A plasminogen-activating protease specifically controls the development of primary pneumonic plague

Science

Volumn 315, Issue 5811, 2007, Pages 509-513

  Lathem, Wyndham W ^a   Price, Paul A ^a   Miller, Virginia L ^a   Goldman, William E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIAL DISEASE; BACTERIUM; ENZYME ACTIVITY; PNEUMONIA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE TRANSMISSION; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; MORTALITY; MOUSE; NONHUMAN; PLAGUE; PLASMINOGEN ACTIVATION; PNEUMONIA; PRIORITY JOURNAL; SURVIVAL; YERSINIA PESTIS;

ANIMALS; CELL PROLIFERATION; COLONY COUNT, MICROBIAL; CYTOKINES; FEMALE; FIBRINOGEN; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, BACTERIAL; LUNG; MICE; MICE, INBRED C57BL; MUTATION; PLAGUE; PLASMINOGEN; PLASMINOGEN ACTIVATORS; PNEUMONIA, BACTERIAL; SPLEEN; TETRACYCLINES; VIRULENCE FACTORS; YERSINIA PESTIS;

ANIMALIA; YERSINIA PESTIS;

EID: 33846645905     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1137195     Document Type: Article

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23. We thank K. Wright, J. Fischer, and J. Vogel for helpful discussions; J. Hinnebusch for the Y. pestis antibody; and the Washington University Digestive Diseases Research Core (DDRCC) for histological sections. This work was supported by NIH grant U54-AI057160 Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research (MRCE) and by NIH grant AI53298. The DDRCC is supported by NIH grant DK52574. W.W.L. was supported by the Clinical/Translational Fellowship Program of the MRCE, the W.M. Keck Foundation, and the NIH National Research Service Award (NRSA) F32 AI069688-01. P.A.P. was supported by the NIH Institutional NRSA T32 GM07067 to the Washington University School of Medicine.