Whey pretreatment ameliorates gastric and hepatic oxidative damage in ethanol-induced gastric ulcer via a neutrophil-dependent mechanism

Marmara Medical Journal

Volumn 18, Issue 2, 2005, Pages 64-70

  Jahovic, Nermina ^a   Öǧünç, Ayliz Velioǧlu ^a   Güzel, Esra ^a   Ars, Derya ^a   Ercan, Feriha ^a   Erkanli, Gözde ^a   Yeǧen, Berrak Ç ^a   Yalçin, A Süha ^a,b  

^a MARMARA UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Ethanol; Gastric and hepatic oxidative damage; Whey proteins

Indexed keywords

ALCOHOL; FREE RADICAL; MALONALDEHYDE; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; LIPID PEROXIDATION; LIVER INJURY; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; RAT; STOMACH INJURY; STOMACH ULCER; WHEY;

EID: 33846658058     PISSN: 10191941     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Alphin RS, Vokac VA, Gregory RL, Bolton PM, Tawes JW. Role of intragastric pressure, pH, and pepsin in gastric ulceration in the rat. Gastroenterology 1977; 73: 495-500.
2. Brooks FP. The pathophysiology of peptic ulcer disease. Dig Dis Sci 1985; 30: 15s-29s.
3. Grossman MI. Peptic ulcer: the pathophysiological background. Scand J Gastroenterology 1980; 15 (Suppl. 58): 7-15.
4. Eastwood GL, Kirchner JP. Changes in the fine structure of mouse gastric epithelium produced by ethanol and urea. Gastroenterology 1974; 67: 71-84.
5. Szabo S. Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol 1987; 127 (suppl): 21-28.
6. Pihan G, Regilo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987; 32: 1395-1401.
7. Kim J-H, Choi S-K, Choi S-Y, Kim H-K, Chang H-I. Suppressive effect of astaxanthin isolated from the xanthophyllomyces dendrorhous mutant on ethanol-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem 2005; 69: 1300-1305.
8. Etzel MR. Manufacture and use of dairy protein fractions. J Nutr 2004; 134: 996-1002.
9. Marshall K. Therapeutic applications of whey protein. Altern Med Rev 2004; 9: 136-156.
10. Yalcin AS. Emerging therapeutic properties of whey proteins and peptides. Curr Pharm Des 2006; 12: 1637-1643.
11. Bounous G, Letourneau L, Kongshavn PAL. Influence of dietary protein type on the immune system of mice. J Nutr 1983; 113: 1415-1421.
12. Bounous G, Gold P. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med 1991; 14: 296-309.
13. Rosaneli CF, Bigheti AE, Antonio MA, Carvalho JE, Sgarbieri VC. Efficacy of a whey protein concentrate on the inhibition of stomach ulcerative lesions caused by ethanol ingestion. J Med Food 2002; 5: 221-228.
14. Matsuda H, Pongpiriyadacha Y, Morikawa T, Kashima Y, Nakano K, Yoshikawa M. Protective effects of polygoidal and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg Med Chem Lett 2002; 12: 477-482.
15. Buege JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 53: 302-311.
16. Hillegass LM, Griswold DE, Brickson B, Albrightson-Winslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth 1990; 24: 285-295.
17. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide production. J Clin Invest 1993; 91: 2546-2551.
18. Davies GR, Simmond NJ, Stevens TRJ, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994; 35: 179-185.
19. Haklar G, Yüksel M, Yalcin AS. Chemiluminescence in the measurement of free radicals: theory and application on a tissue injury model. Marmara Med J 1998; 11: 56-60.
20. Bounous G, Molson J. The antioxidant system. Anticancer Res 2003; 23: 1411-1415.
21. Bafna PA, Balaraman R. Anti-ulcer and anti-oxidant activity of Pepticare, a herbomineral formulation. Phytomedicine 2005; 12: 264-270.
22. Repetto MG, Llesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 2002; 35: 523-534.
23. Piotrowski J, Piotrowski E, Skrodzka D, Slomiany A, Slomiany BL. Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents. Biochem Molec Biol Int 1997; 42: 247-254.
24. Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 2003; 278: 10933-11001.
25. Korhonen HJ, Reiter B. Production of H2O2 by bovine blood and milk polymorphonuclear leucocytes. Acta Microbiol Pol 1983; 32: 53-64.
26. Bartfay WJ, Davis MT, Medves JM, Lugowski S. Milk whey protein decreases oxygen free radical production in a murine model of chronic iron-overload cardiomyopathy. Can J Cardiol 2003; 19: 1163-1168.
27. Hiraishi H, Shimada T, Ivey KJ, Terano A. Role of antioxidant defenses against ethanol-induced damage in cultured rat gastric epithelial cells. J Pharmacol Exp Ther 1999; 289: 103-109.
28. Dial EJ, Lichtenberger LM. Milk protection against experimental ulcerogenesis in rats. Dig Dis Sci 1987; 32: 1145-1150.
29. Kivinen A, Salminen S, Homer D, Vapaatalo H. Gastroprotective effect of milk phospholipids, butter serum lipids and butter serum on ethanol and acetylsalicylic acid induced ulcers in rats. Milchwissenschaft 1992; 47: 573-575.
30. Koo MW. The effects of milk and calcium on ethanol-induced gastric mucosal damage. Pharmacol Res 1994; 29: 217-224.
31. Matsumoto H, Shimokawa Y, Ushida Y, Toida T, Hayasawa H. New biological function of bovine alpha-lactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem 2001; 65: 1104-1111.
32. Clarke J, Butler R, Howarth G, Read L, Regester G. Exposure of oral mucosa to bioactive milk factors reduces severity of chemotherapy-induced mucositis in the hamster. Oral Oncol 2002; 38: 478-485.
33. Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia-reperfusion induced granulocyte infiltration. Amer J Physiol 1990; 258: G185-G190.
34. Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leuk Biol 2000; 67: 591-602.
35. Kettle AJ, Winterbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Report 1997; 3: 3-15.