The possible role of endocrine disrupting chemicals in the aetiology of cryptorchidism and hypospadias: A population-based case-control study in rural Sicily

International Journal of Andrology

Volumn 30, Issue 1, 2007, Pages 3-13

  Carbone, P ^a   Giordano, F ^a   Nori, F ^a   Mantovani, A ^b   Taruscio, D ^b   Lauria, L ^b   Figa Talamanca I ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Agricultural work; Cryptorchidism; Endocrine disrupting chemicals; Hypospadias; Pesticides

Indexed keywords

ALCOHOL; ENDOCRINE DISRUPTOR; PESTICIDE;

AGRICULTURAL WORKER; ALCOHOL CONSUMPTION; ARTICLE; CHILD; CHILD HEALTH CARE; CONDOM; CONFIDENCE INTERVAL; CONTROLLED STUDY; CRYPTORCHISM; ENVIRONMENTAL EXPOSURE; FATHER; GYNECOLOGIC DISEASE; HUMAN; HYPOSPADIAS; ITALY; MAJOR CLINICAL STUDY; MALE; MATERNAL DISEASE; MOTHER; OCCUPATIONAL EXPOSURE; PATHOGENESIS; POPULATION BASED CASE CONTROL STUDY; POPULATION RISK; PRENATAL EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT; RURAL POPULATION;

ADULT; AGRICULTURE; ALCOHOL DRINKING; CASE-CONTROL STUDIES; CONTRACEPTION BEHAVIOR; CRYPTORCHIDISM; ENDOCRINE DISRUPTORS; FEMALE; HUMANS; HYPOSPADIAS; INFANT, NEWBORN; MALE; MATERNAL EXPOSURE; OCCUPATIONAL EXPOSURE; PATERNAL EXPOSURE; PREGNANCY; RISK FACTORS; RURAL POPULATION; SICILY; SMOKING;

EID: 33846516502     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2006.00703.x     Document Type: Article

References (30)

1. Arai, Y., Mori, T., Suzuki, Y. & Bern, H. A. (1983) Long term effects of perinatal exposures to sex-steroids and diethylstilbestrol on the reproductive system of male mammals. International Review of Cytology 84, 235-268.
2. Araneta, M. R., Schlangen, K. M., Edmonds, L. D., Destiche, D. A., Merz, R. D., Hobbs, C. A. et al. 2003. Prevalence of birth defects among infants of Gulf War veterans in Arkansas, Arizona, California, Georgia, Hawaii and Iowa, 1989-1993. Birth Defects Research. Part A, Clinical and Molecular Teratology 67, 246-260.
3. Aschim, E. L., Haugen, T. B., Tretli, S., Daltveit, A. K. & Grotmol, T. (2004). Risk factors for hypospadias in Norwegian boys - association with testicular dysgenesis syndrome? International Journal of Andrology 27, 213-221.
4. Baskin, L. S., Himes, K. & Colborn, T. (2001) Hypospadias and endocrine disruption: is there a connection? Environmental Health Perspectives 109, 1175-1183.
5. Bianca, S., Li Volti, G., Caruso-Nicoletti, M., Ettore, G., Barone, P., Lupo, L. et al. (2003) Elevated incidence of hypospadias in two Sicilian towns where exposure to industrial and agricultural pollutants is high. Reproductive Toxicology 17, 539-545
6. Carbone, P., Giordano, F., Nori, F., Figà-Talamanca, I., Lauria, L., Mantovani, A. et al. (2005) Criptorchidismo ed ipospadia nella provincia di Ragusa: uno studio epidemiologico. Not Ist Super Sanità 18, 3-4.
7. Carbone, P., Giordano, F., Nori, F., Figà-Talamanca, I., Mantovani, A. & Taruscio, D. (2006) Cryptorchidism and hypospadias in the Sicilian district of Ragusa and use of pesticides. Reproductive Toxicology In press.
8. Emanuele, N. & Emanuele, M. A. (1997) The endocrine system: alcohol alters critical hormonal balance. Alcohol Health and Research World 21, 53-64.
9. Fisher, J. S. (2004) Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 127, 305-315.
10. Garcia-Rodriguez, J., Garcia-Martin, M., Nogueras-Ocana, M., de Dios Luna-del-Castillo, J., Espigares Garcia, M., Olea, N. et al. (1996) Exposure to pesticides and cryptorchidism: geographical evidence of a possible association. Environmental Health Perspectives 104, 1090-1095.
11. Kallen, K. (2002) Role of maternal smoking and maternal reproductive history in the etiology of hypospadias in the offspring. Teratology 66, 185-191.
12. Kristensen, P., Irgens, L. M., Andersen, A., Bye, A. S. & Sundheim, L. (1997) Birth defects among offspring of Norwegian farmers, 1967-1991. Epidemiology 8, 537-544.
13. Maitoko, K. & Sasaki, H. (2004) Gonadotropin-releasing hormone agonist inhibits estrone sulfatase expression of cystic endometriosis in the ovary. Fertility and Sterility 82, 322-326.
14. Moller, H. & Skakkebaek, N. E. (1996) Risks of testicular cancer and cryptorchidism in relation to socio-economic status and related factors: case-control studies in Denmark. International Journal of Cancer 66, 287-293.
15. Norgil Damgaard, I., Main, K. M., Toppari, J. & Skakkebaek, N. E. (2002) Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction. Best Practice and Research. Clinical Endocrinology & Metabolism 16, 289-309.
16. Panagiotopoulou, K., Katsouyanni, K., Petridou, E., Garas, Y., Tzonou, A. & Trichopoulos, D. (1990) Maternal age, parity, and pregnancy estrogens. Cancer Causes and Control 1, 119-124.
17. Petrelli, G. & Figà-Talamanca, I. (2002) Ritardo al concepimento in lavoratori esposti a pesticidi (Delayed conception among workers exposed to pesticides). Giornale Italiano di Andrologia 9, 20-24.
18. Pierik, F. H., Burdof, A., Deddens, J. A., Juttman, R. E. & Weber, R. F. A. (2004) Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys. Environmental Health Perspectives 112, 1570-1576.
19. Savitz, D. A., Arbuckle, T., Kaczor, D. & Curtis, K. M. (1997) Male pesticide exposure and pregnancy outcome. American Journal of Epidemiology 146, 1025-1036.
20. Sharpe, R. M. (2003) The 'oestrogen hypothesis' - where do we stand now? International Journal of Andrology 26, 2-15.
21. Sharpe, R. M. & Skakkebaek, N. E. (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341, 1392-1395.
22. Shaw, G. M., Wasserman, C. R., O'Malley, C. D., Nelson, V. & Jackson, R. J. (1999) Maternal pesticide exposure from multiple sources and selected congenital anomalies. Epidemiology 10, 60-66.
23. Skakkebaek, N. E., Rajpert-De Meyts, E. & Main, K. M. (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Human Reproduction 16, 972-978.
24. Spitz, I. M., Croxatto, H. B. & Robbins, A. (1996) Antiprogestins: mechanism of action and contraceptive potential. Annual Review of Pharmacology and Toxicology 36, 47-81.
25. Stillman, R. J. (1982) In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance and male and female offspring. American Journal of Obstetrics and Gynecology 142, 905-921.
26. The Practice Committee of the American Society for Reproductive Medicine. 2004. Myomas and reproductive function. Fertility and Sterility 82 (Suppl. 1), 111-116.
27. Van Tongeren, M., Nieuwenhuijsen, M. J., Gardiner, K., Armstrong, B., Vrijheid, M., Dolk, H. et al. (2002) A job-exposure matrix for potential endocrine-disrupting chemicals developed for a study into the association between maternal occupational exposure and hypospadias. Annals of Occupational Hygiene 46, 465-477.
28. Vrijheid, M., Armstrong, B., Dolk, H., van Tongeren, M. & Botting, B. (2003) Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. Occupational and Environmental Medicine 60, 543-550.
29. Weidner, I. S., Moller, H., Jensen, T. K. & Skakkebaek, N. E. (1999) Risk factors for cryptorchidism and hypospadias. Journal of Urology 161, 1606-1609.
30. Younglai, E. V., Foster, W. G., Hughes, E. G., Trim, K. & Jarrell, J. F. (2002) Levels of environmental contaminants in human follicular fluid, serum, and seminal plasma of couples undergoing in vitro fertilization. Archives of Environmental Contamination and Toxicology 43, 121-126.