IFNG and IFNGR1 gene polymorphisms and susceptibility to post-kala-azar dermal leishmaniasis in Sudan

Genes and Immunity

Volumn 8, Issue 1, 2007, Pages 75-78

  Salih, M A ^a   Ibrahim, M E ^a   Blackwell, J M ^b   Miller, E N ^b   Khalil, E A G ^a   ElHassan, A M ^a   Musa, A M ^a   Mohamed, H S ^a  

^a UNIVERSITY OF KHARTOUM   (Sudan)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR 1; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CHI SQUARE TEST; CONTROLLED STUDY; ETHNIC GROUP; GAMBIA; GENE DELETION; GENE INSERTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN TISSUE; INFLAMMATION; MAJOR CLINICAL STUDY; MALARIA; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; SKIN LEISHMANIASIS; STATISTICAL SIGNIFICANCE; SUDAN;

GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INTERFERON TYPE II; LEISHMANIASIS, CUTANEOUS; LEISHMANIASIS, VISCERAL; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RECEPTORS, INTERFERON; SUDAN;

NASO HEXACANTHUS;

EID: 33846534755     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364353     Document Type: Article

References (15)

1. Zijlstra EE, el-Hassan AM. Leishmaniasis in Sudan. Post kalaazar dermal leishmaniasis. Trans R Soc Trop Med Hyg 2001; 95 (Suppl 1): S59-S76.
2. Murray HW, Rubin BY, Rothermel CD. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine. J Clin Invest 1983; 72: 1506-1510.
3. Ismail A, El Hassan AM, Kemp K, Gasim S, Kadaru AE, Moller T et al. Immunopathology of post kala-azar dermal leishmaniasis (PKDL): T-cell phenotypes and cytokine profile. J Pathol 1999; 189: 615-622.
4. Gasim S, Elhassan AM, Kharazmi A, Khalil EA, Ismail A, Theander TG. The development of post-kala-azar dermal leishmaniasis (PKDL) is associated with acquisition of leishmania reactivity by peripheral blood mononuclear cells (PBMC). Clin Exp Immunol 2000; 119: 523-529.
5. Newport MJ, Huxley CM, Huston S, Hawrylowicz CM, Oostra BA, Williamson R et al. A mutation in the interferon-g-receptor gene and susceptibility to mycobacterial infection. N Engl J Med 1996; 26: 1941-1949.
6. Jouanguy E, Altare F, Lamhamedi S, Revy P, Emile JF, Newport M et al. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. N Engl J Med 1996; 335: 1956-1961.
7. Dorman SE, Holland SM. Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection. J Clin Invest 1998; 101: 2364-2369.
8. Altare F, Jouanguy E, Lamhamedi-Cherradi S, Fondaneche MC, Fizame C, Ribierre F et al. A causative relationship between mutant IFNgR1 alleles and impaired cellular response to IFNgamma in a compound heterozygous child. Am J Hum Genet 1998; 62: 723-726.
9. Mohamed HS, Ibrahim ME, Miller EN, Peacock CS, Khalil EA, Cordell HJ et al. Genetic susceptibility to visceral leishmaniasis in the Sudan: linkage and association with IL4 and IFNGR1. Genes Immun 2003; 4: 351-355.
10. Koch O, Awomoyi A, Usen S, Jallow M, Richardson A, Hull J et al. IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria. J Infect Dis 2002; 185: 1684-1687.
11. Awomoyi AA, Nejentsev S, Richardson A, Hull J, Koch O, Podinovskaia M et al. No association between interferongamma receptor-1 gene polymorphism and pulmonary tuberculosis in a Gambian population sample. Thorax 2004; 59: 291-294.
12. Bulat-Kardum L, Etokebe GE, Knezevic J, Balen S, Matakovic-Mileusnic N, Zaputovic L et al. Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis. Scand J Immunol 2006; 63: 142-150.
13. Pravica V, Perrey C, Stevens A, Lee JH, Hutchinson IV. A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 2000; 61: 863-866.
14. Bream JH, Ping A, Zhang X, Winkler C, Young HA. A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription. Genes Immun 2002; 3: 165-169.
15. Juliger S, Bongartz M, Luty AJ, Kremsner PG, Kun JF. Functional analysis of a promoter variant of the gene encoding the interferon-gamma receptor chain I. Immunogenetics 2003; 54: 675-680.