Glutamate-independent calcium toxicity: Introduction

Stroke

Volumn 38, Issue 2 PART 2, 2007, Pages 661-664

  Annunziato, Lucio ^a,b   Cataldi, Mauro ^a   Pignataro, Giuseppe ^a   Secondo, Agnese ^a   Molinaro, Pasquale ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; PSALMOTOXIN 1; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL BLOCKING AGENT; SPIDER VENOM; TOXIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

APOPTOSIS; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG TARGETING; ENZYME ACTIVATION; EXCITOTOXICITY; GENETIC TRANSCRIPTION; GLYCOLYSIS; HUMAN; MICROTUBULE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SODIUM CELL LEVEL; SODIUM CURRENT; SODIUM TRANSPORT; STROKE; TRAUMATIC BRAIN INJURY;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CELL HYPOXIA; GLUTAMIC ACID; HUMANS;

EID: 33846623346     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000247942.42349.37     Document Type: Conference Paper

References (17)

1. Syntichaki P, Tavernarakis N. The biochemistry of neuronal necrosis: Rogue biology? Nat Rev Neurosci. 2003;4:672-684.
2. Olney JW, Ho OL, Rhee V, DeGubareff T. Letter: Neurotoxic effects of glutamate. N Engl J Med. 1973;289:1374-1375.
3. Choi DW, Koh JY, Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J Neurosci. 1988;8:185-196.
4. Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol. 2002;1:383-386.
5. Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 2004;118:687-698.
6. Pignataro G, Gala R, Cuomo O, Tortiglione A, Giaccio L, Castaldo P, Sirabella R, Matrone C, Canitano A, Amoroso S, Di Renzo G, Annunziato L. Two Sodium/Calcium Exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke. 2004;35:2566-2570.
7. Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell. 2003;115:863-877.
8. 2+ signaling, cell death and stroke. Trends Neurosci. 2006;29:75-81.
9. Xiong ZG, Chu XP, Simon RP. Ca(2+)-permeable acid-sensing ion channels and ischemic brain injury. J Membr Biol. 2006;209:59-68.
10. 2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol Rev. 2004;56:633-654.
11. 2+ exchanger (NCX1, NCX2, NCX3). Am J Physiol. 1998;274:C415-C423.
12. 2+ exchanger-encoding genes NCX1, NCX2, and NCX3 and their related proteins in the central nervous system. Ann N Y Acad Sci. 2002;976:394-404.
13. 2+ exchanger isoform 3 (NCX3), but not of NCX2 and NCX1, plays a protective role in a model of chemical hypoxia. Abstract of 35th Annual Meeting the Society for Neuroscience. Washington DC, 2005; Abstract 550.18.
14. Boscia F, Gala R, Pignataro G, de Bartolomeis A, Cicale M, Ambesi-Impiombato A, Di Renzo G, Annunziato L. Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na(+)/Ca(2+) exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions. J Cereb Blood Flow Metab. 2006;26:502-517.
15. Hossmann KA. Periinfarct depolarizations. Cerebrovasc Brain Metab Rev. 1996;8:195-208.
16. 2+ exchanger in excitotoxicity. Cell. 2005;120:275-285.
17. 2 levels of gerbil hippocampus. Neurosci Res. 1992;15:305-309.