Feasibility of D-glucuronate to enhance γ-hydroxybutyric acid metabolism during γ-hydroxybutyric acid toxicity: Pharmacokinetic and pharmacodynamic studies

Biopharmaceutics and Drug Disposition

Volumn 28, Issue 1, 2007, Pages 1-11

  Bhattacharya, Indranil ^a,b   Boje, Kathleen M K ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

D glucuronate; Nonlinear pharmacokinetics; Sodium oxybate; Toxicokinetics

Indexed keywords

4 HYDROXYBUTYRIC ACID; GLUCURONIC ACID; PLACEBO;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG INTOXICATION; DRUG METABOLISM; DRUG TRANSPORT; DRUG URINE LEVEL; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; PHARMACODYNAMICS; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD-BRAIN BARRIER; GLUCURONATES; HYDROXYBUTYRATES; HYPNOTICS AND SEDATIVES; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33846536368     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.525     Document Type: Article

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