Assessment of homocysteine, neopterin and nitric oxide levels in Behcet's disease

Clinical Chemistry and Laboratory Medicine

Volumn 45, Issue 1, 2007, Pages 73-77

  Özkan, Yeşim ^a   Yardim Akaydin, Sevgi ^a   Sepici, Aylin ^b   Engin, Başak ^c   Sepici, Vesile ^a   Şimşek, Bolkan ^a  

^a GAZI UNIVERSITY   (Turkey)

^b UFUK UNIVERSITY   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Beh et's disease; Homocysteine; Immunity; Neopterin; Nitric oxide

Indexed keywords

HOMOCYSTEINE; NEOPTERIN; NITRIC OXIDE; NITRITE; REAGENT;

ADULT; ARTICLE; BEHCET DISEASE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME SYNTHESIS; FEMALE; FLUOROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; IMMUNE SYSTEM; MALE; PREVALENCE; PRIORITY JOURNAL; RECURRENT DISEASE; STOMATITIS;

ADULT; BEHCET SYNDROME; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; NEOPTERIN; NITRIC OXIDE; PREDICTIVE VALUE OF TESTS; RECURRENCE; STOMATITIS, APHTHOUS;

EID: 33846526096     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2007.018     Document Type: Article

References (45)

1. Evereklioglu C. Current concepts in the etiology and treatment of Behçet's Disease. Surv Ophthalmol 2005;50:297-350.
2. Jurge S, Kuffer R, Scully C, Porter SR. Recurrent aphthous stomatitis. Oral Dis 2006;12:1-21.
3. Finkelstein JD, Martin JJ. Homocysteine. Int J Biochem Cell Biol 2000;32:385-89.
4. McCully KS. Hyperhomocysteinemia and arteriosclerosis: historical perspective. Clin Chem Lab Med 2005;43:980-6.
5. Green R, Miller JW. Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population. Clin Chem Lab Med 2005;43:1048-51.
6. Van Guldener C, Stehouwer CD. Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction. Semin Thromb Hemost 2000;26:281-9.
7. Undas A, Brozek J, Szczeklik A. Homocysteine and thrombosis: from basic science to clinical evidence. Thromb Haemostasis 2005;94:907-15.
8. Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab 2005;6:27-36.
9. Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keany JF, et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 1997;272:17012-7.
10. Dudman NP, Temple SE, Guo XW, Fu W, Perry MA. Homocysteine enhances neutrophil-endothelial interactions in both cultured human cells and rats in vivo. Circ Res 1999;84:409-16.
11. Raziuddin S, al-Dalaan A, Bahabri S, Siraj AK, al-Sedairy S. Divergent cytokine production profile in Behcet's disease. Altered Th1/Th2 cell cytokine pattern. J Rheumatol 1998;25:329-33.
12. Moutabarrik A, Takahara S, Nakanishi I, Kokado Y, Takano Y, Kameoka H, et al. Interferon-g stimulates neopterin release from cultured kidney epithelial cells. Scand J Immunol 1994;39:27-30.
13. Hattori Y, Nakanishi N, Kasai K, Murakami Y, Shimoda S. Tetrahydrobiopterin and GTP cyclohydrolase I in a rat model of endotoxic shock: relation to nitric oxide synthesis. Exp Physiol 1996;81:665-71.
14. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990;335:1078-80.
15. Vester B, Rasmussen K. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 1991;29:549-54.
16. Krijt J, Vackova M, Kozich V. Measurement of homocysteine and other aminothiols in plasma: advantages of using tris(2-carboxyethyl)phosphine as reductant compared with tri-n-butylphosphine. Clin Chem 2001;47:1821-8.
17. Sawabe K, Wakasugi KO, Hasegawa H. Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process. J Pharmacol Sci 2004;96:124-33.
18. Hausen A, Fuchs D, Konig K, Wachter H. Determination of neopterin in human urine by reversed-phase high-performance liquid chromatography. J Chromatogr 1982;227:61-70.
19. Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 2001;5:62-71.
20. Koopman WJ. Arthritis and allied conditions. A textbook of rheumatology, 14th ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2001.
21. Romerio SC, Linder L, Nyfeler J, Wenk M, Litynsky P, Asmis R, et al. Acute hyperhomocysteinemia decreases NO bioavailability in healthy adults. Atherosclerosis 2004;176:337-44.
22. Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 2002;109:817-26.
23. Weiss N, Zhang Y-Y, Heydrick S, Bierl C, Loscalzo J. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proc Natl Acad Sci USA 2001;98:12503-8.
24. Orem A, Vanizor B, Cimsit G, Kiran E, Deger O, Malkoc M. Decreased nitric oxide production in patients with Behcet's Disease. Dermatol 1999;198:33-6.
25. Chambers JC, Haskard DO, Kooner JS. Vascular endothelial function and oxidative stress mechanisms in patients with Behcet's Syndrome. J Am Coll Cardiol 2001;37:517-20.
26. Budanlioglu S, Turkmen S, Ayabakan HB, Yenice N, Vardar M, Dogan S, et al. Nitric oxide, lipid peroxidation and antioxidant defence system in patients with active or inactive Behcet's disease. Br J Dermatol 2005;153:526-30.
27. Esmat S, El Sherif H, Anwar S, Fahmy I, Elmenyawi M, Shaker O. Lipoprotein (a) and nitrites in Behcet's disease: relationship with disease activity and vascular complications. Eur J Dermatol 2006;16:67-71.
28. Aksu K, Turgan N, Oksel F, Keser G, Özmen D, Kitapçioǧ lu G, et al. Hyperhomocysteinaemia in Behçet's disease. Rheumatology 2001;40:687-90.
29. Lee YJ, Kang SW, Yang JI, Choi YM, Sheen D, Lee EB, et al. Coagulation parameters and plasma total homocysteine levels in Behçet's disease. Thrombosis Res 2002;106:19-24.
30. Canataroglu A, Tanriverdi K, Inal T, Seydanoglu G, Arslan D, Ozbek S, et al. Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behcet's disease. Rheumatol Int 2003;23:236-40.
31. Ozdemir R, Barutcu I, Sezgin AT, Acikgoz N, Ermis N, Esen AM, et al. Vascular endothelial function and plasma homocysteine levels in Behcet's disease. Am J Cardiol 2004;94:522-5.
32. Ateş A, Aydintuǧ O, Ölmez Ü, Düzgün N, Duman M. Serum homocysteine levels is higher in Behçet's disease with vascular involvement. Rheumatol Int 2005;25:42-4.
33. Yesilova Z, Pay S, Oktenli C, Musabak U, Saglam K, Sanisoglu SY, et al. Hyperhomocysteinemia in patients with Behcet's disease: due to inflammation or therapy? Rheumatol Int 2005;25:423-8.
34. Yardim-Akaydin S, Sepici A, Ozkan Y, Şimşek B, Sepici V. Evaluation of allantoin levels as a new marker of oxidative stress in Behçet's Disease. Scand J Rheumatol 2005;34:1-4.
35. Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayek K. Cytokine profile in Behcet's disease patients. Relationship with disease activity. Scand J Rheumatol 2002;31:205-10.
36. Freysdottir J, Lau SH, Fortune F. γδ T cells in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS). Clin Exp Immunol 1999;118:451-7.
37. Koga T, Claycombe K, Meydani H. Homocysteine increases monocyte and T-cell adhesion to human aortic endothelial cells. Atherosclerosis 2002;161:365-74.
38. Dawson H, Collins G, Pyle R, Deep-Dixit V, Taub DD. The immunoregulatory effects of homocysteine and its intermediates on T-lymphocyte function. Mech Ageing Dev 2004;125:107-10.
39. Berdowska A, Zwirska-Korczala K. Neopterin measurement in clinical diagnosis. J Clin Pharm Ther 2001;26:319-29.
40. Coskun B, Saral Y, Godekmerdan A, Erden I, Coskun N. Activation markers in Behcet's disease. Skin Med 2005;4:282-6.
41. Kokcam I, Naziroglu M. Effects of vitamin E supplementation on blood antioxidants levels in patients with Behcet's disease. Clin Biochem 2002;35:633-9.
42. Keser G, Oksel F, Aksu K, Kabasakal Y, Gumusdis G, Doganavsargil E, et al. Serum neopterin levels in Behcet's syndrome. Clin Rheumatol 2000;19:328-9.
43. al-Dalaan A, al-Sedairy S, al-Balaa S, al-Janadi M, Elramahi K, Bahabri S, et al. Enhanced interleukin 8 secretion in circulation of patients with Behcet's disease. J Rheumatol 1995;22:904-7.
44. Altindaǧ ZZ, Werner-Felmayer G, Sahin G, Wachter H, Fuchs D. Colchicine derivatives inhibit neopterin production in human peripheral blood mononuclear cells (PBMC). Clin Exp Immunol 1997;107:574-7.
45. Vasquez-Vivar J, Kalyanaraman B, Martasek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. Free Radic Res 2003;37:121-7.