Nuclear imaging of vulnerable plaque: Contrast improvements through multi-labeling of nanoparticles

IEEE Nuclear Science Symposium Conference Record

Volumn 3, Issue , 2005, Pages 1681-1685

  Wagenaar, Douglas J ^a,b   Chen, Jason A ^c  

^a SIEMENS CORPORATE RESEARCH   (United States)

^b Ideas Inc   (United States)

^c ILLINOIS MATHEMATICS AND SCIENCE ACADEMY   (United States)

Author keywords

Contrast to noise ratio; Multi labeling; Nuclear medicine

Indexed keywords

CARDIOVASCULAR SYSTEM; COMPUTER SIMULATION; DISEASES; IMAGE QUALITY; NANOSTRUCTURED MATERIALS; NUCLEAR MEDICINE; PATIENT TREATMENT;

CONTRAST IMPROVEMENTS; CONTRAST-TO-NOISE RATIO (CNR); MULTI LABELING; NUCLEAR IMAGING;

MEDICAL IMAGING;

EID: 33846645891     PISSN: 10957863     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/NSSMIC.2005.1596643     Document Type: Conference Paper

References (18)

1. E. Falk, P. K. Shah, and V. Fuster, "Coronary plaque disruption," Circulation, vol. 92, pp. 657-671, 1995.
2. V. Fuster, L. Badimon, J. J. Badimon, and J. H. Chesebro, "The pathogenesis of coronary artery disease and the acute coronary syndromes," New England Journal of Medicine, vol. 326, pp. 242-250, 1992.
3. J. Narula and L. Hofstra, "Imaging myocardial necrosis and apoptosis," in Atlas of Nuclear Cardiology, V. Dilsizian and J. Narula, Eds. Philadelphia, PA: Current Medicine, 2003, pp. 197-216.
4. J. Shin, J. E. Edelberg, and M. K. Hong, "Vulnerable Atherosclerotic Plaque: Clinical Implications," Current Vascular Pharmacology, vol. 1, pp.183-204, 2003.
5. J. Narula, "Nuclear Imaging of Vulnerable Atherosclerotic Lesions," In 2004 SNM Mid-Winter Educational Symposium, 2004.
6. H. W. Strauss, M. Dunphy, and N. Tokita, "Imaging the Vulnerable Plaque: A Scintillating Light at the End of the Tunnel?" Journal of Nuclear Medicine, vol. 45, pp. 1106-1107, 2004.
7. F. A. Jaffer and R. Weissleder, "Molecular Imaging in the Clinical Arena," The Journal of the American Medical Association, vol. 293, pp. 855-862, 2005.
8. J. R. Davies, J. H. Rudd, and P. L. Weissberg, "Molecular and Metabolic Imaging of Atherosclerosis," Journal of Nuclear Medicine, vol. 45, pp. 1898-1907, 2004.
9. S. R. Cherry, J. A. Sorenson, and M. E. Phelps, Physics in Nuclear Medicine. Philadelphia, PA: Elsevier Science, 2003.
10. S. H. Britz-Cunningham and S. J. Adelstein, "Molecular Targeting with Radionuclides: State of the Science," Journal of Nuclear Medicine, vol. 44, pp.1945-1961, 2004.
11. D. J. Wagenaar and J. A. Chen, "Signal amplification in molecular imaging using nanoparticles," US Patent Application, Siemens Medical Solutions USA, Inc., September 2005.
12. S. A. Wickline and G. M. Lanza, "Nanotechnology for molecular imaging and targeted therapeutics," Circulation, vol. 107, pp. 1092-1095, 2003.
13. 3-integrin-targeted nanoparticles," Circulation, vol. 108, pp. 2270-2274, 2003.
14. D. E. Sosnovik, E. A. Schellenberger, M. Nahrendorf, M. S. Novikov, T. Matsui, G. Dai, F. Reynolds, L. Grazette, A. Rosenzweig, R. Weissleder, and L. Josephson, "Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle," Magnetic Resonance Medicine, vol. 54, pp. 718-724, 2005.
15. T. F. Massoud and S. S. Gambhir, "Molecular imaging in living subjects: seeing fundamental biological processes in a new light," Genes & Development, vol. 17, pp. 545-580, 2003.
16. st Annual Meeting, 2004, p. 454P.
17. Research Systems, Inc. Using IDL: Research Systems User's Manual, Boulder, CO: 2003.
18. Siemens Medical Solutions, Inc., e.soft™ 5.0, Hoffman Estates, IL, 2006.