The Steroid Withdrawal Syndrome: A Review of the Implications, Etiology, and Treatments

Journal of Pain and Symptom Management

Volumn 33, Issue 2, 2007, Pages 224-228

  Margolin, Leon ^a   Cope, Doris K ^a   Bakst Sisser, Rachel ^a   Greenspan, Joshua ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

high fever; palliative medicine; Steroid withdrawal syndrome

Indexed keywords

CHLORAMPHENICOL; DEXAMETHASONE; HYDROCORTISONE; PREDNISONE; STEROID; TETRACOSACTIDE ZINC PHOSPHATE;

ABDOMINAL PAIN; ADULT; ANOREXIA; ARTHRALGIA; ARTHRITIS; ARTICLE; BREAST CANCER; BURSITIS; CASE REPORT; CHRONIC PAIN; COLON RESECTION; CRANIOTOMY; DESQUAMATION; DRUG DOSE REDUCTION; DRUG FEVER; DRUG WITHDRAWAL; FEMALE; FEVER; HEADACHE; HUMAN; HYPOTENSION; LETHARGY; MALE; MYALGIA; NAUSEA; SIDE EFFECT; STEROID THERAPY; STEROID WITHDRAWAL SYNDROME; SWEATING; ULCERATIVE COLITIS; VOMITING; WEIGHT REDUCTION; WITHDRAWAL SYNDROME;

ADULT; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN; PALLIATIVE CARE; STEROIDS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 33846614554     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2006.08.013     Document Type: Article

References (20)

1. Saracco P., Bertorello N., Faarinasso L., et al. Steroid withdrawal syndrome during steroid tapering in childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 27 3 (2005) 141-144
2. Skanse B., Gydell K., Wulff H.B., et al. Cushing's syndrome and its response to adrenalectomy. Acta Med Scand 154 (1956) 119-134
3. Slocumb C.H. Rheumatic complaints during chronic hypercortisonism and syndromes during withdrawal of cortisone in rheumatic patients. Proc Staff Mett Mayo Clinic 28 (1953) 655-657
4. Amatruda T.T., Hollingsworth D., D'esopo N.D., et al. A study of the mechanism of the steroid withdrawal syndrome. Evidence for integrity of the hypothalamic-pituitary-adrenal system. J Clin Endocrinol Metab 20 (1960) 339-354
5. Amatruda T.T., Hurst M.M., and D'esopo N.D. Certain endocrine and metabolic facets of the steroid withdrawal syndrome. J Clin Endocrinol Metab 25 9 (1965) 1207-1217
6. Henneman P.H., Wang D.M., Irwin J.W., and Burrage W.S. Syndrome following abrupt cessation of prolonged cortisone therapy. JAMA 158 5 (1955) 384-386
7. Calkins E., Engel L.L., et al. Clinical, metabolic and endocrinologic effects of abrupt cessation of maintenance cortisone acetate therapy in rheumatoid arthritis. Arthritis Rheum 3 (1960) 204-217
8. Spellberg M.A. Postcolectomy syndrome with fever and abdominal pain simulating acute abdominal inflammation caused by steroid withdrawal. Am J Gastroenterol 46 (1966) 214-221
9. Margolin L., Bakst-Sisser R., Segal M., et al. High fever induced by prednisone withdrawal. Clin Drug Invest 24 (2004) 689-691
10. Farrell G.L., and Laqueur G. Reduction of pituitary content of ACTH by cortisone. Endocrinology 56 4 (1955) 471-473
11. Salassa R.M., Bennett W.A., Keating Jr. F.R., and Sprague R.G. Postoperative adrenal cortical insufficiency: occurrence in patients previously treated with cortisone. JAMA 152 16 (1953) 1509-1515
12. Kyle L.H., Meyer R.J., and Canary J.J. Mechanism of adrenal atrophy in Cushing's syndrome due to adrenal tumor. N Engl J Med 257 2 (1957) 57-61
13. Sandberg A.A., Eik-Nes K., Migeon C.J., and Koepf G.F. Plasma 17-hydroxycorticosteroids in hyperfunction, suppression, and deficiency of adrenal cortical function. J Lab Clin Med 50 2 (1957) 286-296
14. Gryglewski R.J., Panczenko B., Korbut R., Grodzinska L., and Ocetkiewicz A. Corticosteroids inhibit prostaglandin release from perfused lungs of sensitized guinea pig. Prostaglandins 10 2 (1975) 343-355
15. Blackwell G.J., and Flower R.J. Glucocorticoids, lungs and prostaglandins. Bull Eur Physiopathol Respir 17 4 (1981) 595-607
16. Bergstrom S., Carlson L.A., and Weeks J.R. The prostaglandins: a family of biologically active compounds. Pharmacol Rev 20 1 (1968) 1-48
17. Vane J.R. Prostaglandins as mediators of inflammation. Adv Prostaglandin Thromboxane Res 2 (1976) 791-801
18. Behrman H.R., and Anderson G.G. Prostaglandins in reproduction. Arch Intern Med 133 1 (1974) 77-84
19. Milton A.S., and Wendlandt S. Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits. J Physiol 218 2 (1971) 325-336
20. Papanicolaou D.A., Tsigos C., Oldfield E.H., and Chrousos G.P. Acute glucocorticoid deficiency is associated with plasma elevations of interleukin-6: does the latter participate in the symptomatology of the steroid withdrawal syndrome and adrenal insufficiency?. J Clin Endocrinol Metab 81 6 (1996) 2303-2306