Bubble growth within the skin by rectified diffusion might play a significant role in sonophoresis

Journal of Controlled Release

Volumn 117, Issue 2, 2007, Pages 246-255

  Lavon, Ilana ^a   Grossman, Nili ^b   Kost, Joseph ^a   Kimmel, Eitan ^c   Enden, Giora ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Mathematical model; Rectified diffusion; Skin permeation; Sonophoresis; Ultrasound

Indexed keywords

DIFFUSION; DRUG PRODUCTS; MATHEMATICAL MODELS; PATIENT TREATMENT; SKIN; ULTRASONIC EFFECTS;

RECTIFIED DIFFUSION; SKIN PERMEATION; SONOPHORESIS;

BUBBLE FORMATION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DIFFUSION; DRUG PENETRATION; GAS; LIPID BILAYER; MATHEMATICAL MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SKIN; SKIN PERMEABILITY; STRATUM CORNEUM; TRANSPORT KINETICS; ULTRASOUND;

ALGORITHMS; ANIMALS; COMPUTER SIMULATION; DIFFUSION; DRUG DELIVERY SYSTEMS; ELECTRIC CONDUCTIVITY; EPIDERMIS; GASES; MODELS, BIOLOGICAL; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SODIUM DODECYL SULFATE; SURFACE TENSION; SWINE; ULTRASONICS;

EID: 33846589381     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.10.027     Document Type: Article

References (38)

1. Kost J. Ultrasound-assisted insulin delivery and noninvasive glucose sensing. Diabetes Technol. Ther. 4 (2002) 489-497
2. Boucaud A., Garrigue M.A., Machet L., Vaillant L., and Patat F. Effect of sonication parameters on transdermal delivery of insulin to hairless rats. J. Control. Release 81 (2002) 113-119
3. Smith N.B., Lee S., and Shung K.K. Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays. Ultrasound Med. Biol. 29 (2003) 1205-1210
4. Monti D., Giannelli R., Chetoni P., and Burgalassi S. Comparison of the effect of ultrasound and of chemical enhancers on transdermal permeation of caffeine and morphine through hairless mouse skin in vitro. Int. J. Pharm. 229 (2001) 131-137
5. Boucaud A., Machet L., Arbeille B., Machet M.C., Souranc M., Mavon M., Patat F., and Vaillant L. In vitro study of low frequency ultrasound enhanced transdermal transport of fentanyl and caffeine across human and hairless rat skin. Int. J. Pharm. 228 (2001) 69-77
6. Mitragotri S., and Kost J. Low-frequency sonophoresis: a noninvasive method of drug delivery and diagnostics. Biotechnol. Prog. 16 (2000) 488-492
7. Merino G., Kalia Y.N., Delgado-Charro M.B., Potts R.O., and Guy R.H. Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis. J. Control. Release 88 (2003) 85-94
8. Tachibana K., and Tachibana S. Use of ultrasound to enhance the local anesthetic effect of topically applied aqueous lidocaine. Anesthesiology 78 (1993) 1091-1096
9. Tezel A., Sens A., and Mitragotri S. Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy. J. Pharm. Sci. 91 (2002) 444-453
10. Terahara T., Mitragotri S., and Langer R. Porous resins as a cavitation enhancer for low-frequency sonophoresis. J. Pharm. Sci. 91 (2002) 753-759
11. Tezel A., and Mitragotri S. Interactions of inertial cavitation bubbles with stratum corneum lipid bilayers during low-frequency sonophoresis. Biophys. J. 85 (2003) 3502-3512
12. Terahara T., Mitragotri S., Kost J., and Langer R. Dependence of low-frequency sonophoresis on ultrasound parameters; distance of the horn and intensity. Int. J. Pharm. 235 (2002) 35-42
13. Tang H., Mitragotri S., Blankschtein D., and Langer R. Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis. J. Pharm. Sci. 90 (2001) 545-568
14. Tezel A., Sens A., and Mitragotri S. A theoretical analysis of low-frequency sonophoresis: dependence of transdermal transport pathways on frequency and energy density. Pharm. Res. 19 (2002) 1841-1846
15. Tezel A., Sens A., and Mitragotri S. Incorporation of lipophilic pathways into the porous pathway model for describing skin permeabilization during low-frequency sonophoresis. J. Control. Release 83 (2002) 183-188
16. Tezel A., Sens A., and Mitragotri S. Description of transdermal transport of hydrophilic solutes during low-frequency sonophoresis based on a modified porous pathway model. J. Pharm. Sci. 92 (2003) 381-393
17. Tezel A., Sens A., Tuchscherer J., and Mitragotri S. Synergistic effect of low frequency ultrasound and surfactants on skin permeability. J. Pharm. Sci. 91 (2002) 91-100
18. Alvarez-Roman R., Merino G., Kalia Y.N., Naik A., and Guy R.H. Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways. J. Pharm. Sci. 92 (2003) 1138-1146
19. Kushner J., Blankschtein D., and Langer R. Experimental demonstration of the existence of highly permeable localized transport regions in low-frequency sonophoresis. J. Pharm. Sci. 93 (2004) 2733-2745
20. Paliwal S., Menon G.K., and Mitragotri S. Low-frequency sonophoresis: ultrastructural basis for stratum corneum permeability assessed using quantum dots. J. Invest. Dermatol. 126 (2006) 1095-1101
21. Crum L., and Hansen G. Growth of air bubbles in tissue by rectified diffusion. Phys. Med. Biol. 27 (1982) 413-417
22. Dick I., and Scott R. Pig ear skin as an in-vitro model for human skin permeability. J. Pharm. Pharmacol. 44 (1992) 640-645
23. Karande P., and Mitragotri S. High throughput screening of transdermal formulations. Pharm. Res. 19 (2002) 655-660
24. Berrutti L.E., Singer A.J., and McClain S.A. Histopathologic effects of cutaneous tape stripping in pigs. Acad. Emerg. Med. 7 (2001) 1349-1353
25. Mutoh M., Ueda H., Nakamura Y., Hirayama K., Atobe M., Kobayashi D., and Morimoto Y. Characterization of transdermal solute transport induced by low-frequency ultrasound in the hairless rat skin. J. Control. Release 92 (2003) 137-146
26. Cancel L., Tarbell J., and Ben-Jebria A. Fluorescein permeability and electrical resistance of human skin during low frequency ultrasound application. J. Pharm. Pharmacol. 56 (2004) 1109-1118
27. Chuang H.E., Taylor E., and Davison T. Clinical evaluation of a continuous minimally invasive glucose flux sensor placed over ultrasonically permeated skin. Diabetes Technol. Ther. 6 (2004) 21-30
28. Mitragotri S., Ray D., Farrell J., Tang H., Yu B., Kost J., Blankschtein D., and Langer R. Synergistic effect of low frequency ultrasound and sodium lauryl sulfate on transdermal transport. J. Pharm. Sci. 89 (2000) 892-900
29. Sekkat N., Kalia Y.N., and Guy R.H. Biophysical study of porcine ear skin in vitro and its comparison to human skin in vivo. J. Pharm. Sci. 91 (2002) 2376-2381
30. Crank J. The Mathematics of Diffusion. 2 ed. (1975), Clarendon Press, Oxford
31. Porter M.R. Handbook of Surfactants. 2nd ed. (1994), Blackie Academic & professional, Glasgow
32. Brenner M., Hilgenfeld S., and Lohse D. Single-bubble sonoluminescence. Rev. Mod. Phys. 74 (2002) 424-484
33. Mitragotri S., Blankschtein D., and Langer R. Transdermal drug delivery using low frequency sonophoresis. Pharm. Res. 13 (1996) 411-420
34. Lavon I., Grossman N., and Kost J. The nature of ultrasound-SLS synergism during enhanced transdermal transport. J. Control. Release 107 (2005) 484-494
35. Eller A. Bubble growth by diffusion in an 11-kHz sound field. J. Acoust. Soc. Am. 52 (1972) 1447-1449
36. Eller A. Damping constants of pulsating bubbles. J. Acoust. Soc. Am. 47 (1970) 1469-1470
37. Hatcher M., and Plachy W. Dioxygen diffusion in the stratum corneum: an EPR spin label study. Biochim. Biophys. Acta 1149 (1993) 73-78
38. Crum L. Measurements of the growth of air bubbles by rectified diffusion. J. Acoust. Soc. Am. 68 (1980) 203-211