere antibodies using cloned autoantigen CENP-B. Arthritis Rheum. 30, 1416-1419, 1987.
13. Muro, Y., Masumoto, H., Okazaki, T., and Ohashi, M., Purification of a human centromere antigen (CENP-B) and application of DNA immunoprecipitation to quantitative assay for anti-CENP-B antibodies. J. Invest. Dermatol. 97, 378-380, 1991.
14. Muro, Y., Matsumoto, Y., and Ohashi, M., Anticentromere-protein-B-DNA complex activities in anticentromere antibody-positive patients. Arch. Dermatol. Res. 284, 396-399, 1992.
15. Sugimoto, K., Migita, H., Hagishita, Y., Yata, H., and Himeno, M., An antigenic determinant on human centromere protein B (CENP-B) available for production of human-specific anticentromere antibodies in mouse. Cell Struct. Fund. 17, 129-138, 1992.
16. Muro, Y., Sugimoto, K., Himeno, M., and Ohashi, M., The clinical expression in anticentromere antibody-positive patients is not specified by the epitope recognition of CENP-B antigen. J. Dermatol. 19, 584-591, 1992.
17. Verheijen, R., de Jong, B. A. W., Oberye, E. H. H., and van Venrooij, W. J., Molecular cloning of a major CENP-B epitope and its use for the detection of anticentromere autoantibodies. Mol. Biol. Rep. 16, 49-59, 1992.
18. Sullivan, K. F., Hechenberger, M., and Masri, K., Human CENP-A contains a histone H3 related histone fold domain that is required for targetting to the centromere. J. Cell Biol. 127, 581-592, 1994.
19. Elkon, K. B., Use of synthetic peptides for the detection and quantification of autoantibodies. Mol. Biol. Rep. 16, 207-212, 1992.
20. Tan, E. M., Muro, Y., and Pollard, K. M., Autoantibody-defined epitopes on nuclear antigens are conserved, conformation-dependent and active site regions. Clin. Exp. Rheum. 12(Suppl. 11), S27-S31, 1994.
21. Muro, Y., Tsai, W.-M., Houghten, R., and Tan, E. M., Synthetic compound peptide simulating antigenicity of conformation-dependent autoepitope. J. Biol. Chem. 269, 18529-18534, 1994.
22. Houghten, R. A., General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA 82, 5131-5135, 1985.
23. Appel, J. R., Pinilla, C., Niman, H., and Houghten, R. A., Elucidation of discontinuous linear determinants in peptides. J. Immunol. 144, 976-983, 1990.
24. Elkon, K. B., Hines, J. J., Chu, J. L., and Parnassa, A. P., Epitope mapping of recombinant HeLa SmB and B′ peptides obtained by the polymerase reaction. J. Immunol. 145, 636-643, 1990.
25. Bini, P., Chu, J. L., Okolo, C., and Elkon, K. B., Analysis of autoantibodies to recombinant La (SS-B) peptides in systemic lupus erythematosus and primary Sjogren's syndrome. J. Clin. Invest. 85, 325-333, 1990.
26. Brendel, V., Dohlman, J., Blaisdell, B. E., and Karlin, S., Very long charge runs in systemic lupus erythematosus-associated autoantigens. Proc. Natl. Acad. Sci. USA 88, 1536-1540, 1991.
27. Billings, P. B., Martinenz, A., Haselby, J. A., and Hoch, S. O., Protein blot assays specific for the discrimination of the centromere autoantigen, CENP-A, from human cells. Electrophoresis 14, 909-916, 1993.
28. Hoch, S. O., The Sm antigen. In "Manual of Biological Markers of Disease" (W. J., van Venrooij and R. N., Maini, Eds.), pp. B2.4: 1-29, Kluwer Academic, Dordrecht, 1994.
29. Netter, H. J., Will, H., Szostecki, C., and Guldner, H. H., Repetitive p68-autoantigen specific epitopes recognized by human anti-(U1) small nuclear ribonucleoprotein autoantibodies. J. Autoimmunity 4, 651-663, 1991.
30. Muro, Y., and Tan, E. M., PCNA. In "Manual of Biological Markers of Disease" (W. J. van Venrooij and R. N. Maini, Eds.), pp. B2.7: 1-12, Kluwer Academic, Dordrecht, 1994.