Human epidermoid A431 cells express functional nicotinic Acid receptor HM74a

Molecular and Cellular Biochemistry

Volumn 294, Issue 1-2, 2007, Pages 243-248

  Zhou, Lubing ^a,b   Tang, Yuting ^a   Cryan, Ellen V ^a   Demarest, Keith T ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b NONE   (United States)

Author keywords

A431 cell line; G protein coupled receptor; HM74a; Nicotinic acid (niacin)

Indexed keywords

CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; NICOTINIC ACID; PERTUSSIS TOXIN;

ADIPOCYTE; ADIPOSE TISSUE; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CARCINOMA CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FLUSHING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROADIPOCYTE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA SEQUENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

AMINO ACID SEQUENCE; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CYCLIC AMP; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; RNA, MESSENGER;

EID: 33846655317     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9150-6     Document Type: Article

References (17)

1. Szapary PO, Rader DJ: Pharmacological management of high triglycerides and low high-density lipoprotein cholesterol. Curr Opin Pharmacol 1: 113-120, 2001
2. Tavintharan S, Kashyap ML: The benefits of niacin in atherosclerosis. Curr Atherosclerosis Rep 3(1): 74-82, 2001
3. Rosenhamer G, Carlson LA: Effect of combined clofibrate-nicotinic acid treatment in ischemic heart disease. Atherosclerosis 37: 129-142, 1980
4. Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S: PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med 9: 352-355, 2003
5. Aktories K, Jakobs KH, Schultz G: Nicotinic acid inhibits adipocyte adenylate cyclase in a hormone-like manner. FEBS Lett 115: 11-14, 1980
6. Soga T, Kamohara M, Takasaki J, Matsumoto S-i, Saito T, Ohishi T, Hiyama H, Matsuo A, Matsushime H, Furuichi K: Molecular identification of nicotinic acid receptor. Biochem Biophys Res Commun 303: 364-369, 2003
7. Wise A, Foord Steven M, Fraser Neil J, Barnes Ashley A, Elshourbagy N, Eilert M, Ignar Diane M, Murdock Paul R, Steplewski K, Green A, Brown Andrew J, Dowell Simon J, Szekeres Philip G, Hassall David G, Marshall Fiona H, Wilson S, Pike Nicholas B: Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem 278: 9869-9874, 2003
8. Benyo Z, Gille A, Kero J, Csiky M, Suchankova MC, Nuesing RM, Moers A, Pfeffer K, Offermanns S: GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. J Clin Invest 115: 3634-3640, 2005
9. Heid CA, Stevens J, Livak KJ, Williams PM: Real time quantitative PCR. Genome Res 6: 986-994, 1996
10. Lorenzen A, Stannek C, Lang H, Andrianov V, Kalvinsh I, Schwabe U: Characterization of a G protein-coupled receptor for nicotinic acid. Mol Pharmacol 59: 349-357, 2001
11. Watts VJ: Molecular mechanisms for heterologous sensitization of adenylate cyclase. J Pharmacol Eexp Therap 302: 1-7, 2002
12. Rubic T, Trottmann M, Lorenz RL: Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol 67: 411-419, 2004
13. Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersey JH, Dosik H, Parks WP: In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 51: 1417-1423, 1973
14. Mahley RW, Bersot TP: Drug therapy for hypercholesterolemia and dyslipidemia. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th ed, McGraw-Hill, New York, pp 971-1002, 2002
15. Morrow JD, Awad JA, Oates JA, Roberts LJ: Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J Invest Dermatol 98: 812-815, 1992
16. Stern RH, Spence JD, Freeman DJ, Parbtani A: Tolerance to nicotinic acid flushing. Clin Pharmacol Therap 50: 66-70, 1991
17. Sun GY, Xu J, Jensen MD, Yu S, Wood WG, Gonzalez FA, Simonyi A, Sun AY, Weisman GA: Phospholipase A2 in astrocytes. Responses to oxidative stress, inflammation, and G protein-coupled receptor agonists. Mol Neurobiol 31: 27-41, 2005