Scaffold approach for solid-phase synthesis of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines

Journal of Combinatorial Chemistry

Volumn 9, Issue 1, 2007, Pages 9-11

  Zhang, Yandong ^a   Xu, Chuanlian ^b   Houghten, Richard A ^a,c   Yu, Yongping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG SCI TECH UNIVERSITY   (China)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; AMINE; IMIDAZOLE DERIVATIVE; QUINAZOLINE DERIVATIVE;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; METHODOLOGY; SYNTHESIS;

ALDEHYDES; AMINES; COMBINATORIAL CHEMISTRY TECHNIQUES; IMIDAZOLES; QUINAZOLINES;

EID: 33846567999     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc0601231     Document Type: Article

References (24)

1. (a) Combinatorial Chemistry: Synthesis, Analysis, Screening; Jung, G., Ed.; Wiley-VCH: Weinheim, 1999.
2. (b) Combinatorial Chemistry and Molecular DiVersity; In Drug Discovery; Gordon, E. M., Kerwin, J. F., Jr., Eds.; John Wiley & Sons Ltd.: New York, 1998.
3. (a) Dolle, R. E. J. Comb. Chem. 2005, 7, 739.
4. (b) Horton, D. A.; Bourne, G. T.; Smythe, M. L. Chem. Rev. 2003, 103, 893.
5. Nefzi, A.; Ostresh, J. M.; Yu, Y.; Houghten, R. A. J. Org. Chem. 2004, 69, 3603.
6. (b) Yu, Y.; Ostresh, J. M.; Houghten, R. A. J. Comb. Chem. 2004, 6, 83.
7. Wenzel, D. G. J. Am. Pharm. Assoc. 1955, 44, 550.
8. Hori, M.; Iemura, R.; Hara, H.; Ozaki, Akio.; Sukamoto, T.; Ohtaka, H. Chem. Pharm. Bull. 1990, 38, 681.
9. (a) Hayao, S.; Havera, H. J.; Stryeker, H. E. W. G.; Leipzig, T. G.; Kulp, R. A.; Hartzler, H. E. J. Med. Chem. 1965, 8, 807.
10. (b) Nishikawa, Y.; Shindo, T.; Ishii, K.; Nakamura, H.; Kona, T.; Uno, H. J. Med. Chem. 1989, 32, 583.
11. Havera, H. J.; Vidrio, H. J. J. Med. Chem. 1979, 22, 1548.
12. Chao, Q.; Deng, L.; Shih, H.; Leoni, L. M.; Genini, D.; Carson, D. A.; Cottam, H. B. J. Med. Chem. 1999, 42, 3860.
13. Kung, P. P.; Casper, M. D.; Cook, K. L.; Wilson-Lingardo, L.; Risen, L. M.; Vickers, T. A.; Ranken, R.; Blyn, L. B.; Wyatt, J. R.; Cook, P. D.; Ecker, D. J. J. Med. Chem. 1999, 42, 4705.
14. Glaser, T.; Traber, J. Agents Actions 1984, 15, 341.
15. Liverton, N. J.; Armstrong, D. J.; Claremon, D. A.; Remy, D. C.; Bardwin, J. J.; Lynch, R. J.; Zhang, G.; Gould, R. J. Bioorg. Med. Chem. Lett. 1998, 8, 483.
16. Rewcastle, G. W.; Palmer, B. D.; Bridges, A. J.; Hollis Showalter, H. D.; Sun, L.; Nelson, J.; McMichael, A.; Kraker, A. J.; Fry, D. W.; Denny, W. A. J. Med. Chem. 1996, 39, 918.
17. (a) Hollis Showalter, H. D.; Bridge, A. J.; Zhou, H.; Sercel, A. D.; McMichael, A.; Fry, D. W. J. Med. Chem. 1999, 42, 5464.
18. (b) Rae, J. M.; Lippman, M. E. Breast Cancer Res. Treat. 2004, 83, 99.
19. (c) Bridges, A. J.; Denny, W. A.; Fry, D.; Kraker, A.; Meyer, R. F.; Rewcastle, G. W.; Thompson, A. M.; Hollis Showalter, H. D. U.S. Patent 5,679,683, Dec 23, 1994.
20. (d) Schnur; Rodney; Caughren. WO Patent 9,749,688, Dec 31, 1997.
21. Wright, S. W; Hageman, D. L.; McClure, L. D.; Carlo, A. A.; Treadway, J. L.; Mathiowetz, A. M.; Withka, J. M.; Bauer, P. H. Bio. Med. Chem. Lett. 2001, 11, 17.
22. Toledo-Sherman, L.; Deretey, E.; Slon-Usakiewicz, J. J.; Ng, W.; Dai, J. R.; Foster, J. E.; Redden, P. R.; Uger, M. D.; Liao, L. C.; Pasternak, A.; Reid, N. J. Med. Chem. 2005, 48, 3221.
23. Slon-Usakiewicz, J. J.; Ng, W.; Foster, J. E.; Dai, J. R.; Deretey, E.; Toledo-Sherman, L.; Redden, P. R.; Pasternak, A.; Reid, N. J. Med. Chem. 2004, 47, 5094.
24. Lee, Y. B.; Ahn, C. H. U.S. Patent 2005,187,231, Feb 17, 2005.