Antidepressants and suicidality. Risk-benefit analysis;Antidepressiva und suizidalität. Nutzen-risiko-abschätzung

Nervenarzt

Volumn 78, Issue 1, 2007, Pages 7-14

  Hegerl, U ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antidepressants; Depression; Selective serotonin reuptake inhibitors; Suicide

Indexed keywords

AMFEBUTAMONE; ANTIDEPRESSANT AGENT; CITALOPRAM; FLUOXETINE; FLUVOXAMINE; MIRTAZAPINE; NEFAZODONE; PAROXETINE; PLACEBO; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; TETRACYCLIC ANTIDEPRESSANT AGENT; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE;

CHILDHOOD; CLINICAL TRIAL; DEPRESSION; DRUG EFFICACY; DRUG OVERDOSE; DRUG SAFETY; GROUPS BY AGE; HELP SEEKING BEHAVIOR; HUMAN; PATIENT COMPLIANCE; RECURRENT DISEASE; REVIEW; RISK BENEFIT ANALYSIS; SUICIDAL IDEATION; SUICIDE;

ANTIDEPRESSIVE AGENTS; HUMANS; INCIDENCE; RISK ASSESSMENT; RISK FACTORS; SUICIDE;

EID: 33846519422     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00115-006-2109-8     Document Type: Review

References (35)

1. Ansorge MS, Zhou M, Lira A et al. (2004) Early-life blockade of the 5-HT transporter alters emotional behaviour in adult mice. Science 306:879-881
2. Barbui C, Campomori A, D'Avanzo B et al. (1999) Antidepressant drug use in Italy since the introduction of SSRIs: national trends, regional differences and impact on suicide rates. Soc Psychiatry Psychiatr Epidemiol 34:152-156
3. Bridge JA, Salary CB, Birmaher B et al. (2005) The risks and benefits of antidepressant treatment for youth depression. Ann Med 37:404-412
4. Emslie GJ, Heiligenstein JH, Hoog SL et al. (2004) Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled study. J Am Acad Child Adolesc Psychiatry 43:1397-1405
5. Fegert JM, Herpertz-Dahlmann B (2005) Serotoninwiederaufnahmehemmer im Kindes- und Jugendalter. Nervenarzt 76:1330-1339
6. Fergusson D, Doucette S, Glass K et al. (2005) Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ 330:396-402
7. Freemantle N, House A, Song F et al. (1994) Prescribing selective serotonin reuptake inhibitors as strategy for prevention of suicide. BMJ 309:249-253
8. Frey R, Schreinzer D, Stimpfl T et al. (2000) Suicide by antidepressant intoxication identified at autopsy in Vienna from 1991-1997: the favourable consequences oft he increasing use of SSRIs. Eur Neuropsychopharmacol 10:133-142
9. Frey R, Schreinzer D, Stimpfl T et al. (2002) Letale Intoxikationen mit Antidepressiva und Neuroleptika. Analyse im Zusammenhang mit den Verordnungen in Wien von 1991 bis 1997. Nervenarzt 73:629-636
10. Gibbons RD, Hur K, Bhaumik DK et al. (2005) The relationship between antidepressant medication use and rate of suicide. Arch Gen Psychiatry 62:165-172
11. Gunnell D, Ashby D (2004) Antidepressants and suicide: what is the balance of benefit and harm. BMJ 329:34-38
12. Gunnell D, Ho D, Murray V (2004) Medical management of deliberate drug overdose: a neglected area for suicide prevention? Emerg Med J 21:35-38
13. Gunnell D, Saperia J, Ashby D (2005) Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review. BMJ 330:385-389
14. Hall WD, Mant A, Mitchell PB et al. (2003) Association between antidepressant prescribing and suicide in Australia, 1991-2000: trend analysis. BMJ 326:1008-1011
15. Healy D (2003) Lines of evidence on the risks of suicide with selective serotonin reuptake inhibitors. Psychother Psychosom 72:71-79
16. Healy D, Langmaak C, Savage M (1999) Suicide in the course of the treatment of depression. J Psychopharmacol 13:94-99
17. Helgason T, Tómasson H, Zoega T (2004) Antidepressants and public health in Iceland. Time series analysis of national data. Br J Psychiatry 184:157-162
18. Isacsson G (2000) Suicide prevention - a medical breakthrough? Acta Psychiatr Scand 102:113-117
19. Isacsson G, Holmgren P, Ahlner J (2005) Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14.857 suicides. Acta Psychiatr Scand 111:286-290
20. Jick H, Kaye JA, Jick SS (2004) Antidepressants and the risk of suicidal behaviors. JAMA 292:338-343
21. Kelly CB, Ansari T, Rafferty T et al. (2003) Antidepressant prescribing and suicide rate in Northern Ireland. Eur Psychiatry 18:325-328
22. Khan A, Khan S, Kolts R et al. (2003) Suicide rates in clinical trials of SSRIs, other antidepressants, and placebo: analysis of FDA reports. Am J Psychiatry 160:790-792
23. Lohse M, Lorenzen A, Müller-Oerlinghausen B (2004) Psychopharmaka. In: Schwabe U, Paffrath D (Hrsg) Arzneiverordnungsreport 2004. Springer, Berlin Heidelberg New York, S 769-810
24. Lönnqvist J (2000) Psychiatric aspects of suicidal behaviour: depression. In: Hawton K, van Heeringen K (eds) The international handbook of suicide and attempted suicide. Wiley, Chichester, pp 107-120
25. March J, Silva S, Petrycki S et al. (2004) Fluoxetine, cognitive-behavioural therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial. JAMA 292:807-820
26. Martinez C, Rietbrock S, Wise L et al. (2005) Antidepressant treatment and the risk of fatal and nonfatal self harm in first episode depression: nested case-control study. BMJ 330:389-395
27. Möller HJ (1994) Einfluss von Antidepressiva auf die Suizidalität depressiver Patienten. Fortschr Neurol Psychiatr 62(Sonderheft 1):19-23
28. Müller-Oerlinghausen B, Berghöfer A (1999) Antidepressants and suicidal risk. J Clin Psychiatry 60(Suppl 2):94-99
29. Olfson M, Marcus SC, Weissman MM et al. (2003) National trends in the use of psychotropic medications by children. J Am Acad Child Adolesc Psychiatry 41:514-521
30. Simon GE, Savarino J, Operskalski B et al. (2006) Suicide risk during antidepressant treatment. Am J Psychiatry 163:41-47
31. US Food and Drug Administration (2004) FDA statement on recommendations of the Psychopharmacologic Drugs and Paediatric Advisory Committees. http://www.fda.gov/bbs/topics/news/2004/NEW01116.html.
32. Valuck RJ, Libby AM, Sills MR et al. (2004) Antidepressant treatment and risk of suicide attempt by adolescents with major depressive disorder: a propensity-adjusted retrospective cohort study. CNS Drugs 18:1119-1132
33. Vitiello B, Swedo S (2004) Antidepressant medications in children. N Engl J Med 350:1489-1491
34. Whittington CJ, Kendall T, Fonagy P et al. (2004) Selective serotonin reuptake inhibitors in childhood depression: a systematic review of published versus unpublished data. Lancet 363:1341-1345
35. Whyte IM, Dawson AH, Buckley NA (2003) Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. Q J Med 96:369-374