A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Journal of Bacteriology

Volumn 189, Issue 3, 2007, Pages 844-850

  Kitada, Sakae ^a   Uchiyama, Tsuneo ^b   Funatsu, Tomoyuki ^a   Kitada, Yumiko ^a   Ogishima, Tadashi ^a   Ito, Akio ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA MITOCHONDRIAL PROCESSING PEPTIDASE; BACTERIAL PROTEIN; BETA MITOCHONDRIAL PROCESSING PEPTIDASE; GLYCINE; MITOCHONDRIAL PROTEIN; PROTEIN PRECURSOR; RICKETTSIAL PUTATIVE PEPTIDASE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME ACTIVITY; HYDROLYSIS; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; RICKETTSIA PROWAZEKII; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; KINETICS; METALLOENDOPEPTIDASES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDES; PHYLOGENY; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; RICKETTSIA PROWAZEKII; SEQUENCE ALIGNMENT;

RICKETTSIA PROWAZEKII; RICKETTSIACEAE;

EID: 33846625139     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01261-06     Document Type: Article

References (31)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Andersson, S. G., A. Zomorodipour, J. O. Andersson, T. Sicheritz-Ponten, U. C. Alsmark, R. M. Podowski, A. K. Naslund, A. S. Eriksson, H. H. Winkler, and C. G. Kurland. 1998. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396:133-140.
3. Baker, K. P., and G. Shatz. 1991. Mitochondrial proteins essential for viability mediate protein import into yeast mitochondria. Nature 349:205-208.
4. Bolhuis, A., E. Koetje, J.-Y. Dubois, J. Vehmaanper, G. Venema, S. Bron, and J. M. van Dijl. 2000. Did the mitochondrial processing peptidase evolve from a eubacterial regulator of gene expression? Mol. Biol. Evol. 17:198-201.
5. Chen, N. Y., S. Q. Jiang, D. A. Klein, and H. Paulus. 1993. Organization and nucleotide sequence of the Bacillus subtilis diaminopimelate operon, a cluster of genes encoding the first three enzymes of diaminopimelate synthesis and dipicolinate synthase. J. Biol. Chem. 268:9448-9465.
6. Dolezal, P., O. Smid, P. Rada, Z. Zubacova, D. Bursac, R. Sutak, J. Nebesarova, T. Lithgow, and J. Tachezy. 2006. Giardia mitosomes and trichomonad hydrogenosomes share a common mode of protein targeting. Proc. Natl. Acad. Sci. USA 102:10924-10929.
7. Doolittle, W. F. 1998. A paradigm gets shifty. Nature 392:15-16.
8. Dyall, S. D., M. T. Brown, and P. J. Johnson. 2004. Ancient invasions: from endosymbionts to organelles. Science 304:253-257.
9. Emelyanov, V. V. 2001. Evolutionary relationship of Rickettsiae and mitochondria. FEBS Lett. 501:11-18.
10. Gakh, O., P. Cavadini, and G. Isaya. 2002. Mitochondrial processing peptidases. Biochim. Biophys. Acta 1592:63-77.
11. Gray, M. W., G. Burger, and B. F. Lang. 1999. Mitochondrial evolution. Science 283:1476-1481.
12. Hartl, F.-U., N. Pfanner, D. W. Nicholson, and W. Neupert. 1989. Mitochondrial protein import. Biochim. Biophys. Acta 988:1-45.
13. Ito, A. 1999. Mitochondrial processing peptidase: multiple-site recognition of precursor proteins. Biochem. Biophys. Res. Commun. 265:611-616.
14. Kitada, S., K. Shimokata, T. Niidome, T. Ogishima, and A. Ito. 1995. A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity. J. Biochem. 117:1148-1150.
15. Kitada, S., K. Kojima, K. Shimokata, T. Ogishima, and A. Ito. 1998. Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase. J. Biol. Chem. 273:32547-32553.
16. Luciano, P., and V. Geli. 1996. The mitochondrial processing peptidase: function and specificity. Experientia 52:1077-1082.
17. Margulis, L. 1996. Archaeal-eubacterial mergers in the origin of Eukarya: phylogenetic classification of life. Proc. Natl. Acad. Sci. USA 93:1071-1076.
18. McLeod, M. P., X. Qin, S. E. Karpathy, J. Gioia, S. K. Highlander, G. E. Fox, T. Z. McNeill, H. Jiang, D. Muzny, L. S. Jacob, A. C. Hawes, E. Sodergren, R. Gill, J. Hume, M. Morgan, G. Fan, A. G. Amin, R. A. Gibbs, C. Hong, X. J. Yu, D. H. Walker, and G. M. Weinstock. 2004. Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae. J. Bacteriol. 186:5842-5855.
19. Nagao, Y., S. Kitada, K. Kojima, H. Toh, S. Kuhara, T. Ogishima, and A. Ito. 1998. Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins. J. Biol. Chem. 275:34552-34556.
20. Neupert, W. 1997. Protein import into mitochondria. Annu. Rev. Biochem. 66:863-917.
21. Niidome, T., S. Kitada, K. Shimokata, T. Ogishima, and A, Ito. 1994. Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. J. Biol. Chem. 269:24719-24722.
22. Nomura, H., S. Athauda, H. Wada, Y. Maruyama, K. Takahashi, and H. Inoue. 2006. Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of cytochrome bc1 complex of Caenorhabditis elegans, a model organism of parasitic nematodes. J. Biochem. 139:967-979.
23. Ogata, H., S. Audic, P. Renesto-Audiffren, P. E. Fournier, V. Barbe, S. Samson, V. Roux, P. Cossart, J. Weissenbach, J. M. Claverie, and D. Raoult. 2001. Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science 293:2093-2098.
24. Pfanner, N., E. A. Craig, and A. Hönlinger. 1997. Mitochondrial preprotein translocase. Annu. Rev. Cell Dev. Biol. 13:25-51.
25. Rawlings, N., and A. J. Barrett. 1995. Evolutionary families of metallopeptidases. Methods Enzymol. 248:183-228.
26. Ryan, K. R., and R. E. Jensen. 1995. Protein translocation across mitochondrial membranes: what a long, strange trip it is. Cell 83:517-519.
27. Schatz, G. 1996. The protein import system of mitochondria. J. Biol. Chem. 271:31763-31766.
28. Taylor, A. B., B. S. Smith, S. Kitada, K. Kojima, H. Miyaura, Z. Otwinowski, A. Ito, and J. Deisenhofer. 2001. Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences. Structure 9:615-625.
29. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
30. Yaffe, M. P., S. Ohta, and G. Schatz. 1985. A yeast mutant temperature-sensitive for mitochondrial assembly is deficient in a mitochondrial protease activity that cleaves imported precursor polypeptides. EMBO J. 4:2069-2074.
31. Yan, Y., T. Uchiyama, and T. Uchida. 1993. Differentiation of Rickettsia japonica by restriction endonuclease fragment length polymorphism using products of polymerase chain reaction amplification with Rickettsia rickettsii 190-kilodalton surface antigen gene primers. Microbiol. Immunol. 37:441-445.