Real-time PCR determination of human herpesvirus 6 antiviral drug susceptibility

Journal of Virological Methods

Volumn 140, Issue 1-2, 2007, Pages 25-31

  Isegawa, Yuji ^a   Takemoto, Masaya ^a   Yamanishi, Koichi ^a   Ohshima, Atsushi ^b   Sugimoto, Nakaba ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Antiviral drug; Ganciclovir; Ganciclovir resistance; HHV 6; Real time PCR

Indexed keywords

GANCICLOVIR;

ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 6; INTERMETHOD COMPARISON; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SUPERNATANT; TISSUE CULTURE; VIRUS CULTURE; VIRUS DETECTION; VIRUS ISOLATION;

ANTIVIRAL AGENTS; CELL LINE, TUMOR; DNA, VIRAL; GANCICLOVIR; HERPESVIRUS 6, HUMAN; HUMANS; POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

HUMAN HERPESVIRUS 6;

EID: 33846562364     PISSN: 01660934     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jviromet.2006.10.009     Document Type: Article

References (17)

1. Amo K., Tanaka-Taya K., Inagi R., Miyagawa H., Miyoshi H., Okusu I., Sashihara J., Hara J., Nakayama M., Yamanishi K., and Okada S. Human herpesvirus 6B infection of the large intestine of patients with diarrhea. Clin. Infect. Dis. 36 (2003) 120-123
2. de Bolle L., Micchel D., Mertens T., Manichanh C., Agut H., de Clercq E., and Naesens L. Role of the human herpesvirus 6 U69-encoded kinase in the phosphorylation of ganciclovir. Mol. Pharmacol. 62 (2002) 714-721
3. de Bolle L., Naesens L., and de Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin. Microbiol. Rev. 18 (2005) 217-245
4. Erice A. Resistance of human cytomegalovirus to antiviral drugs. Clin. Microbiol. Rev. 12 (1999) 286-297
5. Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T., Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., and Yamanishi K. Comparison of the complete DNA sequences between human herpesvirus-6 variants A and B. J. Virol. 73 (1999) 8053-8063
6. Kondo K., Kondo T., Okuno T., Takahashi M., and Yamanishi K. Latent human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 72 (1991) 1401-1408
7. Lusso P., Markhan P.D., Tschachler E., Di Marco Veronese F., Salahuddin S.Z., Ablashi D.V., Pahwa S., Grohn K., and Gallo R.C. In vitro cellular tropism of B-lymphotropic virus (human herpesvirus-6). J. Exp. Med. 167 (1988) 1659-1670
8. Manichanh C., Oliver-Aubron C., Lagarde J.-P., Aubin J.-T., Bossi P., Gantheret-Dejean A., Huraux J.-M., and Agut H. Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo. J. Gen. Virol. 82 (2001) 2767-27776
9. Okuno T., Asada H., Shiraki K., Takahashi M., and Yamanishi K. Analysis of a glycoprotein of human herpesvirus 6 (HHV-6) using monoclonal antibodies. Virology 176 (1990) 625-628
10. Puch S.S., Ocha C., Carballal G., Zala C., Cahn P., Brunet R., Salomón H., and Videla C. Cytomegalovirus UL97 mutations associated with ganciclovir resistance in immunocompromised patients from Argentina. J. Clin. Virol. 30 (2004) 271-275
11. Safronetz D., Petric M., Tellier R., Parvez B., and Tipples G.A. Mapping ganciclovir resistance in the human herpesvirus-6 U69 protein kinase. J. Med. Virol. 71 (2003) 434-439
12. Salahuddin S.Z., Ablashi D.V., Markham P., Josephs S.F., Sturzegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B., and Gallo R.C. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234 (1986) 596-601
13. Scott G.M., Issaacs M.A., Zeng F., Kesson A.M., and Rawlinson W.D. Cytomegalovirus antiviral resistance associated with treatment induced UL97 (protein kinase) and UL54 (DNA polymerase) mutations. J. Med. Virol. 74 (2004) 85-93
14. Stinski M.F. Human cytomegalovirus: glycoproteins associated with virions and dense bodies. J. Virol. 19 (1976) 594-609
15. Takahashi K., Sonoda S., Higashi K., Kondo T., Takahashi H., Takahashi M., and Yamanishi K. Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. J. Virol. 63 (1989) 3161-3163
16. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., and Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthema subitum. Lancet 1 (1988) 1065-1067
17. Zhou L., Harder T.C., Ullmann U., and Rautenberg P. Rapid detection by reverse hybridization of mutations in the UL97 gene of human cytomegalovirus conferring resistance to ganciclovir. J. Clin. Virol. 13 (1999) 53-59